Results 81 to 90 of about 198,856 (347)

Cerebral Hypoperfusion and the Energy Deficit in Alzheimer's Disease [PDF]

, 2016
There is a perfusion deficit in Alzheimer's disease (AD), commencing in the precuneus and spreading to other parts of the cerebral cortex. The deficit anticipates the development of dementia, contributes to brain damage, and is caused by both functional ...
An, An, Arvanitakis, Ashby, Asllani, Attems, Baloyannis, Barker, Barker, Bell, Benzinger, Binnewijzend, Blin, Borroni, Bouras, Brown, Buee, Cadavid, Ceravolo, Challa, Chalmers, Chao, Charidimou, Chen, Cipolla, Claassen, Cohen, Cohen, Crawford, Dai, Davies, Dohi, Dore-Duffy, Drake, Dumas, Eckman, Eckman, Eckman, Elesber, Elhusseiny, Ellis, Esiri, Esiri, Fergus, Fischer, Gentile, Greer, Hamel, Hamilton, Haque, Hunter, Jeynes, Kakinuma, Kalaria, Kar, Kehoe, Kehoe, Kehoe, Kehoe, Kitaguchi, Kivipelto, Krick, Krimer, Lamoke, Langbaum, Launer, Lee, Liu, Love, Love, Love, Love, Masuda, Miners, Miners, Miners, Miners, Miners, Mondello, Montagne, Morris, Morris, Nagata, Nagata, Nation, Niwa, Niwa, Niwa, Niwa, Niwa, Noll, Nor, Okazaki, Palmer, Palmer, Palmer, Palmer, Paris, Paris, Paris, Paris, Park, Park, Patel, Paulson, Peca, Peppiatt, Power, Premkumar, Price, Pákáski, Raichle, Raja, Rodrigue, Rossi, Rubin, Rubin, Sagare, Schmechel, Scott, Sengillo, Shimizu, Shin, Smith, Stow, Suhara, Tan, Tarkowski, Tarumi, Tayler, Thal, Thomas, Thomas, Toews, Tohgi, Tomonaga, Tong, Townsend, Tschope, Vaucher, Vinters, Waite, Winkler, Yamada, Yan, Yang, Zetterberg, Zhang, Zhu   +148 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Prevention and Management of Cerebral Small Vessel Disease [PDF]

Journal of Stroke, 2015
Lacunar infarcts/lacunes, white matter hyperintensities (WMH), and cerebral microbleeds (CMBs) are considered various manifestations of cerebral small vessel disease (SVD).
Vincent Mok, Jong S. Kim
doaj   +1 more source

What is cerebral small vessel disease?

Rinsho Shinkeigaku, 2011
An accumulating amount of evidence suggests that the white matter hyperintensities on T2 weighted brain magnetic resonance imaging predict an increased risk of dementia and gait disturbance. This state has been proposed as cerebral small vessel disease, including leukoaraiosis, Binswanger's disease, lacunar stroke and cerebral microbleeds. However, the
openaire   +3 more sources

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial

Trials, 2017
Background Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease.
Mathilde M. H. Pauls, Natasha Clarke, Sarah Trippier, Shai Betteridge, Franklyn A. Howe, Usman Khan, Christina Kruuse, Jeremy B. Madigan, Barry Moynihan, Anthony C. Pereira, Debbie Rolfe, Egill Rostrup, Caroline E. Haig, Thomas R. Barrick, Jeremy D. Isaacs, Atticus H. Hainsworth   +15 more
doaj   +1 more source

Alzheimer and vascular brain diseases: Focal and diffuse subforms. [PDF]

, 2015
Alois Alzheimer is best known for his description of the pre-senile neurodegenerative disease named after him. However, his previous interest in vascular brain diseases, underlying cognitive and behavioral changes, was very strong. Besides describing the
Engelhardt, Eliasz, Grinberg, Lea T
core   +2 more sources

Isolated Subtle Neurological Abnormalities in Mild Cognitive Impairment Types [PDF]

, 2020
Background: Isolated, subtle neurological abnormalities (ISNA) are commonly seen in aging and have been related to cerebral small vessel disease (SVD) and subcortical atrophy in neurologically and cognitively healthy aging subjects.
Azzarello, Delia, Camarda, Cecilia, Camarda, Rosolino, Cilluffo, Giovanna, Grassedonio, Emanuele, Pipia, Carmela, Sottile, Gianluca, Torelli, Paola   +7 more
core   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

Neuroimaging of Cerebral Small Vessel Disease

Brain Pathology, 2014
Neuroimaging of cerebral small vessel vascular disease is often nonspecific and the diagnosis is challenging; clinical and family history is pivotal in interpreting neuroimaging findings. Hereditary small vessel diseases have recently gained significant interest, and MRI is a sensitive tool to detect white matter abnormality.
openaire   +3 more sources