Results 51 to 60 of about 263,206 (355)

Health‐Related Quality of Life in Rare Forms of Childhood‐Onset Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We assessed health‐related quality of life (HRQoL) in 80 children with rare hereditary spastic paraplegias using the Caregiver Priorities and Child Health Index of Life with Disabilities and clinician‐reported outcomes. HRQoL was consistently reduced, particularly in relation to motor, autonomic, and bulbar symptoms.
Henri J. D. Schmidt, Nicole Battaglia, Joshua Rong, Amy Tam, Siofra Carty, Vicente Quiroz, Kathryn Yang, Zainab Zaman, Luca Schierbaum, Katerina Bernardi, Julian E. Alecu, Darius Ebrahimi‐Fakhari   +11 more
wiley   +1 more source

Preliminary Effects of a Robot-Based Therapy Program with Atlas-2030 in Children with Cerebral Palsy Receiving Care at a Specialized Rehabilitation Center

Applied Sciences
Robot-based rehabilitation emerges as a promise to enhance mobility and improve the rehabilitation outcomes in children with cerebral palsy. The study aimed to evaluate the preliminary effects of a robot-based therapy program with Atlas-2030 on ...
Igor Salinas-Sánchez, María R. Huerta-Teutli, David Cordero-Cuevas, Guadalupe Maldonado-Guerrero, Raide A. González-Carbonell   +4 more
doaj   +1 more source

Manfaat Pendampingan Terhadap Peningkatan Pengetahuan Orang Tua Dalam Penanganan Anak Cerebral Palsy [PDF]

, 2013
Latar Belakang: Cerebral Palsy adalah yang ditandai dengan perkembangan motorik yang abnormal atau terlambat, seperti paraplegia spastik, hemiplegia atau tetraplegia, yang sering disertai dengan retardasi mental, kejang atau ataksia.
, Agus Widodo, S.Fis, M.Kes,, , Umi Budi Rahayu, SSt. Ft. SPd. M. Kes, Abdurrachman, Abdurrachman   +2 more
core  

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Bridging the gap: reflections on co-creation in knowledge translation

Research Involvement and Engagement
Background To address the research-practice gap, knowledge translation is a crucial step in which co-creation, including patient and public involvement (PPI), is key.
Marjolijn Ketelaar, Maureen Bult, Marike Willems-op Het Veld, Karen van Meeteren, Marij Roebroeck, Jeanine Voorman   +5 more
doaj   +1 more source

Brain Metabolism During A Lower Extremity Voluntary Movement Task in Children With Spastic Cerebral Palsy

Frontiers in Human Neuroscience, 2020
Reduced selective voluntary motor control (SVMC) is a primary impairment due to corticospinal tract (CST) injury in spastic cerebral palsy (CP). There are few studies of brain metabolism in CP and none have examined brain metabolism during a motor task ...
Eileen G. Fowler, Eileen G. Fowler, William L. Oppenheim, Marcia B. Greenberg, Loretta A. Staudt, Shantanu H. Joshi, Shantanu H. Joshi, Daniel H. S. Silverman, Daniel H. S. Silverman   +8 more
doaj   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Assessment of the structural brain network reveals altered connectivity in children with unilateral cerebral palsy due to periventricular white matter lesions

NeuroImage: Clinical, 2014
Background: Cerebral palsy (CP) is a term to describe the spectrum of disorders of impaired motor and sensory function caused by a brain lesion occurring early during development.
Kerstin Pannek, Roslyn N. Boyd, Simona Fiori, Andrea Guzzetta, Stephen E. Rose   +4 more
doaj   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source