Results 81 to 90 of about 5,647 (249)

Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy

open access: yesJournal of Lipid Research, 1968
Quantitative fatty acid compositions are reported for human cerebral gray matter glycolipids (gangliosides, cerebrosides, and cerebroside sulfates) in Alzheimer's disease (presenile dementia) and related disorders of the central nervous system.
George D. Cherayil
doaj   +1 more source

Interferon-alpha induced changes in NODDI predispose to the development of fatigue [PDF]

open access: yes, 2017
Interferon-alpha (IFN-α) is an important mediator of antiviral immune responses. It is also used clinically in the treatment of hepatitis-C infection.
Bouyagoub, S   +5 more
core   +3 more sources

The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. Part II

open access: yesPhytotherapy Research, Volume 38, Issue 11, Page 5490-5532, November 2024.
Abstract We have already published a review about the results of clinical trials evaluating the effects of selected nutraceuticals on glycemia in humans. In this second part, we describe the role of other nutraceuticals involved in dysglycemia. The available evidence showed promising hypoglycemic effects of the nutraceuticals reviewed both for their ...
Giuseppe Derosa   +2 more
wiley   +1 more source

6. Oceanapins A-F, unique branched ceramides isolated from the haplosclerid sponge Oceanapia cf. tenuis of the Coral sea [PDF]

open access: yes, 1994
A series of ceramides, called oceanapins A-F (2-7), which are unique for branching at both the sphingosine and fatty-acid chains, have been isolated as pure compounds from the haplosclerid sponge #Oceanapia$ cf. #tenuis$ of the Coral Sea.
Debitus, Cécile   +3 more
core  

The early diagnosis of Alzheimer's disease: Blood‐based panel biomarker discovery by proteomics and metabolomics

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.
Because of CSF biomarkers identified by neuroimaging techniques in the middle or late stages of AD, blood is considered as the novel biomarker resource for the early diagnosis of AD. The accurate alternations in blood could predict AD. This paper discusses potential blood‐based biomarkers identified by proteomics and metabolomics and future research ...
Yun Dong   +4 more
wiley   +1 more source

Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses

open access: yesJournal of Lipid Research, 2018
Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade glucosylceramide, a ubiquitous glycosphingolipid.
Fredj Ben Bdira   +4 more
doaj   +1 more source

Lycium barbarum Extract Enhanced Neuroplasticity and Functional Recovery in 5xFAD Mice via Modulating Microglial Status of the Central Nervous System

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.
LBE administration preserved cognition, movement, and visual function in 5xFAD mice. It reversed systemic inflammation and reduced Aβ load by enhancing microglial phagocytosis through modulating microglia into a neuroprotective state, thereby ameliorating the neurological pathology of the CNS (brain, spinal cord, and retina).
Zhongqing Sun   +5 more
wiley   +1 more source

Advances in the Chemical Analysis and Biological Activities of Chuanxiong

open access: yesMolecules, 2012
Chuanxiong Rhizoma (Chuan-Xiong, CX), the dried rhizome of <em>Ligusticum chuanxiong</em> Hort. (Umbelliferae), is one of the most popular plant medicines in the World.
Jin-Ao Duan   +3 more
doaj   +1 more source

Detergent-resistant plasma membrane proteome to elucidate microdomain functions in plant cells [PDF]

open access: yes, 2013
Although proteins and lipids have been assumed to be distributed homogeneously in the plasma membrane (PM), recent studies suggest that the PM is in fact non-uniform structure that includes a number of lateral domains enriched in specific components (i.e.
Daisuke Takahashi   +2 more
core   +1 more source

Novel metabolic and lipidomic biomarkers of sarcopenia

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 15, Issue 5, Page 2175-2186, October 2024.
Abstract Background The pathophysiology of sarcopenia is complex and multifactorial and has not been fully elucidated. The impact of resistance training and nutritional support (RTNS) on metabolomics and lipodomics in older adults with sarcopenia remains uncertain.
Wei‐Hsiang Hsu   +5 more
wiley   +1 more source

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