Results 81 to 90 of about 265,507 (241)

Evolving Concept of Small Vessel Disease through Advanced Brain Imaging [PDF]

Journal of Stroke, 2015
Imaging plays a crucial role in studying and understanding cerebral small vessel disease. Several important findings have emerged from recent applications of advanced brain imaging methods.
Bo Norrving
doaj   +1 more source

Social Determinants of Health and Cerebral Small Vessel Disease: Is Epigenetics a Key Mediator?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Cerebral small vessel disease is highly prevalent, particularly in marginalized communities, and its incidence is expected to increase given the aging global population.
Livia Parodi, Ernst Mayerhofer, Kaavya Narasimhalu, Nirupama Yechoor, Mary E. Comeau, Jonathan Rosand, Carl D. Langefeld, Christopher D. Anderson   +7 more
doaj   +1 more source

Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL [PDF]

, 2014
Background and Purpose—White matter hyperintensities (WMH) on MRI are a quantitative marker for sporadic cerebral small vessel disease and are highly heritable.
Adib-Samii, P., Bevan, S., Boon, E. M. J., Bracoud, L., Chabriat, H., De Stefano, N., Dichgans, M., Dotti, M. T., Duering, M., Federico, A., Gonik, M., Herve, D., Jouvent, E., Lesnik Oberstein, S., Liem, M., Malik, R., Markus, H. S., Meitinger, T., Muller-Myhsok, B., Opherk, C., Pachai, C., Pantoni, L., Pescini, F., Pianese, L., Ragno, M., Rosand, J., Rost, N., Silvestri, S., Tournier-Lasserve, E.   +28 more
core   +1 more source

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

Lancet Neurology, 2013
Summary Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can
J. Wardlaw, Eric E. Smith, G. Biessels, C. Cordonnier, F. Fazekas, R. Frayne, R. Lindley, J. O'Brien, F. Barkhof, O. Benavente, S. Black, C. Brayne, M. Breteler, H. Chabriat, C. DeCarli, F. de Leeuw, F. Doubal, Marco Duering, Nick C Fox, S. Greenberg, V. Hachinski, I. Kilimann, V. Mok, R. V. Oostenbrugge, L. Pantoni, O. Speck, B. Stephan, S. Teipel, A. Viswanathan, D. Werring, Christopher L H Chen, Colin Smith, M. van Buchem, B. Norrving, P. Gorelick, M. Dichgans   +35 more
semanticscholar   +1 more source

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

JAMA Neurology, 2022
Importance Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology.
H. Markus, W. M. van der Flier, E. Smith, P. Bath, G. Biessels, E. Briceño, Amy Brodtman, H. Chabriat, Christopher P L H Chen, F. de Leeuw, M. Egle, A. Ganesh, Marios K. Georgakis, R. Gottesman, S. Kwon, L. Launer, Vincent C. T. Mok, J. O'Brien, Lois Ottenhoff, S. Pendlebury, E. Richard, P. Sachdev, R. Schmidt, Melanie Springer, Stefan Tiedt, J. Wardlaw, A. Verdelho, A. Webb, D. Werring, Marco Duering, D. Levine, M. Dichgans   +31 more
semanticscholar   +1 more source

Linking peripheral atherosclerosis to blood–brain barrier disruption: elucidating its role as a manifestation of cerebral small vessel disease in vascular cognitive impairment

GeroScience
Aging plays a pivotal role in the pathogenesis of cerebral small vessel disease (CSVD), contributing to the onset and progression of vascular cognitive impairment and dementia (VCID). In older adults, CSVD often leads to significant pathological outcomes,
Ádám Nyúl-Tóth, Roland Patai, A. Csiszar, Anna Ungvari, Rafał Gulej, Peter Mukli, A. Yabluchanskiy, Zoltán Benyó, Péter Sótonyi, C. Prodan, Eric M. Liotta, Peter Toth, Fanny M Elahi, Péter Barsi, Pál Maurovich-Horvat, Farzaneh A. Sorond, S. Tarantini, Z. Ungvari   +17 more
semanticscholar   +1 more source

Targeting Cerebral Small Vessel Disease With MRI [PDF]

Stroke, 2017
Cerebral small vessel disease (SVD) is a severely debilitating disease affecting the smallest vessels in the brain. It is a major cause of cognitive decline, dementia, and functional disability in the elderly, and it is also responsible for ≈25% of all cerebral strokes.1,2 Still, treatment options are restricted to preventive risk management because ...
Zwanenburg, J.J.M., Osch, M.J.P. van
openaire   +3 more sources

Cognitive impairment and amygdala subregion volumes in elderly with cerebral small vessel disease: A large prospective cohort study

Neurobiology of Disease
Although the amygdala is associated with cognitive impairment resulting from cerebral small vessel disease, the relationship between alterations in amygdala structure and cerebral small vessel disease (CSVD) remains controversial. Given that the amygdala
Zhenyu Cheng, Linfeng Yang, Jing Li, Yiwen Chen, Pengcheng Liang, Yuanyuan Wang, Na Wang, Xinyue Zhang, Yian Gao, Chaofan Sui, Meng Li, Changhu Liang, Lingfei Guo   +12 more
doaj   +1 more source

Cerebral Small Vessel Disease and Alzheimer's Disease: A Review

Frontiers in Neurology, 2020
Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear pathophysiology for AD has not been confirmed, and effective treatments are still not available.
Hae Won Kim, Jeongho Hong, Jae Cheon Jeon   +2 more
doaj   +1 more source

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources