Results 31 to 40 of about 4,845 (107)

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health. [PDF]

J Neurochem
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Ramires Júnior OV, Prauchner GRK, Rieder AS, Leite AKO, Farias CP, Wyse ATS.   +5 more
europepmc   +2 more sources

Humanin: a novel central regulator of peripheral insulin action. [PDF]

PLoS ONE, 2009
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD).
Radhika H Muzumdar, Derek M Huffman, Gil Atzmon, Christoph Buettner, Laura J Cobb, Sigal Fishman, Temuri Budagov, Lingguang Cui, Francine H Einstein, Aruna Poduval, David Hwang, Nir Barzilai, Pinchas Cohen   +12 more
doaj   +1 more source

Determinant Factors and Added Value of Osteoprotegerin (OPG) to Detect Carotid Intima-Media Thickness (CIMT) in Type 2 Diabetes Mellitus Patient

Jurnal Penyakit Dalam Indonesia, 2018
Introduction. Vascular calcification measured by carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (DM) patient is a predictor for cerebro-cardiovascular event.
Shirly Elisa Tedjasaputra, Em Yunir, Ika Prasetya Wijaya, Siti Setiati   +3 more
doaj   +1 more source

干预代谢危险因素对脑血管病影响的研究进展

Zhongguo cuzhong zazhi
代谢危险因素是脑血管病的重要影响因素。随着代谢性脑血管病概念的提出，如何通过干预代谢危险因素改善此类患者的预后是未来重要的研究方向。代谢危险因素可相互影响并协同作用，降压、调脂、控制血糖等对传统代谢危险因素的干预可有效降低脑血管病的发病率和复发率；抗炎、补充维生素、调节肠道菌群等对残余代谢危险因素的干预同样是影响脑血管病发病及预后的重要措施。新型代谢药物“一专多能”的特点为代谢性脑血管病的治疗和管理提供了新的思路。本综述总结干预代谢危险因素对脑血管病影响的循证医学证据 ...
张方圆, 薛婧, 许杰, 王拥军 ZHANG Fangyuan, XUE Jing, XU Jie, WANG Yongjun
doaj   +1 more source

Clinical disorders in a post war British cohort reaching retirement: evidence from the First National Birth Cohort study.

PLoS ONE, 2012
BackgroundThe medical needs of older people are growing because the proportion of the older population is increasing and disease boundaries are widening.
Mary B Pierce, Richard J Silverwood, Dorothea Nitsch, Judith E Adams, Alison M Stephen, Wing Nip, Peter Macfarlane, Andrew Wong, Marcus Richards, Rebecca Hardy, Diana Kuh, NSHD Scientific and Data Collection Teams   +11 more
doaj   +1 more source

Physical Performance and its Association with Executive Function in Latin American Older Adults: Evidence from the LatAmFINGERS Multicenter Randomized Controlled Trial

Alzheimer's &Dementia, Volume 21, Issue S6, December 2025.
Abstract Background The accelerated aging process in low‐ and middle‐income countries (LMIC) has led to an increased prevalence of non‐communicable diseases, including dementia, a leading cause of disability in Latin America and the Caribbean (LAC). Executive and physical performance dysfunction accelerates functional decline in older adults.
Myriam Gutiérrez, Alejandra Marroig, Nicole Concha, Carolina Delgado, Ana Charamelo, Pablo Burgos, Andrea Slachevsky, Sergio Dansilio, Jose Lema, Melissa Martinez, Carlos Márquez, Natalia Pozo Castro, Maira Moreno, Jacinta Bravo, Oriana Lara, Jamileth More, Natalia Acosta‐Baena, Luc¡a Crivelli, Ismael Luis Calandri, Gustavo Sevlever, David Aguillon, Ricardo Allegri, Paulo Caramelli, Ricardo Nitrini, Ana Luisa Sosa‐Ortiz, Rosa Maria Salinas‐Contreras, Claudia Kimie Suemoto, Mônica Sanches Yassuda   +27 more
wiley   +2 more sources

Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders

Journal of Lipid Research, 1997
Peroxisomal disorders arise either from defects in the biogenesis of peroxisomes or from the defective synthesis of one or more peroxisomal enzymes. These defects result in metabolic disturbances in peroxisomal beta-oxidation of various fatty acids and ...
Y Y van der Hoek, R J Wanders, A E van den Ende, H G Kraft, B R Gabel, J J Kastelein, M L Koschinsky   +6 more
doaj   +1 more source

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

Crossed cerebellar diaschisis in status epilepticus: A systematic review of the literature

Epileptic Disorders, EarlyView.
Abstract Objective Crossed cerebellar diaschisis is a neuroimaging phenomenon observed in various neurological conditions, including status epilepticus. This systematic review aims to summarize the clinical and radiological characteristics of patients developing crossed cerebellar diaschisis following status epilepticus and to discuss potential ...
Payam Tabaee Damavandi, Pilar Bosque‐Varela, Helena Barbosa Horta Santos, Bassam Al‐Fatly, Lukas Machegger, Eugen Trinka, Giorgi Kuchukhidze   +6 more
wiley   +1 more source

残余代谢危险因素与青年卒中 Residual Metabolic Risk Factors and Stroke in Young Adults

Zhongguo cuzhong zazhi
青年卒中一般指在18～50岁年龄段内发生的卒中，其发病率上升给我国带来了日益增加的社会经济负担。在探讨青年卒中的代谢危险因素时，除了传统的高血压、糖代谢异常、脂代谢异常和肥胖外，残余代谢危险因素亦不容忽视。本文重点关注了炎症、高同型半胱氨酸血症、高尿酸血症和肠道微生物群代谢产物这4种残余代谢危险因素对青年卒中的影响。炎症在青年卒中中的作用显著，与心源性脑栓塞这一重要病因的发生发展密切相关。高同型半胱氨酸血症通过影响血管内皮和凝血功能促进血栓形成，是有望预测卒中风险及预后的重要指标 ...
钱宇彤1，2，张书凡1，2，韩振翔3，吴维诚4，韩翔1，2 (QIAN Yutong1,2, ZHANG Shufan1,2, HAN Zhenxiang3, WU Weicheng4, HAN Xiang1,2 )
doaj   +1 more source