Results 21 to 30 of about 127,750 (253)

Advanced MRI in cerebral small vessel disease [PDF]

International Journal of Stroke, 2022
Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. This review summarizes recent developments in advanced neuroimaging of cSVD with a focus on clinical and research applications. In the first section, we highlight how advanced structural imaging techniques, including diffusion magnetic resonance imaging (MRI), enable improved
Hilde van den Brink, Fergus N Doubal, Marco Duering   +2 more
openaire   +2 more sources

Advanced Neuroimaging of Cerebral Small Vessel Disease [PDF]

Current Treatment Options in Cardiovascular Medicine, 2017
Cerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in ...
Blair, Gordon W., Hernandez, Maria Valdez, Thrippleton, Michael J., Doubal, Fergus N., Wardlaw, Joanna M.   +4 more
openaire   +3 more sources

Cerebral small vessel disease: A glymphopathy?

Current Opinion in Neurobiology, 2022
Small vessel disease (SVD) is a common instigator of dementia in the aging population. The hallmarks of SVD are enlargement of the perivascular spaces and white matter hyperintensities. The latter represents local fluid accumulation in white matter that either subsides or develops into lacunar infarcts.
Benveniste, Helene, Nedergaard, Maiken
openaire   +3 more sources

Contributions of Aging to Cerebral Small Vessel Disease [PDF]

Annual Review of Physiology, 2020
Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related reductions in brain health.
T Michael, De Silva, Frank M, Faraci
openaire   +2 more sources

Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell‐type specificity, and genetic
Yijie He, Tao Zhang, Ping Zhu, Shan Gao, Shiyang Wu, Fengzhen Liu, Yan Chen, Yingshui Yao, Guiyou Liu   +8 more
doaj   +1 more source

Social Determinants of Health and Cerebral Small Vessel Disease: Is Epigenetics a Key Mediator?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Cerebral small vessel disease is highly prevalent, particularly in marginalized communities, and its incidence is expected to increase given the aging global population.
Livia Parodi, Ernst Mayerhofer, Kaavya Narasimhalu, Nirupama Yechoor, Mary E. Comeau, Jonathan Rosand, Carl D. Langefeld, Christopher D. Anderson   +7 more
doaj   +1 more source

Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia.
Yuhui Ma, Yan Han
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Targeting Cerebral Small Vessel Disease With MRI [PDF]

Stroke, 2017
Cerebral small vessel disease (SVD) is a severely debilitating disease affecting the smallest vessels in the brain. It is a major cause of cognitive decline, dementia, and functional disability in the elderly, and it is also responsible for ≈25% of all cerebral strokes.1,2 Still, treatment options are restricted to preventive risk management because ...
Zwanenburg, J.J.M., Osch, M.J.P. van
openaire   +3 more sources

Evolving Concept of Small Vessel Disease through Advanced Brain Imaging [PDF]

Journal of Stroke, 2015
Imaging plays a crucial role in studying and understanding cerebral small vessel disease. Several important findings have emerged from recent applications of advanced brain imaging methods.
Bo Norrving
doaj   +1 more source