Results 31 to 40 of about 265,507 (241)

Cerebral small-vessel disease is associated with the severity of diabetic retinopathy in type 1 diabetes

BMJ Open Diabetes Research & Care, 2021
Introduction Cerebral small-vessel disease is common in neurologically asymptomatic individuals with type 1 diabetes. The retinal vasculature is thought to mirror the brain’s vasculature, but data on this association are limited in type 1 diabetes.
Turgut Tatlisumak, Jukka Putaala, Daniel Gordin, Paula Summanen, Carol Forsblom, Per-Henrik Groop, Juha Martola, Marika I Eriksson, Sara Shams, Ron Liebkind, Lena M Thorn   +10 more
doaj   +1 more source

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease

JAMA Neurology, 2023
Key Points Question Can modulators of cerebrovascular endothelial function, including isosorbide mononitrate (ISMN; a nitric oxide donor) and cilostazol (a phosphodiesterase-3 inhibitor), improve long-term outcomes after lacunar ischemic stroke? Findings
J. Wardlaw, L. Woodhouse, I. Mhlanga, K. Oatey, A. Heye, J. Bamford, V. Cvoro, F. Doubal, T. England, Ahamad Hassan, A. Montgomery, J. O'Brien, C. Roffe, N. Sprigg, D. Werring, P. Bath   +15 more
semanticscholar   +1 more source

Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study

Stroke and vascular neurology, 2023
Objective This study aims to investigate the associations of glymphatic system with the presence, severity and neuroimaging phenotypes of cerebral small vessel disease (CSVD) in a community-based population.
Yunjiao Tian, Xueli Cai, Yijun Zhou, A. Jin, Suying Wang, Yingying Yang, Lerong Mei, J. Jing, Shan Li, Xia Meng, Tiemin Wei, Tao Liu, Yongjun Wang, Yuesong Pan, Yilong Wang   +14 more
semanticscholar   +1 more source

Large-vessel correlates of cerebral small-vessel disease [PDF]

Neurology, 2013
Our aim was to investigate the relationship of carotid structure and function with MRI markers of cerebral ischemic small-vessel disease.The study comprised 1,800 participants (aged 72.5 ± 4.1 years, 59.4% women) from the 3C-Dijon Study, a population-based, prospective cohort study, who had undergone quantitative brain MRI and carotid ultrasound.
Brisset, Marion, Boutouyrie, Pierre, Pico, Fernando, Zhu, Yicheng, Zureik, Mahmoud, Schilling, Sabrina, Dufouil, Carole, Mazoyer, Bernard, Laurent, Stéphane, Tzourio, Christophe, Debette, Stéphanie   +10 more
openaire   +3 more sources

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
core   +1 more source

Gait in Elderly With Cerebral Small Vessel Disease [PDF]

Stroke, 2010
Background and Purpose— Gait disorders are common in the elderly and are related to loss of functional independence and death. White matter lesions (WMLs) may be related, but only a minority of individuals with WMLs has gait disorders.
de Laat, K.F., van Norden, A.G.W., Gons, R.A.R., van Oudheusden, L.J.B., van Uden, I.W.M., Bloem, B.R., Zwiers, M.P., Zwiers, M.P., de Leeuw, F.E.   +8 more
openaire   +5 more sources

CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]

, 2002
Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core   +1 more source

Association of inflammatory markers with cerebral small vessel disease in community-based population

Journal of Neuroinflammation, 2022
This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD).
Li-Na Jiang, Xueli Cai, Dong-xiao Yao, J. Jing, Lerong Mei, Yingying Yang, Shan Li, A. Jin, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang   +13 more
semanticscholar   +1 more source

Genetics of common cerebral small vessel disease

Nature Reviews Neurology, 2022
Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI but does not manifest as clinical stroke, is highly prevalent in the general population, particularly with increasing age.
Constance Bordes, M. Sargurupremraj, A. Mishra, S. Debette   +3 more
semanticscholar   +3 more sources

NIHSS Scores in Ischemic Small Vessel Disease: A Study in CADASIL [PDF]

, 2012
Background: The National Institutes of Health Stroke Scale (NIHSS) is widely used to measure neurological deficits, evaluate the effectiveness of treatment and predict outcome in acute ischemic stroke.
Allili, Nassira, Chabriat, Hugues, Dichgans, Martin, Duering, Marco, Herve, Dominique, Jouvent, Eric, Yao, Ming   +6 more
core   +1 more source