Results 81 to 90 of about 211,077 (381)

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Nature Network Boston, 2021
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia.
Marie-Gabrielle Duperron, M. Knol, Quentin Le Grand, T. Evans, A. Mishra, A. Tsuchida, Gennady V. Roshchupkin, T. Konuma, D. Trégouët, J. Romero, Stefan Frenzel, M. Luciano, E. Hofer, M. Bourgey, Nicole D Dueker, P. Delgado, S. Hilal, Rick M. Tankard, Florian Dubost, Jean Shin, Y. Saba, N. Armstrong, Constance Bordes, M. Bastin, A. Beiser, H. Brodaty, R. Bülow, C. Carrera, Christopher P L H Chen, Ching-Yu Cheng, I. Deary, P. Gampawar, J. Himali, Jiyang Jiang, T. Kawaguchi, Shuo Li, Mélissa Macalli, P. Marquis, Z. Morris, S. Muñoz Maniega, Susumu Miyamoto, M. Okawa, Matt Paradise, Pedram Parva, T. Rundek, M. Sargurupremraj, Sabrina Schilling, K. Setoh, Omar Soukarieh, Y. Tabara, A. Teumer, A. Thalamuthu, J. Trollor, M. V. Valdés Hernández, M. Vernooij, U. Völker, K. Wittfeld, T. Wong, M. Wright, Junyi Zhang, Wanting Zhao, Yicheng Zhu, H. Schmidt, P. Sachdev, W. Wen, Kazumichi Yoshida, A. Joutel, C. Satizabal, R. Sacco, G. Bourque, Quentin Le Grand, M. Lathrop, T. Paus, I. Férnandez-Cadenas, Qiong Yang, B. Mazoyer, P. Boutinaud, Y. Okada, H. Grabe, K. Mather, R. Schmidt, M. Joliot, M. Ikram, F. Matsuda, C. Tzourio, J. Wardlaw, S. Seshadri, H. Adams, S. Debette   +88 more
semanticscholar   +1 more source

Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease. [PDF]

, 2016
Cerebral small vessel disease is a common condition associated with lacunar stroke, cognitive impairment and significant functional morbidity. White matter hyperintensities and brain atrophy, seen on magnetic resonance imaging, are correlated with ...
Andrew J. Lawrence, Ashburner, Christian Lambert, Curnes, Eva Zeestraten, Hugh S. Markus, Kraha, Philip Benjamin, Thomas R. Barrick, Wender   +9 more
core   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
wiley   +1 more source

Population Imaging of Cerebral Small Vessel Disease [PDF]

, 2012
As we grow older, our brain tends to shrink. We become increasingly vul nerable to dementia and stroke, two common disorders in the elderly that have great impact on brain functioning and the way people live their lives.
Poels, M.M.F. (Mariëlle)
core   +1 more source

Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan, María A. Piedrabuena, María A. Zarate, Sofía Rodríguez Murúa, Ezequiel I. Surace, Mauricio F. Farez, Marcela P. Fiol, María C. Ysrraelit, Jorge Correale   +8 more
wiley   +1 more source

Cognitive impairment in cerebral small vessel disease induced by hypertension

Neural Regeneration Research
Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease, the most common cerebrovascular disease.
Weipeng Wei, Denglei Ma, Lin Li, Lan Zhang   +3 more
doaj   +1 more source

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Brain : a journal of neurology, 2022
Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited.
A. Mishra, C. Duplàa, D. Vojinovic, Hideaki Suzuki, M. Sargurupremraj, Nuno R Zilhao, Shuo Li, Traci M. Bartz, X. Jian, Wei Zhao, E. Hofer, K. Wittfeld, S. Harris, Sandra van der Auwera-Palitschka, M. Luciano, J. Bis, H. Adams, C. Satizabal, R. Gottesman, P. Gampawar, R. Bülow, S. Weiss, Miao Yu, M. Bastin, O. Lopez, M. Vernooij, A. Beiser, U. Völker, T. Kacprowski, A. Soumaré, Jennifer A. Smith, D. Knopman, Z. Morris, Yicheng Zhu, J. Rotter, C. Dufouil, M. V. Valdés Hernández, S. Muñoz Maniega, M. Lathrop, E. Boerwinkle, R. Schmidt, M. Ihara, B. Mazoyer, Qiong Yang, A. Joutel, E. Tournier-Lasserve, L. Launer, I. Deary, T. Mosley, P. Amouyel, C. DeCarli, B. Psaty, C. Tzourio, S. Kardia, H. Grabe, A. Teumer, C. V. van Duijn, H. Schmidt, J. Wardlaw, M. A. Ikram, M. Fornage, V. Gudnason, S. Seshadri, P. Matthews, W. Longstreth, T. Couffinhal, S. Debette   +66 more
semanticscholar   +1 more source

Contributions of Aging to Cerebral Small Vessel Disease [PDF]

Annual Review of Physiology, 2020
Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related reductions in brain health.
Frank M. Faraci, T. Michael De Silva
openaire   +2 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Blood–brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study

GeroScience, 2021
Blood–brain barrier (BBB) dysfunction is one of the pathophysiological mechanisms in cerebral small vessel disease (SVD). Previously, it was shown that BBB leakage volume is larger in patients with SVD compared with controls.
Danielle Kerkhofs, S. Wong, Eleana Zhang, Renske Uiterwijk, E. Hoff, J. Jansen, J. Staals, W. Backes, R. V. van Oostenbrugge   +8 more
semanticscholar   +1 more source