Results 161 to 170 of about 8,233,957 (244)

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

Feasibility and Procedural Considerations of Balloon‐Expandable TAVR in Patients With Prior Endovascular Aortic Stent Grafts

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Objectives To evaluate the feasibility and short‐term outcomes of transcatheter aortic valve replacement (TAVR) using balloon‐expandable Sapien valves in patients with prior endovascular aortic stent grafts. Methods We conducted a single‐center, retrospective study of 23 patients with prior endovascular aortic stent grafts who underwent TAVR ...
Iad Alhallak, Alexander Mills, Beau Bequeaith, Ken Chan, Akiko Tanaka, Anthony L. Estrera, Biswajit Kar, Richard Smalling, Abhijeet Dhoble   +8 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Non‐contrast MRI reliably captures perfusion abnormalities in status epilepticus

Epilepsia, EarlyView.
Abstract Objective To determine whether non‐contrast pseudo‐continuous arterial spin labeling (pCASL) detects status epilepticus (SE)–related perfusion abnormalities and shows quantitative correspondence with dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging (MRI), and to compare single‐slice and volumetric approaches for ...
Lukas Machegger, Pilar Bosque‐Varela, Jürgen Steinbacher, Johannes Pfaff, Eugen Trinka, Giorgi Kuchukhidze   +5 more
wiley   +1 more source

<i>In vivo</i> detection of oxidative stress and iron deposition by proton exchange rate (<i>k_ex</i> ) MRI and quantitative susceptibility mapping for differentiating multiple sclerosis from cerebral small vessel diseases. [PDF]

Quant Imaging Med Surg
Hou M, Liao H, Li H, Cai Z, Zhong S, Chen W, Cai K.   +6 more
europepmc   +1 more source

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Association between electroencephalogram alpha-band oscillations and executive and processing functions in patients with cerebral small vessel diseases. [PDF]

J Cereb Blood Flow Metab
Zhao M, Hu G, Lu Y, Yang Q, Chen X, Wang D, Collet JP, Wang Y, Guan L.   +8 more
europepmc   +1 more source

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

Exploring the association between Cerebral small-vessel diseases and motor symptoms in Parkinson's disease. [PDF]

Brain Behav, 2019
Wan Y, Hu W, Gan J, Song L, Wu N, Chen Y, Liu Z.   +6 more
europepmc   +1 more source