Results 51 to 60 of about 4,624 (210)

Role of pericytes in the development of cerebral cavernous malformations

iScience, 2022
Summary: Cerebral cavernous malformation (CCM) is caused by loss-of-function mutations in CCM1, CCM2, or CCM3 genes of endothelial cells. It is characterized by pericyte deficiency. However, the role of pericytes in CCMs is not yet clarified.
Zifeng Dai, Jingwei Li, Ying Li, Rui Wang, Huili Yan, Ziyu Xiong, Shiting Wu, Xi Yang, Dongbo Lu, Dongdong Zhang, Guofu Li, Yuwen Wang, Chunyang Men, Wenzhong Du, Xiangjian Zheng, Changbin Shi   +15 more
doaj   +1 more source

Varying clinical presentations of familial cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations (SCCMs)

Radiology Case Reports, 2012
We present a family afflicted by both extensive cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations (SCCMs). These may be inherited in an autosomal dominant pattern or occur sporadically. The presentation varies and may include a multitude of clinical symptoms separated in time and space.
Nicholas-Bublick, Selena, Koffman, Boyd M.   +1 more
openaire   +2 more sources

Familial cerebral cavernous malformations: Rio de Janeiro study and review of the recommendations for management Malformação cavernosa cerebral familiar: um estudo no Rio de Janeiro e revisão das recomendações para tratamento

Arquivos de Neuro-Psiquiatria, 2008
OBJECTIVE: Multiple cerebral cavernous malformation (CCM) is the hallmark of familial presentation of cavernous malformation in the brain. We describe an ongoing Familial Cerebral Cavernous Malformation Project in the Rio de Janeiro state showing genetic
Flávio Domingues, Emerson L. Gasparetto, Ricardo Andrade, Fabio Noro, Antônio Eiras, Judith Gault, Carlos Eduardo Silva Correia, Jorge Marcondes de Souza   +7 more
doaj   +1 more source

Maltese study of intracranial vascular malformations [PDF]

, 2018
Intracranial vascular malformations (IVMs) are responsible for 49% of spontaneous intraparenchymal brain haemorrhage in patients under 40 years of age.
Chircop, Charmaine, Dalli, Theresia, Mallia, Maria   +2 more
core   +1 more source

Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman

Case Reports in Radiology, 2021
Cerebral cavernous malformations (CCMs) are dilated blood vessels which can develop sporadically or in familial form and are the commonest malformations of blood vessels in the spinal cord and brain.
Klenam Dzefi-Tettey, Emmanuel Kobina Mesi Edzie, Philip Narteh Gorleku, Henry Kusodzi, Abdul Raman Asemah   +4 more
doaj   +1 more source

Inflammation and neutrophil extracellular traps in cerebral cavernous malformation [PDF]

, 2022
Correction: Volume79, Issue7 Article Number: 388 DOI: 10.1007/s00018-022-04418-8Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various neurological symptoms.
Conze, Lei L., Corada, Monica, Dejana, Elisabetta, Garlanda, Cecilia, Globisch, Maria Ascencion, Herre, Melanie, Huang, Hua, Jahromi, Behnam Rezai, Jauhiainen, Suvi, Laakso, Aki, Lampugnani, Maria Grazia, Magnusson, Peetra U., Malinverno, Matteo, Mantovani, Alberto, Niemelä, Mika, Olsson, Anna-Karin, Onyeogaziri, Favour Chinyere, Orsenigo, Fabrizio, Smith, Ross, Sundell, Veronica, Yau, Anthony C. Y.   +20 more
core   +1 more source

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

Trends in Molecular Medicine, 2013
Cerebral cavernous malformations (CCMs) are vascular lesions that can occur sporadically or as a consequence of inherited loss-of-function mutations, predominantly in the genes CCM1 (KRIT1), CCM2 (MGC4607, OSM, Malcavernin), or CCM3 (PDCD10, TFAR15). Inherited, familial CCM is characterized by the development of multiple lesions throughout a patient's ...
Andreas, Fischer, Juan, Zalvide, Eva, Faurobert, Corinne, Albiges-Rizo, Elisabeth, Tournier-Lasserve   +4 more
openaire   +4 more sources

Upregulation of transmembrane endothelial junction proteins in human cerebral cavernous malformations [PDF]

, 2010
OBJECT: Cerebral cavernous malformations (CCMs) are among the most prevalent cerebrovascular malformations, and endothelial cells seem to play a major role in the disease.
Chappell PM, Felbor U, Hilder TL, Revencu N, Robinson JR, Stahl S, Tsukita S, Vestweber D, Zhu Y   +8 more
core   +1 more source

Cerebral hemorrhage from an incidental cavernous malformation occurring at the progressive stage of immunoglobulin G4-related disease

Interdisciplinary Neurosurgery, 2018
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition that can affect almost any organ. In this case, a cerebral cavernous malformation (CCM) was incidentally detected by magnetic resonance imaging (MRI) performed to assess the ...
Junnichi Ayabe, M.D., Naoyuki Noda, M.D., Yuusuke Tsuchiya, M.D., Souta Toginn, M.D., Yoshihide Tanaka, M.D., Hiroyuki Mishima, M.D.   +5 more
doaj   +1 more source

An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain

Cells, 2021
Background: Brain arteriovenous malformations (BAVMs) and cerebral cavernous malformations (CCMs) are rare developmental anomalies of the intracranial vasculature, with an irregular tendency to rupture, and as of yet incompletely deciphered ...
Ioan Alexandru Florian, Andrei Buruiana, Teodora Larisa Timis, Sergiu Susman, Ioan Stefan Florian, Adrian Balasa, Ioana Berindan-Neagoe   +6 more
doaj   +1 more source