Results 71 to 80 of about 265,507 (241)

Carotid Atherosclerotic Markers in CADASIL [PDF]

, 2011
Purpose: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease caused by mutations of the NOTCH3 gene. Marked variations in disease severity have raised the hypothesis that
Aout, Mounir, Chabriat, Hugues, Dichgans, Martin, Düring, Marco, Mawet, Jerome, Touboul, Pierre Jean, Vahedi, Katayoun, Vicaut, Eric   +7 more
core   +1 more source

The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants

Alzheimer's Research & Therapy
Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common pathogenesis for dementia.
Hui Hong, L. Hong, Xiao Luo, Qingze Zeng, Kaicheng Li, Shuyue Wang, Yeerfan Jiaerken, Ruiting Zhang, Xinfeng Yu, Yao Zhang, C. Lei, Zhirong Liu, Yanxing Chen, Peiyu Huang, Minming Zhang   +14 more
semanticscholar   +1 more source

Cerebral small vessel disease genomics and its implications across the lifespan

Nature Communications, 2020
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor.
M. Sargurupremraj, Hideaki Suzuki, X. Jian, C. Sarnowski, T. Evans, J. Bis, G. Eiriksdottir, S. Sakaue, N. Terzikhan, Mohamad Habes, Wei Zhao, N. Armstrong, E. Hofer, L. Yanek, S. Hagenaars, Rajan B. Kumar, E. B. van den Akker, Rebekah E. McWhirter, S. Trompet, A. Mishra, Y. Saba, C. Satizabal, G. Beaudet, L. Petit, A. Tsuchida, L. Zago, Sabrina Schilling, S. Sigurdsson, R. Gottesman, C. Lewis, N. Aggarwal, O. Lopez, Jennifer A. Smith, M. V. Valdés Hernández, J. van der Grond, M. Wright, M. Knol, M. Dörr, R. Thomson, Constance Bordes, Quentin Le Grand, Marie-Gabrielle Duperron, A. Smith, D. Knopman, P. Schreiner, Denis A. Evans, J. Rotter, A. Beiser, S. M. Maniega, M. Beekman, J. Trollor, D. Stott, Meike W. Vernooij, K. Wittfeld, W. Niessen, Aicha Soumaré, E. Boerwinkle, S. Sidney, S. Turner, G. Davies, A. Thalamuthu, U. Völker, M. van Buchem, R. Bryan, J. Dupuis, M. Bastin, D. Ames, A. Teumer, P. Amouyel, J. Kwok, R. Bülow, I. Deary, P. Schofield, H. Brodaty, Jiyang Jiang, Y. Tabara, K. Setoh, S. Miyamoto, Kazumichi Yoshida, M. Nagata, Y. Kamatani, F. Matsuda, B. Psaty, D. Bennett, P. D. De Jager, T. Mosley, P. Sachdev, R. Schmidt, H. Warren, E. Evangelou, David Trégouët, Philippe Mariza Saonli Claudine Jennifer A. Daniel I. Jean- Amouyel de Andrade Basu Berr Brody Chasman Dartigu, P. Amouyel, M. de Andrade, S. Basu, C. Berr, J. Brody, D. Chasman, J. Dartigues, A. Folsom, M. Germain, H. D. de Haan, J. Heit, J. Houwing-Duitermaat, C. Kabrhel, P. Kraft, G. Legal, S. Lindström, R. Monajemi, P. Morange, B. Psaty, P. Reitsma, P. Ridker, L. Rose, F. Rosendaal, N. Saut, E. Slagboom, D. Smadja, N. Smith, P. Suchon, Weihong Tang, K. Taylor, David Trégouët, Christophe Tzourio, M. D. de Visser, A. van Hylckama Vlieg, L. Weng, K. Wiggins, Padhraig Verneri Bendik S. Priit Tonu Tune H. Kai-How Ester Gormley Anttila Winsvold Palta Esko Pers Farh Cuen, P. Gormley, V. Anttila, B. Winsvold, P. Palta, T. Esko, T. Pers, Kai-How Farh, E. Cuenca-León, M. Muona, N. Furlotte, T. Kurth, A. Ingason, George Mcmahon, L. Ligthart, G. Terwindt, M. Kallela, T. Freilinger, C. Ran, S. Gordon, Anine H. Stam, S. Steinberg, G. Borck, M. Koiranen, L. Quaye, H. Adams, T. Lehtimäki, A. Sarin, J. Wedenoja, D. Hinds, J. Buring, M. Schürks, P. Ridker, Maria Gudlaug Hrafnsdottir, H. Stefánsson, S. Ring, J. Hottenga, B. Penninx, M. Färkkilä, V. Artto, M. Kaunisto, Salli Vepsäläinen, R. Malik, A. Heath, P. Madden, N. G. Martin, G. Montgomery, M. Kurki, M. Kals, R. Mägi, K. Pärn, E. Hämäläinen, Hailiang Huang, Andrea Byrnes, L. Franke, Jie Huang, E. Stergiakouli, Phil H. Lee, C. Sandor, C. Webber, Zameel M. Cader, Bertram Muller-Myhsok, Stefan Schreiber, T. Meitinger, Johan Eriksson, V. Salomaa, K. Heikkilä, E. Loehrer, A. Uitterlinden, A. Hofman, Cornelia M. van Duijn, L. Cherkas, L. Pedersen, A. Stubhaug, C. Nielsen, M. Männikkö, E. Mihailov, L. Milani, H. Göbel, A. Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, T. Werge, J. Kaprio, A. Aromaa, O. Raitakari, M. Ikram, T. Spector, M. Järvelin, A. Metspalu, C. Kubisch, D. Strachan, M. Ferrari, A. C. Belin, M. Dichgans, M. Wessman, A. M. van den Maagdenberg, J. Zwart, D. Boomsma, G. Davey Smith, K. Stefánsson, N. Eriksson, M. Daly, B. Neale, Jes Olesen, D. Chasman, D. Nyholt, A. Palotie, M. Ikram, W. Wen, C. DeCarli, V. Srikanth, J. Jukema, E. Slagboom, S. Kardia, Y. Okada, B. Mazoyer, J. Wardlaw, P. Nyquist, K. Mather, H. Grabe, H. Schmidt, Cornelia M. van Duijn, V. Gudnason, W. Longstreth, L. Launer, M. Lathrop, S. Seshadri, Christophe Tzourio, H. Adams, P. Matthews, M. Fornage, S. Debette   +260 more
semanticscholar   +1 more source

