Results 31 to 40 of about 211,077 (381)

Cerebral small vessel disease: Recent advances and future directions

International Journal of Stroke, 2022
Cerebral small vessel disease (SVD) causes lacunar stroke and intracerebral hemorrhage, and is the most common pathology underlying vascular cognitive impairment.
H. Markus, Frank Erik de Leeuw
semanticscholar   +1 more source

Microglial activation and blood–brain barrier permeability in cerebral small vessel disease

Brain : a journal of neurology, 2021
See Edison (doi:10.1093/brain/awab149) for a scientific commentary on this article. Using advanced brain imaging techniques, Walsh et al. provide evidence of both neuroinflammation and increased blood-brain barrier permeability in patients with cerebral ...
J. Walsh, D. Tozer, H. Sari, Young T. Hong, A. Drazyk, Guy B. Williams, N. Shah, J. O'Brien, F. Aigbirhio, G. Rosenberg, T. Fryer, H. Markus   +11 more
semanticscholar   +1 more source

Association of inflammatory markers with cerebral small vessel disease in community-based population

Journal of Neuroinflammation, 2022
This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD).
Li-Na Jiang, Xueli Cai, Dong-xiao Yao, J. Jing, Lerong Mei, Yingying Yang, Shan Li, A. Jin, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang   +13 more
semanticscholar   +1 more source

Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets

Frontiers in Aging Neuroscience, 2022
Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular diseases primarily affecting small arteries, capillaries, arterioles and venules.
Yue Gao, Di Li, Jianwen Lin, Aline M. Thomas, Jianyu Miao, Dong Chen, Shen Li, Chengyan Chu   +7 more
semanticscholar   +1 more source

Association of Data-Driven White Matter Hyperintensity Spatial Signatures With Distinct Cerebral Small Vessel Disease Etiologies

Neurology, 2022
Background and Objectives Topographical distribution of white matter hyperintensities (WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased pattern discovery approach to identify distinct WMH spatial patterns and investigate
C. Phuah, Yasheng Chen, Jeremy F. Strain, Nirupama Yechoor, Osvaldo Laurido-Soto, B. Ances, Jin-Moo Lee   +6 more
semanticscholar   +1 more source

Cerebral Small Vessel Disease and Cerebral Amyloid Angiopathy [PDF]

, 2022
Sporadic cerebral small vessel disease (SVD) is considered to be among the most commonly known neuropathological processes in the brain, hosting a crucial role in stroke, cognitive impairment, and functional loss in elderly subjects.
Valenti, Raffaella
core   +1 more source

The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease

Frontiers in Aging Neuroscience, 2022
The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. The glymphatic system dysfunction, which has been demonstrated to influence cognitive impairment, can be evaluated by diffusion tensor image ...
Jie Tang, Miaoyi Zhang, Na Liu, Yang Xue, Xue Ren, Qi Huang, Langfeng Shi, Jianhui Fu   +7 more
semanticscholar   +1 more source

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

JAMA Neurology, 2022
Importance Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology.
H. Markus, W. M. van der Flier, E. Smith, P. Bath, G. Biessels, E. Briceño, Amy Brodtman, H. Chabriat, Christopher P L H Chen, F. de Leeuw, M. Egle, A. Ganesh, Marios K. Georgakis, R. Gottesman, S. Kwon, L. Launer, Vincent C. T. Mok, J. O'Brien, Lois Ottenhoff, S. Pendlebury, E. Richard, P. Sachdev, R. Schmidt, Melanie Springer, Stefan Tiedt, J. Wardlaw, A. Verdelho, A. Webb, D. Werring, M. Duering, D. Levine, M. Dichgans   +31 more
semanticscholar   +1 more source

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
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HTRA1-related autosomal dominant cerebral small vessel disease

Chinese Medical Journal, 2021
. Background. Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL ...
Jing-Yi Liu, Yi-Cheng Zhu, Li-Xin Zhou, Yan-Ping Wei, Chen-Hui Mao, Li-Ying Cui, Bin Peng, Ming Yao, Xin Chen   +8 more
doaj   +1 more source