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Genetic considerations in cerebral small vessel diseases [PDF]

Frontiers in Neurology, 2023
Cerebral small vessel disease (CSVD) encompasses a broad clinical spectrum united by pathology of the small vessels of the brain. CSVD is commonly identified using brain magnetic resonance imaging with well characterized markers including covert infarcts,
Riwaj Bhagat, Sandro Marini, José R. Romero, José R. Romero   +3 more
doaj   +5 more sources

Cerebral Small Vessel Disease [PDF]

International Journal of Molecular Sciences, 2020
Cerebral small vessel disease (CSVD) represents a cluster of various vascular disorders with different pathological backgrounds. The advanced vasculature net of cerebral vessels, including small arteries, capillaries, arterioles and venules, is usually ...
J. Litak, M. Mazurek, B. Kulesza, P. Szmygin, Joanna Litak, P. Kamieniak, C. Grochowski   +6 more
semanticscholar   +9 more sources

Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study

Cerebral Circulation - Cognition and Behavior, 2021
Background: Cerebral small vessel diseases (SVDs) are a major cause of stroke and dementia. Yet, specific treatment strategies are lacking in part because of a limited understanding of the underlying disease processes.
Hilde van den Brink, Anna Kopczak, Tine Arts, Laurien Onkenhout, Jeroen C.W. Siero, Jaco J.M. Zwanenburg, Marco Duering, Gordon W. Blair, Fergus N. Doubal, Michael S. Stringer, Michael J. Thrippleton, Hugo J. Kuijf, Alberto de Luca, Jeroen Hendrikse, Joanna M. Wardlaw, Martin Dichgans, Geert Jan Biessels   +16 more
doaj   +2 more sources

Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases. [PDF]

Alzheimers Dement
We explored how blood‐brain barrier (BBB) leakage rate of gadolinium chelates (Ktrans) and BBB water exchange rate (kw) varied in cerebral small vessel disease (cSVD) subtypes.
Ying Y, Li Y, Yao T, Shao X, Tang W, Montagne A, Chabriat H, Wang DJJ, Wang C, Yang Q, Cheng X.   +10 more
europepmc   +2 more sources

Association between Computed Tomographic Biomarkers of Cerebral Small Vessel Diseases and Long-Term Outcome after Spontaneous Intracerebral Hemorrhage. [PDF]

Ann Neurol, 2021
A study was undertaken to assess whether cerebral small vessel disease (SVD) computed tomographic (CT) biomarkers are associated with long‐term outcome after intracerebral hemorrhage.
Rodrigues MA, E Samarasekera N, Lerpiniere C, Perry LA, Moullaali TJ, J M Loan J, Wardlaw JM, Al-Shahi Salman R, Lothian Audit of the Treatment of Cerebral Haemorrhage Collaborators.   +8 more
europepmc   +2 more sources

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3. [PDF]

Eur Stroke J, 2021
Background Cerebral small vessel disease is a major cause of dementia and stroke, visible on brain magnetic resonance imaging. Recent data suggest that small vessel disease lesions may be dynamic, damage extends into normal-appearing brain and ...
Clancy U, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM, Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Maniega SM, MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN, Wardlaw JM.   +26 more
europepmc   +2 more sources

Essential nutrients and cerebral small vessel diseases: a two-sample Mendelian randomization study [PDF]

Frontiers in Nutrition, 2023
BackgroundPrevious studies have suggested a potential association between nutrients and cerebral small vessel disease (CSVD), but this association has not been fully addressed.ObjectWe intended to clarify the causal associations between four categories ...
Jiayi Li, Jiayi Li, Kailin Xia, Zhengrui Wang, Zhengrui Wang, Yanru Liu, Yanru Liu, Yicheng Tong, Yicheng Tong, Yuwei Wang, Yuwei Wang, Yumou Zhou, Yumou Zhou, Linjing Zhang, Linjing Zhang, Linjing Zhang, Lu Tang, Lu Tang, Lu Tang, Dongsheng Fan, Dongsheng Fan, Dongsheng Fan, Qiong Yang   +22 more
doaj   +2 more sources

Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases. [PDF]

Alzheimers Res Ther, 2020
Background The retina and the brain share anatomic, embryologic, and physiologic characteristics. Therefore, retinal imaging in patients with brain disorders has been of significant interest. Using optical coherence tomography angiography (OCTA), a novel
Lee JY, Kim JP, Jang H, Kim J, Kang SH, Kim JS, Lee J, Jung YH, Na DL, Seo SW, Oh SY, Kim HJ.   +11 more
europepmc   +2 more sources

Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative. [PDF]

J Cereb Blood Flow Metab, 2020
Brain atrophy is increasingly evaluated in cerebral small vessel diseases. We aim at systematically reviewing the available data regarding its extent, correlates and cognitive consequences.
De Guio F, Duering M, Fazekas F, De Leeuw FE, Greenberg SM, Pantoni L, Aghetti A, Smith EE, Wardlaw J, Jouvent E.   +9 more
europepmc   +2 more sources

Cerebral small vessel disease: A review.

Advances in Clinical and Experimental Medicine, 2021
Cerebral small vessel disease (CSVD) is the most common, chronic and progressive vascular disease. The changes affect arterioles, capillaries and small veins supplying the white matter and deep structures of the brain.
J. Chojdak-Łukasiewicz, E. Dziadkowiak, A. Zimny, B. Paradowski   +3 more
semanticscholar   +4 more sources