Results 31 to 40 of about 435,514 (353)

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia‐Ling Phuah, Jason Hassenstab, Carlos Cruchaga   +5 more
wiley   +1 more source

Research progress of impaired cerebral hemodynamics in cerebral small vessel disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral hemodynamic damage is an important mechanism in the pathogenesis of arteriolosclerotic cerebral small vessel disease (CSVD). The hemodynamic damage of cerebral small vessel disease includes the changes of blood pressure variability (BPV ...
LIU Na, XUE Yang, TANG Jie, ZHANG Miao⁃yi, REN Xue , FU Jian⁃hui   +5 more
doaj   +1 more source

Cerebral small vessel disease: Recent advances and future directions

International Journal of Stroke, 2022
Cerebral small vessel disease (SVD) causes lacunar stroke and intracerebral hemorrhage, and is the most common pathology underlying vascular cognitive impairment.
H. Markus, Frank Erik de Leeuw
semanticscholar   +1 more source

Cerebral Small Vessel Disease and Cerebral Amyloid Angiopathy [PDF]

, 2022
Sporadic cerebral small vessel disease (SVD) is considered to be among the most commonly known neuropathological processes in the brain, hosting a crucial role in stroke, cognitive impairment, and functional loss in elderly subjects.
Valenti, Raffaella
core   +1 more source

Association of inflammatory markers with cerebral small vessel disease in community-based population

Journal of Neuroinflammation, 2022
This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD).
Li-Na Jiang, Xueli Cai, Dong-xiao Yao, J. Jing, Lerong Mei, Yingying Yang, Shan Li, A. Jin, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang   +13 more
semanticscholar   +1 more source

Microglial activation and blood–brain barrier permeability in cerebral small vessel disease

Brain : a journal of neurology, 2021
See Edison (doi:10.1093/brain/awab149) for a scientific commentary on this article. Using advanced brain imaging techniques, Walsh et al. provide evidence of both neuroinflammation and increased blood-brain barrier permeability in patients with cerebral ...
J. Walsh, D. Tozer, H. Sari, Young T. Hong, A. Drazyk, Guy B. Williams, N. Shah, J. O'Brien, F. Aigbirhio, G. Rosenberg, T. Fryer, H. Markus   +11 more
semanticscholar   +1 more source

Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment [PDF]

, 2023
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the development of white matter lesions.
Ahmed, Zubair, Backes, Walter H., Blankesteijn, W. Matthijs, Caiment, Florian, Foulquier, Sébastien, Fulton, Daniel, Jansen, Jacobus F. A., Leenders, Peter, Majcher, Daria, Manukjan, Narek, Smeets, Hubert J., Staals, Julie, Suidgeest, Ernst, van der Weerd, Louise, van Herwijnen, Marcel, van Oostenbrugge, Robert J., Vanmierlo, Tim   +16 more
core   +2 more sources

Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets

Frontiers in Aging Neuroscience, 2022
Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular diseases primarily affecting small arteries, capillaries, arterioles and venules.
Yue Gao, Di Li, Jianwen Lin, Aline M. Thomas, Jianyu Miao, Dong Chen, Shen Li, Chengyan Chu   +7 more
semanticscholar   +1 more source

Association of Data-Driven White Matter Hyperintensity Spatial Signatures With Distinct Cerebral Small Vessel Disease Etiologies

Neurology, 2022
Background and Objectives Topographical distribution of white matter hyperintensities (WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased pattern discovery approach to identify distinct WMH spatial patterns and investigate
C. Phuah, Yasheng Chen, Jeremy F. Strain, Nirupama Yechoor, Osvaldo Laurido-Soto, B. Ances, Jin-Moo Lee   +6 more
semanticscholar   +1 more source

DS6, Deformation-aware Semi-supervised Learning: Application to Small Vessel Segmentation with Noisy Training Data [PDF]

Journal of Imaging. 2022; 8(10):259, 2020
Blood vessels of the brain provide the human brain with the required nutrients and oxygen. As a vulnerable part of the cerebral blood supply, pathology of small vessels can cause serious problems such as Cerebral Small Vessel Diseases (CSVD). It has also been shown that CSVD is related to neurodegeneration, such as Alzheimer's disease.
arxiv   +1 more source