Results 111 to 120 of about 1,594,854 (292)

Measuring the thickness of the human cerebral cortex from magnetic resonance images.

Proceedings of the National Academy of Sciences of the United States of America, 2000
B. Fischl, A. M. Dale
semanticscholar   +1 more source

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

Nature Neuroscience, 2020
O. Bayraktar, Theresa Bartels, S. Holmqvist, Vitalii Kleshchevnikov, A. Martirosyan, D. Polioudakis, Lucile Ben Haim, Adam M. H. Young, M. Batiuk, Kirti Prakash, Alexander Brown, Kenny Roberts, Mercedes F. Paredes, R. Kawaguchi, J. Stockley, Khalida Sabeur, Sandra M. Chang, E. Huang, P. Hutchinson, E. Ullian, M. Hemberg, G. Coppola, M. Holt, D. Geschwind, D. Rowitch   +24 more
semanticscholar   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Distributed hierarchical processing in the primate cerebral cortex.

Cerebral Cortex, 1991
D. Felleman, D. C. Essen
semanticscholar   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Automatically parcellating the human cerebral cortex.

Cerebral Cortex, 2004
B. Fischl, A. V. D. van der Kouwe, C. Destrieux, E. Halgren, F. Ségonne, D. Salat, E. Busa, L. Seidman, Jill Goldstein, D. Kennedy, V. Caviness, N. Makris, B. Rosen, A. Dale   +13 more
semanticscholar   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

The organization of the human cerebral cortex estimated by intrinsic functional connectivity.

Journal of Neurophysiology, 2011
B. T. T. Yeo, Fenna M. Krienen, Jorge Sepulcre, Jorge Sepulcre, M. Sabuncu, M. Sabuncu, D. Lashkari, Marisa O. Hollinshead, Marisa O. Hollinshead, J. Roffman, J. Smoller, Lilla Zöllei, J. Polimeni, B. Fischl, B. Fischl, Hesheng Liu, Randy L. Buckner   +16 more
semanticscholar   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source