Results 61 to 70 of about 265,507 (241)

The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease

Frontiers in Aging Neuroscience, 2022
The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. The glymphatic system dysfunction, which has been demonstrated to influence cognitive impairment, can be evaluated by diffusion tensor image ...
Jie Tang, Miaoyi Zhang, Na Liu, Yang Xue, Xue Ren, Qi Huang, Langfeng Shi, Jianhui Fu   +7 more
semanticscholar   +1 more source

Advanced Neuroimaging of Cerebral Small Vessel Disease [PDF]

Current Treatment Options in Cardiovascular Medicine, 2017
Cerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in ...
Blair, Gordon W., Hernandez, Maria Valdez, Thrippleton, Michael J., Doubal, Fergus N., Wardlaw, Joanna M.   +4 more
openaire   +3 more sources

Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology.

Phytomedicine, 2022
BACKGROUND AND PURPOSE Cerebral small vessel disease (CSVD) is a clinically commonly-seen slow-progressing cerebral vascular disease. As a classic Chinese formula for the treatment of stroke, Daqinjiao Decoction (DQJD) is now used to treat CSVD with ...
Zhuoqing Wang, Ming-zhe Li, Wen-Jie Li, Jing-Feng Ouyang, Xiaojun Gou, Ying Huang   +5 more
semanticscholar   +1 more source

Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment.

Neurobiology of Disease, 2022
Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular disorders caused by the structural changes of cerebral microvessels, including the small arteries, arterioles, capillaries and venules.
Qin Yang, Xiaobo Wei, Bin Deng, Zihan Chang, Dana Jin, Yonghua Huang, John H. Zhang, M. Yenari, Kunling Jin, Qing Wang   +9 more
semanticscholar   +1 more source

Integration of Genome‐Wide Association Studies With Single‐Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have integrated genome‐wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell‐type specificity, and genetic
Yijie He, Tao Zhang, Ping Zhu, Shan Gao, Shiyang Wu, Fengzhen Liu, Yan Chen, Yingshui Yao, Guiyou Liu   +8 more
doaj   +1 more source

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]

, 2019
No abstract ...
Berry, C, Ford, TJ, Hainsworth, AH, Kaski, JC, Pereira, AC, Sidik, N, Touyz, RM   +6 more
core   +2 more sources

Contributions of Aging to Cerebral Small Vessel Disease [PDF]

Annual Review of Physiology, 2020
Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related reductions in brain health.
T Michael, De Silva, Frank M, Faraci
openaire   +2 more sources

Association of Data-Driven White Matter Hyperintensity Spatial Signatures With Distinct Cerebral Small Vessel Disease Etiologies

Neurology, 2022
Background and Objectives Topographical distribution of white matter hyperintensities (WMH) are hypothesized to vary by cerebrovascular risk factors. We used an unbiased pattern discovery approach to identify distinct WMH spatial patterns and investigate
C. Phuah, Yasheng Chen, Jeremy F. Strain, N. Yechoor, Osvaldo Laurido-Soto, B. Ances, Jin-Moo Lee   +6 more
semanticscholar   +1 more source

Lack of effect of pravastatin on cerebral blood flow or parenchymal volume loss in elderly at risk for vascular disease [PDF]

, 2005
<p><b>Background and Purpose:</b> Ageing is associated with a decline in cerebral blood flow. Animal studies have shown that cholesterol-lowering therapy with statins might preserve cerebral blood flow (CBF).
Blauw, G.J., Bollen, E.L.E.M., Box, F.M.A., de Craen, A.J.M., Murray, H.M., ten Dam, V.H., van Buchem, M.A., van den Heuvel, D.M.J., Westendorp, R.G.J.   +8 more
core   +1 more source

ESO Guideline on covert cerebral small vessel disease

European Stroke Journal, 2021
‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, and death.
J. Wardlaw, S. Debette, H. Jokinen, F. de Leeuw, L. Pantoni, H. Chabriat, J. Staals, F. Doubal, S. Rudilosso, Sebastian Eppinger, Sabrina Schilling, R. Ornello, C. Enzinger, C. Cordonnier, M. Taylor-Rowan, A. Lindgren   +15 more
semanticscholar   +1 more source