The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural stem cells. Newborn neurons integrate into existing neuronal networks, where they play a key role in hippocampal functions, including learning and memory. In the ageing brain, neurogenic capability progressively declines while in parallel increases the risk for ...
Stefano Farioli-Vecchioli +3 more
wiley +1 more source
CEREBROLYSIN FOR ACUTE ISCHEMIC STROKE
Cerebrolysin is a mixture of low-molecular-weight peptides and amino acids derived from pigs' brain tissue, which has potential neuroprotective and neurotrophic properties. It is widely used in the treatment of acute ischaemic stroke in Russia, China, and other Asian and post-Soviet countries.To assess the benefits and risks of Cerebrolysin for ...
Ziganshina L., Abakumova T.
openaire +6 more sources
Pharmacological management of immune and oxidative disturbances in patients with encephalopathy on the background of hypertension [PDF]
Inclusion of a comprehensive drug treatment of patients with discirculatory encephalopathy cerebrolysin combination with meksidol normalizes the concentration of C3 and C4 components of the complement system, IgG, malondialdehyde, catalase activity ...
Bistrova, N. A. +2 more
core +2 more sources
The Role of Cerebrolysin in Promoting Axonal Regeneration and Functional Recovery after Peripheral Nerve Injury: A Focus on Macrophage Activation [PDF]
Purpose: The research investigated the neuroprotective properties of Cerebrolysin regarding functional recovery, axonal regeneration, and macrophage polarization in a rat model of acute sciatic nerve damage.
Aida Karimian +4 more
doaj +1 more source
Effect of cerebrolysin on oxidative stress-induced apoptosis in an experimental rat model of myocardial ischemia [PDF]
Apoptosis plays a role in the process of tissue damage after myocardial infarction (MI). This study was designed to investigate the possible effect of cerebrolysin against apoptosis triggered by oxidative cell stress in myocardial ischemia induced by ...
Acikel +97 more
core +1 more source
Nanoparticle transport across the blood brain barrier [PDF]
: While the role of the blood-brain barrier (BBB) is increasingly recognized in the (development of treatments targeting neurodegenerative disorders, to date, few strategies exist that enable drug delivery of non-BBB crossing molecules directly to their ...
BELLETTI, Daniela +6 more
core +1 more source
Cerebrolysin in Patients with TBI: Systematic Review and Meta-Analysis
TBI (traumatic brain injury) is one of the most common causes of deaths and failure to return to society according to the latest statistics. Cerebrolysin is a drug approved for use in patients diagnosed with TBI.
Konrad Jarosz +4 more
doaj +1 more source
Making Waves in the Brain: What Are Oscillations, and Why Modulating Them Makes Sense for Brain Injury. [PDF]
Traumatic brain injury (TBI) can result in persistent cognitive, behavioral and emotional deficits. However, the vast majority of patients are not chronically hospitalized; rather they have to manage their disabilities once they are discharged to home ...
Gurkoff, Gene G +4 more
core +1 more source
This study is designed to determine the efficacy of Cerebrolysin treatment as an add-on therapy to mechanical thrombectomy (MT) in reducing global disability in subjects with acute ischemic stroke (AIS). We have planned a single center, prospective, open-
Jacek Staszewski +13 more
doaj +1 more source
Clinical efficacy of long-term treatment in patients with vascular dementia
To study efficacy and safety of prolonged course of cerebrolysin therapy in vascular dementia, 48 patients, aged from 59—77 years, with mild and moderate dementia have been studied.
I. A. Suvorova
doaj +1 more source

