NeuroImage[18F]-Florbetazine ([18F]-92) is a selective PET tracer for β-amyloid (Aβ) depositions with a novel diaryl-azine scaffold to reduce lipophilicity and to achieve higher gray-to-white matter contrast.
Meiqi Wu +15 more
doaj +1 more source
Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. [PDF]
, 2014 Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective ...
Coffinier, Catherine +10 more
core
Electroencephalographic Correlates of the Speed (TIME) of the Central Processing of Information by the Higher Parts of Brain in Humans with the Different Individual-typological Features of the Higher Nervous Activity [PDF]
, 2016 The speed (time) of the central processing of information (SCPI) by the higher parts of brain and electric activity of the cerebral cortex were studied using the method of electroencephalography (EEG) in humans with the different individual-typological ...
Yukhimenko, L. (Lilia)
core +2 more sources
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Cortical Models for Movement Control [PDF]
, 2000 Defense Advanced Research Projects Agency and Office of Naval Research (N0014-95-l-0409)
Bullock, Daniel
core +1 more source
Role of brain perfusion SPECT with 99mTc HMPAO in the assessment of response to drug therapy in patients with autoimmune vasculitis: a prospective study [PDF]
, 2015 BACKGROUND: The diagnosis of vasculitis in the brain remains a quite difficult achievement. To the best of our knowledge, there is no imaging method reported in literature which is capable of reaching to a diagnosis of vasculitis with very high ...
Anna Margherita Maffione, 2 +11 more
core +1 more source
Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle +11 more
wiley +1 more source
Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex
Regenerative Therapy, 2016 The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired.
Itsuki Ajioka
doaj +1 more source
Dynamics of changes in the content of thyroid hormones and some neurotransmitters in brain of rats with experimental Alzheimer’s disease [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2017 Objective: Alzheimer's disease is one of the most common neurodegenerative diseases, and mechanisms of its development have been studied for many years.
Tatiana Gorbach +3 more
doaj +1 more source
Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage [PDF]
, 2004 BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates.
Freeman, Melissa J +6 more
core +3 more sources