Results 81 to 90 of about 435,514 (353)

Impaired Retinal Vasoreactivity: An Early Marker of Stroke Risk in Diabetes [PDF]

, 2016
Diabetes is a common cause of small vessel disease leading to stroke and vascular dementia. While the function and structure of large cerebral vessels can be easily studied, the brain’s microvasculature remains difficult to assess.
Bettermann, Kerstin, Gardner, Thomas W., Lott, Mary E., Quillen, David, Shivkumar, Vikram, Slocomb, Julia   +5 more
core   +1 more source

Retinal vascular changes in persons with cerebral small vessel disease

Journal of Medical and Scientific Research
The retinal and cerebral microvasculature share many morphological and physiological properties, Hence, it is thought that studying these retinal vessels will provide a direct measure to evaluate the vascular and neuronal status of the brain.
Prasanth Varghese C, Krishna Teja Kandela, Fiju Chacko, Monsy Thomas Mathai   +3 more
doaj   +1 more source

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Brain : a journal of neurology, 2022
Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited.
A. Mishra, C. Duplàa, D. Vojinovic, Hideaki Suzuki, M. Sargurupremraj, Nuno R Zilhao, Shuo Li, Traci M. Bartz, X. Jian, Wei Zhao, E. Hofer, K. Wittfeld, S. Harris, Sandra van der Auwera-Palitschka, M. Luciano, J. Bis, H. Adams, C. Satizabal, R. Gottesman, P. Gampawar, R. Bülow, S. Weiss, Miao Yu, M. Bastin, O. Lopez, M. Vernooij, A. Beiser, U. Völker, T. Kacprowski, A. Soumaré, Jennifer A. Smith, D. Knopman, Z. Morris, Yicheng Zhu, J. Rotter, C. Dufouil, M. V. Valdés Hernández, S. Muñoz Maniega, M. Lathrop, E. Boerwinkle, R. Schmidt, M. Ihara, B. Mazoyer, Qiong Yang, A. Joutel, E. Tournier-Lasserve, L. Launer, I. Deary, T. Mosley, P. Amouyel, C. DeCarli, B. Psaty, C. Tzourio, S. Kardia, H. Grabe, A. Teumer, C. V. van Duijn, H. Schmidt, J. Wardlaw, M. A. Ikram, M. Fornage, V. Gudnason, S. Seshadri, P. Matthews, W. Longstreth, T. Couffinhal, S. Debette   +66 more
semanticscholar   +1 more source

Age-Related Changes in Processing Speed: Unique Contributions of Cerebellar and Prefrontal Cortex [PDF]

, 2010
Age-related declines in processing speed are hypothesized to underlie the widespread changes in cognition experienced by older adults. We used a structural covariance approach to identify putative neural networks that underlie age-related structural ...
Calhoun, Vince D., Eckert, Mark A., Harris, Kelly C., Keren, Noam I., Roberts, Donna R.   +4 more
core   +3 more sources

Bi-allelic NIT1 variants cause a brain small vessel disease characterized by movement disorders, massively dilated perivascular spaces, and intracerebral hemorrhage [PDF]

Purpose: To describe a recessively inherited cerebral small vessel disease, caused by loss-of-function variants in Nitrilase1 (NIT1). Methods:We performed exome sequencing, brain magnetic resonance imaging, neuropathology, electron microscopy, western ...
Baas, Frank, Baelde, Hans J., Berendse, Henk W., Cerfontaine, Minne N., de Bot, Susanne T., Dijkstra, Kyra L., Gravesteijn, Gido, Jost, Carolina R., Koning, Roman I., Kruit, Mark, Lesnik Oberstein, Saskia A.J., Mei, Leon H., Mulder, Aat A., Nibbeling, Esther A.R., Ruijter, George J.G., Rutten, Julie W., van Duinen, Sjoerd G., van Nieuwenhuizen, Koen M., Vreijling, Jeroen   +18 more
core   +4 more sources

Cardiovascular co-morbidities, inflammation and cerebral small vessel disease.

Cardiovascular Research, 2021
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and affects all levels of the brain's vasculature. Features include diverse structural and functional changes affecting small arteries and capillaries that ...
Lowri E. Evans, Jade L Taylor, Craig J. Smith, Harry A T Pritchard, A. Greenstein, S. Allan   +5 more
semanticscholar   +1 more source

Cerebral small vessel disease and Alzheimer’s disease

Clinical Interventions in Aging, 2015
Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger's disease, and cerebral microbleeds.
Liang-Jun Yan, Zhengang Tang, Zhiyou Cai, Hanjun Tu, Wenbo He, Chuanling Wang, Ming Xiao   +6 more
openaire   +5 more sources

Genetic considerations in cerebral small vessel diseases

Frontiers in Neurology, 2023
Cerebral small vessel disease (CSVD) encompasses a broad clinical spectrum united by pathology of the small vessels of the brain. CSVD is commonly identified using brain magnetic resonance imaging with well characterized markers including covert infarcts, white matter hyperintensities, enlarged perivascular spaces, and cerebral microbleeds.
Riwaj Bhagat, Sandro Marini, José R. Romero, José R. Romero   +3 more
openaire   +3 more sources

Relation between physical activity and cerebral small vessel disease: A nine-year prospective cohort study. [PDF]

, 2021
BACKGROUND AND AIMS: Given the unexplored potential of physical activity to reduce the progression of cerebral small vessel disease (cSVD, the purpose of this study was to prospectively (across nine-year follow-up) examine the relation between (baseline)
de Leeuw, F-E, Landman, TR, Thijssen, DHJ, Tuladhar, AM   +3 more
core   +1 more source

Cognitive impairment in cerebral small vessel disease induced by hypertension

Neural Regeneration Research
Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease, the most common cerebrovascular disease.
Weipeng Wei, Denglei Ma, Lin Li, Lan Zhang   +3 more
doaj   +1 more source