Results 21 to 30 of about 2,092 (196)

Brain‐Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research

Neural Plasticity, Volume 2022, Issue 1, 2022., 2022
Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe. Many therapies are aimed at improving functional and cognitive recovery by targeting neural repair but have encountered issues involving efficacy and drug delivery.
Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson, Gabriela Delevati Colpo   +6 more
wiley   +1 more source

Modulation of Amyloid-beta and Tau in Alzheimer's Disease Plasma Neuronal-Derived Extracellular Vesicles by Cerebrolysin (R) and Donepezil [PDF]

, 2022
Background: Plasma neuronal-derived extracellular vesicles (NDEV) contain proteins of pathological, diagnostic, and therapeutic relevance. Objective: We investigated the associations of six plasma NDEV markers with Alzheimer's disease (AD) severity ...
Aleixandre Rico, Manuel, Antón Álvarez, X.   +1 more
core   +1 more source

A Potential Notion on Alzheimer’s Disease: Nanotechnology as an Alternative Solution

Journal of Nanomaterials, Volume 2022, Issue 1, 2022., 2022
Alzheimer’s disease is an eventually destroying disease of the overaged people featured by the dynamic and gradual brain erosion because of construction of extracellular plaques in the hippocampus. It is an undertreated and underrecognized disease that is becoming a major public health concern.
Sudhir Suryakant Pange, Mohsina Patwekar, Faheem Patwekar, Saad Alghamdi, Ahmad O. Babalghith, Osama Abdulaziz, Talha Jawaid, Mehnaz Kamal, Shahana Tabassum, Jewel Mallick, Hiwa M. Ahmed   +10 more
wiley   +1 more source

Effects of Cerebrolysin® in Patients With Minimally Conscious State After Stroke: An Observational Retrospective Clinical Study

Frontiers in Neurology, 2019
Introduction: The neurotrophic drug Cerebrolysin is composed of low-molecular-weight peptides and amino acids and has been shown to have neuroprotective and neuroplastic properties.
Jun Yup Kim, Jun Yup Kim, Hyun Jung Kim, Hyun Jung Kim, Hyo Seon Choi, So Young Park, Deog Young Kim, Deog Young Kim   +7 more
doaj   +1 more source

Cerebrolysin for vascular dementia

Cochrane Database of Systematic Reviews, 2019
Although vascular dementia is the second most common cause of dementia globally, evidence-based treatments are still lacking. Cerebrolysin is a porcine brain-derived preparation that is said to have neurotrophic and neuroprotective activity. In many parts of the world Cerebrolysin, given as a series of daily intravenous infusions, is used as a ...
Shuhui, Cui, Ning, Chen, Mi, Yang, Jian, Guo, Muke, Zhou, Cairong, Zhu, Li, He   +6 more
openaire   +3 more sources

Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies. [PDF]

, 2015
BackgroundTauopathies are a group of neurodegenerative disorders with accumulation of three-repeat (3R) or four-repeat (4R) Tau. While 3R tau is found in Pick's disease and Alzheimer's disease (AD), 4R tau is more abundant in corticobasal degeneration ...
Adame, Anthony, Brandstaetter, Hemma, Florio, Jazmin, Mante, Michael, Masliah, Eliezer, Meier, Dieter, Rockenstein, Edward, Ubhi, Kiren, Winter, Stefan   +8 more
core   +1 more source

Antiplatelets and Vascular Dementia: A Systematic Review

Journal of Aging Research, Volume 2022, Issue 1, 2022., 2022
Vascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating ...
Peter Alexander, Shakthi Visagan, Sara Jawhar, Amogh Kare, Noor Issa, Reem Issa, Abbas Jawhar, Sneha Thomas, Vasavi Gorantla, Elke Bromberg   +9 more
wiley   +1 more source

Geroprotective properties of neuroprotective and neurotrophic peptides

Неврология, нейропсихиатрия, психосоматика, 2020
Objective: to elucidate whether cerebrolysin contains peptide fragments that promote geroprotection.Material and methods. The peptide composition of cerebrolysin underwent a comprehensive mass spectrometric analysis, followed by a systemic biological ...
O. A. Gromova, I. Yu. Torshin, V. G. Zgoda, A. I. Sorokin, O. V. Tikhonova   +4 more
doaj   +1 more source

Cerebrolysin Use in Patients with Liver Damage—A Translational Study

Life, 2022
The treatment of acute life-threatening events in patients suffering from chronic pathologies is problematic, as physicians need to consider multisystemic drug effects.
Shandiz Morega, Andrei Gresita, Smaranda Ioana Mitran, Madalina Iuliana Musat, Ianis Kevyn Stefan Boboc, Victor Gheorman, Ion Udristoiu, Carmen Valeria Albu, Costin Teodor Streba, Bogdan Catalin, Ion Rogoveanu   +10 more
doaj   +1 more source

Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure. [PDF]

, 2014
BackgroundAlzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation.
Adame, Anthony, Doppler, Edith, Jech, Marion, Mante, Michael, Masliah, Eliezer, Moessler, Herbert, Novak, Philipp, Patrick, Christina, Rockenstein, Edward, Trejo, Margarita, Ubhi, Kiren   +10 more
core   +2 more sources