Results 31 to 40 of about 22,186 (169)

Determinant Factors and Added Value of Osteoprotegerin (OPG) to Detect Carotid Intima-Media Thickness (CIMT) in Type 2 Diabetes Mellitus Patient

Jurnal Penyakit Dalam Indonesia, 2018
Introduction. Vascular calcification measured by carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (DM) patient is a predictor for cerebro-cardiovascular event.
Shirly Elisa Tedjasaputra, Em Yunir, Ika Prasetya Wijaya, Siti Setiati   +3 more
doaj   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

Phenotypic characteristics of the p.Asn215Ser (p.N215S) GLA mutation in male and female patients with Fabry disease: A multicenter Fabry Registry study. [PDF]

, 2018
BackgroundThe p.Asn215Ser or p.N215S GLA variant has been associated with late-onset cardiac variant of Fabry disease.MethodsTo expand on the scarce phenotype data, we analyzed natural history data from 125 p.N215S patients (66 females, 59 males ...
Brand, Eva, Burlina, Alessandro, Cecchi, Franco, Garman, Scott C, Germain, Dominique P, Jovanovic, Ana, Kempf, Judy, Laney, Dawn A, Linhart, Aleš, Maródi, László, Nicholls, Kathy, Ortiz, Alberto, Pieruzzi, Federico, Shankar, Suma P, Waldek, Stephen, Wanner, Christoph   +15 more
core   +1 more source

干预代谢危险因素对脑血管病影响的研究进展

Zhongguo cuzhong zazhi
代谢危险因素是脑血管病的重要影响因素。随着代谢性脑血管病概念的提出，如何通过干预代谢危险因素改善此类患者的预后是未来重要的研究方向。代谢危险因素可相互影响并协同作用，降压、调脂、控制血糖等对传统代谢危险因素的干预可有效降低脑血管病的发病率和复发率；抗炎、补充维生素、调节肠道菌群等对残余代谢危险因素的干预同样是影响脑血管病发病及预后的重要措施。新型代谢药物“一专多能”的特点为代谢性脑血管病的治疗和管理提供了新的思路。本综述总结干预代谢危险因素对脑血管病影响的循证医学证据 ...
张方圆, 薛婧, 许杰, 王拥军 ZHANG Fangyuan, XUE Jing, XU Jie, WANG Yongjun
doaj   +1 more source

Clinical disorders in a post war British cohort reaching retirement: evidence from the First National Birth Cohort study.

PLoS ONE, 2012
BackgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening.
Mary B Pierce, Richard J Silverwood, Dorothea Nitsch, Judith E Adams, Alison M Stephen, Wing Nip, Peter Macfarlane, Andrew Wong, Marcus Richards, Rebecca Hardy, Diana Kuh, NSHD Scientific and Data Collection Teams   +11 more
doaj   +1 more source

Congenital muscular dystrophy: from muscle to brain. [PDF]

, 2016
Congenital muscular dystrophies (CMDs) are a wide group of muscular disorders that manifest with very early onset of muscular weakness, sometime associated to severe brain involvement.The histologic pattern of muscle anomalies is typical of dystrophic ...
Corsello G, Falsaperla R, Parano E, Pavone P, Praticò AD, Rizzo R, Ruggieri M, Vitaliti G   +7 more
core   +1 more source

Causes of brain dysfunction in acute coma: a cohort study of 1027 patients in the emergency department [PDF]

, 2019
BACKGROUND: Coma of unknown etiology (CUE) is a major challenge in emergency medicine. CUE is caused by a wide variety of pathologies that require immediate and targeted treatment.
Braun, Mischa, Lindner, Tobias, Lutz, Maximilian, Möckel, Martin, Ploner, Christoph J., Schmidt, Wolf Ulrich   +5 more
core   +1 more source

Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders

Journal of Lipid Research, 1997
Peroxisomal disorders arise either from defects in the biogenesis of peroxisomes or from the defective synthesis of one or more peroxisomal enzymes. These defects result in metabolic disturbances in peroxisomal beta-oxidation of various fatty acids and ...
Y Y van der Hoek, R J Wanders, A E van den Ende, H G Kraft, B R Gabel, J J Kastelein, M L Koschinsky   +6 more
doaj   +1 more source

The effects of hemodynamic lag on functional connectivity and behavior after stroke [PDF]

, 2015
Stroke disrupts the brain's vascular supply, not only within but also outside areas of infarction. We investigated temporal delays (lag) in resting state functional magnetic resonance imaging signals in 130 stroke patients scanned two weeks, three months
Corbetta, Maurizio, Ramsey, Lenny, Shulman, Gordon L, Siegel, Joshua S, Snyder, Abraham Z   +4 more
core   +1 more source

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source