Results 251 to 260 of about 161,579 (302)
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Transient cerebral ischemia: Pathophysiology
Progress in Cardiovascular Diseases, 1980Abstract The clinical features of TIAs in the anterior and posterior cerebral circulations are fairly uniform and usually easily recognized. The pathogenesis of TIAs is varied, complex, and incompletely understood. The importance of TIAs rests on the fact that they may serve as dramatic warnings of an impending stroke.
J W, Schmidley, J J, Caronna
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MicroRNAs in Cerebral Ischemia
Translational Stroke Research, 2010Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its ...
Lim, K.-Y. +7 more
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Pharmacotherapy of cerebral ischemia
Expert Opinion on Pharmacotherapy, 2009Ischemic stroke remains one of the leading causes of death and disability in the developed world. Despite many promising preclinical results, the only pharmacologic treatments proven effective in improving clinical outcome following ischemic stroke until now are administration of aspirin and acute thrombolysis using tissue-plasminogen activator.To ...
Andrew F, Ducruet +5 more
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Polyamines in cerebral ischemia
Neurochemical Pathology, 1988The present series of experiments was designed to study regional profiles of polyamines (putrescine, spermidine, and spermine) in reversible cerebral ischemia produced in rats and Mongolian gerbils. Polyamine profiles did not change during ischemia, but did following recirculation.
W, Paschen +3 more
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Microvascular Research, 1977
Abstract Total cerebral ischemia often injures or alters the microcirculation. This injury is highly variable within microregions, often resulting in different patterns of reperfusion within 100 μm. There is a growing consensus that the microcirculation injury is a consequence of ischemic brain injury rather than an essential pathogenetic step to it.
J H, Halsey +3 more
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Abstract Total cerebral ischemia often injures or alters the microcirculation. This injury is highly variable within microregions, often resulting in different patterns of reperfusion within 100 μm. There is a growing consensus that the microcirculation injury is a consequence of ischemic brain injury rather than an essential pathogenetic step to it.
J H, Halsey +3 more
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Cerebral Ischemia and Angiogenesis
Current Neurovascular Research, 2006Angiogenesis occurs in a wide range of conditions. As ischemic tissue usually depends on collateral blood flow from newly produced vessels, acceleration of angiogenesis should be of therapeutic value to ischemic disorders. Indeed, therapeutic angiogenesis reduced tissue injury in myocardial or limb ischemia.
Takeshi, Hayashi +6 more
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Cerebral ischemia and inflammation
Current Opinion in Neurology, 2001Cerebral ischemia is accompanied by a marked inflammatory reaction that is initiated by ischemia-induced expression of cytokines, adhesion molecules, and other inflammatory mediators, including prostanoids and nitric oxide. Preclinical studies suggest that interventions that are aimed at attenuating such inflammation reduce the progression of brain ...
C, Iadecola, M, Alexander
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Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion
Signal Transduction and Targeted Therapy, 2022Yang Shu, Yu-Jie Guo, Scott Ayton
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