Results 21 to 30 of about 435,514 (353)
Contributions of Aging to Cerebral Small Vessel Disease. [PDF]
Annual Review of Physiology, 2020 Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related ...
T. D. De Silva, F. Faraci
semanticscholar +3 more sources
Prevention and Management of Cerebral Small Vessel Disease [PDF]
Journal of Stroke, 2015 Lacunar infarcts/lacunes, white matter hyperintensities (WMH), and cerebral microbleeds (CMBs) are considered various manifestations of cerebral small vessel disease (SVD).
Vincent Mok, Jong S. Kim
doaj +3 more sources
Current pathophysiological concepts in Cerebral Small Vessel Disease [PDF]
Frontiers in Aging Neuroscience, 2014 The association between cerebral small vessel disease (SVD) – in the form of white matter lesions, infarctions, and hemorrhages – with vascular cognitive impairment (VCI), has mostly been deduced from observational studies.
Fred eRincon, Clinton eWright
doaj +4 more sources
Molecular Neurodegeneration, 2023 Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline.
Yasuteru Inoue +3 more
semanticscholar +1 more source
JAMA Neurology, 2023 Key Points Question Can modulators of cerebrovascular endothelial function, including isosorbide mononitrate (ISMN; a nitric oxide donor) and cilostazol (a phosphodiesterase-3 inhibitor), improve long-term outcomes after lacunar ischemic stroke? Findings
J. Wardlaw +15 more
semanticscholar +1 more source
HYPERTENSION, 2023 Hypertension-associated cerebral small vessel disease is a common finding in older people. Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical ...
A. Hainsworth +2 more
semanticscholar +1 more source
Multimodal neuroimaging of vestibular and postural networks: Investigating the pathophysiology of idiopathic dizziness in older adults [PDF]
, 2021 Successful ageing - the preservation of good performance into old age, is an aspiration for many and a challenge for society. Modifiable factors which account for ageing-related functional decline should thus be identified and reduced. As life expectancy
Ibitoye, Richard
core +1 more source
Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE® system
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1898-1909, December 2022., 2022 Abstract Objectives Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are well‐established in research settings, but their use in routine clinical practice remains a largely unexploited potential. Here, we examined the relationship between CSF biomarkers, measured by a fully automated immunoassay platform, and brain β‐amyloid (Aβ ...
Hisashi Nojima +9 more
wiley +1 more source
Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis
Age and Ageing, 2023 Background Gait impairment contributes to falls and frailty. Some studies suggest that cerebral small vessel disease (CSVD) is associated with gait impairment in the general population.
Breni Sharma +4 more
semanticscholar +1 more source
Cerebral small vessel disease: A glymphopathy? [PDF]
Current Opinion in Neurobiology, 2022 Small vessel disease (SVD) is a common instigator of dementia in the aging population. The hallmarks of SVD are enlargement of the perivascular spaces and white matter hyperintensities. The latter represents local fluid accumulation in white matter that either subsides or develops into lacunar infarcts.
Benveniste, Helene, Nedergaard, Maiken
openaire +3 more sources