Inflammatory biomarkers and cerebral small vessel disease: a community-based cohort study

Stroke and vascular neurology, 2022
Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease (CSVD), previous findings remain largely inconclusive and vary according to disease status and study designs. The present study
Dingding Zhang, Yuan Cao, Jingwei Mu, Yiming Liu, F. Gao, F. Han, F. Zhai, Li-xin Zhou, J. Ni, M. Yao, Ming-Li Li, Zheng-Yu Jin, Shu-yang Zhang, L. Cui, Yong Shen, Yicheng Zhu   +15 more
semanticscholar   +1 more source

Dawson's Fingers in Cerebral Small Vessel Disease

Frontiers in Neurology, 2020
To explore Dawson's fingers in cerebral small vessel disease (CSVD) and factors related to the development of Dawson's finger, we collected and analyzed clinical data of 65 patients with CSVD. We found a venous abnormality feature called Dawson's fingers
Aowei Lv, Zaiqiang Zhang, Ying Fu, Yaping Yan, Li Yang, Wenli Zhu   +5 more
doaj   +1 more source

Cerebral small vessel disease, medial temporal lobe atrophy and cognitive status in patients with ischaemic stroke and transient ischaemic attack [PDF]

, 2017
BACKGROUND AND PURPOSE: Small vessel disease (SVD) and Alzheimer's disease (AD) are two common causes of cognitive impairment and dementia, traditionally considered as distinct processes.
Ali, M, Arba, F, Hankey, GJ, Inzitari, D, Lees, KR, Quinn, T, VISTA Collaboration,   +6 more
core   +2 more sources

Pathophysiology of cerebral small vessel disease: a journey through recent discoveries

Journal of Clinical Investigation
Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related small vessel pathologies that affect multiple regions. Disease manifestations range from lesions incidentally detected on neuroimaging (white matter hyperintensities ...
N. Dupré, Antoine Drieu, A. Joutel
semanticscholar   +1 more source

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

Nature Communications, 2020
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three MRI markers of the disease in UK Biobank imaging data and other sources: white matter ...
E. Persyn, K. Hanscombe, J. Howson, C. Lewis, M. Traylor, H. Markus   +5 more
semanticscholar   +1 more source

The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

International Journal of Stroke, 2022
Background: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries.
B. Lam, Yuan Cai, R. Akinyemi, G. Biessels, H. van den Brink, Christopher L H Chen, Chin-Nang Cheung, King Ngai Chow, Henry Chung, Marco Duering, S. T. Fu, Deb Gustafson, S. Hilal, V. Hui, R. Kalaria, Sangyun Kim, M. Lam, F. de Leeuw, A. Li, H. Markus, A. Marseglia, Huijing Zheng, J. O'Brien, L. Pantoni, P. Sachdev, E. Smith, J. Wardlaw, Vincent C T Mok   +27 more
semanticscholar   +1 more source

Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia.
Yuhui Ma, Yan Han
doaj   +1 more source