Results 151 to 160 of about 173,118 (376)

Identification of Schwann Cells in Human Intracranial Arteries: Potential Regulatory Role in Atherosclerotic Plaque Progression

Advanced Science, EarlyView.
Schwann cells may facilitate intracranial plaque progression via neurovascular remodelingcting with vascular smooth muscle cells in atherosclerotic plaques, with the SPP1 ‐ ITGB1 signaling axis mediating this interaction as a novel mechanism. Abstract Intracranial atherosclerosis (ICAS), a common cause of ischemic stroke, remains a therapeutic ...
Zijue Wang, Yangzhige He, Weizhuang Yuan, Yijun Xia, Manqiu Ding, Zhen Chen, Naili Wang, Chao Ma, Xiaoyue Wang, Yan Xu, Weihai Xu   +10 more
wiley   +1 more source

White Matter Hyperintensities: Cerebral Small‐Vessel Diseases and White Matter Microstructural Impairments

iRADIOLOGY
White matter hyperintensities (WMH) are very widespread in older adults and are imaging features of both cerebral small‐vessel disease and white matter microstructural impairments. Recent studies have demonstrated a close association between WMH and some
Hui Huang, Wei Song, Pengyu Wang, Ye Zhu, Lei Zheng, Chenzhen Shen, Hui Xu, Jianfeng Qiu   +7 more
doaj   +1 more source

Advancing our knowledge about cerebral small vessel diseases. [PDF]

Lancet Neurol, 2023
Gorelick PB, Sorond FA.
europepmc   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia [PDF]

, 2018
BACKGROUND: Mutations in the three-prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL).
Atkinson, John P, Bertram, Paula, Hajj-Ali, Rula, Jen, Joanna C, Kolar, Grant R, Kothari, Parul H, Schmidt, Robert E   +6 more
core   +1 more source

Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]

, 2017
Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat, Applegate, Richard, Araujo, Camila, Ho, Wing Mann, Huang, Lei, Reis, Cesar, Zhang, John H   +6 more
core   +3 more sources

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Genome-wide association study of cerebral small vessel disease reveals established and novel loci.

Brain : a journal of neurology, 2019
Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations of cerebral small vessel disease, with no established preventive approaches beyond hypertension management.
Jaeyoon Chung, S. Marini, J. Pera, B. Norrving, J. Jiménez-Conde, J. Roquer, I. Férnandez-Cadenas, D. Tirschwell, M. Selim, Devin L. Brown, S. Silliman, B. Worrall, J. Meschia, S. Demel, S. Greenberg, A. Słowik, A. Lindgren, R. Schmidt, M. Traylor, M. Sargurupremraj, S. Tiedt, R. Malik, S. Debette, M. Dichgans, C. Langefeld, D. Woo, J. Rosand, C. Anderson   +27 more
semanticscholar   +1 more source

Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome. [PDF]

, 2008
Body fluid biomarkers of central nervous system damage may help improve the prognostic and diagnostic accuracy in ischemic stroke. We studied 53 patients.
Michel, P, Petzold, A, Schluep, M, Stock, M   +3 more
core   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source