Results 31 to 40 of about 4,624 (210)

Vertigo due to cerebellar cavernous malformation: A case report

Radiology Case Reports, 2022
Central vertigo is a result of vestibular structure dysfunction in the central nervous system. Currently, misdiagnoses between peripheral and central lesions are frequent, and diagnostic testing costs are high.
Putri Maharani, MD, Hanik Badriyah Hidayati, MD; PhD, Shahdevi Nandar Kurniawan, MD; PhD   +2 more
doaj   +1 more source

Case Report: A novel heterozygous nonsense mutation in KRIT1 cause hereditary cerebral cavernous malformation

Frontiers in Oncology, 2023
Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system and mainly characterized by enlarged capillary cavities without intervening brain parenchyma. Genetic studies have identified three disease-causing genes (CCM1/
Zhenxing Liu, Kaikai Guo, Xuebin Hu, Xianqin Zhang   +3 more
doaj   +1 more source

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM [PDF]

The FEBS Journal, 2010
Cerebral cavernous malformations (CCM) are vascular lesions which can occur as a sporadic (80% of the cases) or familial autosomal dominant form (20%). Three CCM genes have been identified: CCM1/KRIT1, CCM2/MGC4607 and CCM3/PDCD10. Almost 80% of CCM patients affected with a genetic form of the disease harbor a heterozygous germline mutation in one of ...
Florence, Riant, Francoise, Bergametti, Xavier, Ayrignac, Gwenola, Boulday, Elisabeth, Tournier-Lasserve   +4 more
openaire   +4 more sources

Long-term outcomes of untreated cerebral cavernous malformations: a prospective, population-based cohort study. [PDF]

Lancet Reg Health Eur
Sandmann ACA, Vandertop WP, White PM, Verbaan D, Coutinho JM, Al-Shahi Salman R, Scottish Audit of Intracranial Vascular Malformations (SAIVMs) Steering Committee.   +6 more
europepmc   +3 more sources

A systematic review and meta-analysis of surgeries performed for cerebral cavernous malformation-related epilepsy in pediatric patients

Frontiers in Pediatrics, 2022
BackgroundThe clinical benefit of surgery for the treatment of cerebral cavernous malformation (CCM)-related epilepsy in pediatric patients is still controversial.
Xiangyu Gao, Kangyi Yue, Jidong Sun, Zheng Fang, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang   +10 more
doaj   +1 more source

Lifetime Risk of First Symptomatic ICH or Seizure in Familial Cerebral Cavernous Malformations: A Multicenter Patient Data Analysis. [PDF]

Neurology
Dammann P, Santos AN, Mavarani L, Guey S, Chabriat H, Herve D, Croft J, Renteria M, Jang D, Zhang J, Li D, Wu Z, Weng JC, Petracca A, Fusco C, D'Agruma L, Castori M, Rath M, Pilz RA, Felbor U, Steinberg GK, Gu J, Bervini D, Goldberg J, Raabe A, Cervio A, Villamil F, Rosales J, Rauschenbach L, Riess C, Oppong MD, Karadachi H, Ahmadipour Y, Wrede KH, Jabbarli R, Deuschl C, Li Y, Santos Piedade G, Köhrmann M, Frank B, Wälchli T, Schmidt B, Overstijns M, Beck J, Fung C, Al-Shahi Salman R, Flemming KD, Lanzino G, Zafar A, Weinsheimer S, Nelson J, Zabramski JM, Akers A, Morrison L, McCulloch CE, Kim H, Sure U, Brain Vascular Malformation Consortium Cerebral Cavernous Malformation Investigator Group.   +57 more
europepmc   +3 more sources

Is Location Everything? Regulation of the Endothelial CCM Signaling Complex

Frontiers in Cardiovascular Medicine, 2022
Recent advances have steadily increased the number of proteins and pathways known to be involved in the development of cerebral cavernous malformation (CCM).
Harsha Swamy, Angela J. Glading
doaj   +1 more source

A novel CCM2 variant in a family with non-progressive cognitive complaints and cerebral microbleeds [PDF]

, 2017
Lobar cerebral microbleeds are most often sporadic and associated with Alzheimer's disease. The aim of our study was to identify the underlying genetic defect in a family with cognitive complaints and multiple lobar microbleeds and a positive family ...
Barkhof, F. (Frederik), Cohn-Hokke, P.E. (P.), Flier, W.M. (Wiesje) van der, Holstege, H. (Henne), Meijers-Heijboer, E.J. (Hanne), Pijnenburg, Y.A.L. (Yolande), Scheltens, P. (Philip), Sistermans, E.A. (Erik), Swieten, J.C. (John) van, Weiss, M.M. (Marjan M.)   +9 more
core   +4 more sources

Bringing CCM into a dish: cell culture models for cerebral cavernous malformations

Medizinische Genetik, 2021
Abstract Cerebral cavernous malformations (CCMs) are vascular lesions that can cause severe neurological complications due to intracranial hemorrhage. Although the CCM disease genes, CCM1, CCM2, and CCM3, have been known for more than 15 years now, our understanding of CCM pathogenesis is still incomplete.
Skowronek, Dariush, Pilz, Robin A., Schwefel, Konrad, Much, Christiane D., Felbor, Ute, Rath, Matthias   +5 more
openaire   +2 more sources

Cerebral Cavernous Malformation: Immune and Inflammatory Perspectives

Frontiers in Immunology, 2022
Cerebral cavernous malformation (CCM) is a type of vascular anomaly that arises due to the dyshomeostasis of brain capillary networks. In the past two decades, many advances have been made in this research field.
Tianqi Tu, Tianqi Tu, Zhenghong Peng, Jian Ren, Jian Ren, Hongqi Zhang, Hongqi Zhang   +6 more
doaj   +1 more source