Results 21 to 30 of about 132,897 (217)

Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell‐type specificity, and genetic
Yijie He, Tao Zhang, Ping Zhu, Shan Gao, Shiyang Wu, Fengzhen Liu, Yan Chen, Yingshui Yao, Guiyou Liu   +8 more
doaj   +1 more source

Proteostasis in Cerebral Small Vessel Disease

Frontiers in Neuroscience, 2019
Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination ...
Christof Haffner
doaj   +1 more source

Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia.
Yuhui Ma, Yan Han
doaj   +1 more source

Hypercholesterolemia induced cerebral small vessel disease.

PLoS ONE, 2017
BackgroundWhile hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, its significance for cerebral small vessel disease (CSVD) remains unclear.
Peter Kraft, Michael K Schuhmann, Cornelia Garz, Solveig Jandke, Daniela Urlaub, Stine Mencl, Alma Zernecke, Hans-Jochen Heinze, Roxana O Carare, Christoph Kleinschnitz, Stefanie Schreiber   +10 more
doaj   +1 more source

Social Determinants of Health and Cerebral Small Vessel Disease: Is Epigenetics a Key Mediator?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Cerebral small vessel disease is highly prevalent, particularly in marginalized communities, and its incidence is expected to increase given the aging global population.
Livia Parodi, Ernst Mayerhofer, Kaavya Narasimhalu, Nirupama Yechoor, Mary E. Comeau, Jonathan Rosand, Carl D. Langefeld, Christopher D. Anderson   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dawson's Fingers in Cerebral Small Vessel Disease

Frontiers in Neurology, 2020
To explore Dawson's fingers in cerebral small vessel disease (CSVD) and factors related to the development of Dawson's finger, we collected and analyzed clinical data of 65 patients with CSVD. We found a venous abnormality feature called Dawson's fingers
Aowei Lv, Zaiqiang Zhang, Ying Fu, Yaping Yan, Li Yang, Wenli Zhu   +5 more
doaj   +1 more source

Evolving Concept of Small Vessel Disease through Advanced Brain Imaging [PDF]

Journal of Stroke, 2015
Imaging plays a crucial role in studying and understanding cerebral small vessel disease. Several important findings have emerged from recent applications of advanced brain imaging methods.
Bo Norrving
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Cognitive impairment and amygdala subregion volumes in elderly with cerebral small vessel disease: A large prospective cohort study

Neurobiology of Disease
Although the amygdala is associated with cognitive impairment resulting from cerebral small vessel disease, the relationship between alterations in amygdala structure and cerebral small vessel disease (CSVD) remains controversial. Given that the amygdala
Zhenyu Cheng, Linfeng Yang, Jing Li, Yiwen Chen, Pengcheng Liang, Yuanyuan Wang, Na Wang, Xinyue Zhang, Yian Gao, Chaofan Sui, Meng Li, Changhu Liang, Lingfei Guo   +12 more
doaj   +1 more source