Results 51 to 60 of about 1,262,719 (285)

Transnasal Endoscopic Surgical Repair of Cerebrospinal Fluid(CSF) Rhinorrhea by Inferior Turbinate Grafts

Journal of Rawalpindi Medical College, 2021
Objective: The study aims to evaluate the outcomes of transnasal endoscopic surgical repair of CSF rhinorrhoea. Materials and Methods: After approval from the institutional ethical committee (DME-396-18) and patient consent, a descriptive study of 27 ...
Muhammad Saleem, Naeem ur Rehman, Raina Khan, Ashar Alamgir, Sarwat Bibi, Humaira Ahmad   +5 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Fluoroscopically-guided epidural blood patch for spontaneous intracranial hypotension

Journal of Anaesthesiology Clinical Pharmacology, 2015
We present three patients with spontaneous intracranial hypotension who failed conservative treatment and were treated with image-guided epidural blood patch close to the cerebrospinal fluid (CSF) leak site.
Manish Shah, David M Giampetro, Paul Kalapos, Julia C Caldwell   +3 more
doaj   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

The use of Hadad Flap to Decrease the Prevalence and Risk of Cerebrospinal Fluid Leak and Improve Outcome after Trans-Sphenoidal Pituitary Adenectomy 

Advanced Medical Journal
Background and objectives: In the majority of pituitary adenectomy surgeries, postoperative cerebrospinal fluid leaking is a challenge. Clinical professionals must prioritize the identification of particular risk factors and the resolution of this ...
Ranj Aso Mohammed Saeed Saeed, Ari Sami Hussain Nadhim Nadhim   +1 more
doaj   +1 more source

Spontaneous intracranial hypotension in a patient with systemic lupus erythematosus

Radiology Case Reports, 2019
: Spontaneous intracranial hypotension (SIH) associated with cerebrospinal fluid leak classically presents with postural headache. It is most commonly caused by the spontaneous dehiscence of a meningeal diverticulum or as a consequence of dural tears ...
Dan Isaac Cohen-Addad, MD, Aslan Efendizade, DO, Arkadij Grigorian, MD, Kevin Hewitt, DO, Vinodkumar Velayudhan, DO   +4 more
doaj   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Incidence and Significance of Intraoperative Cerebrospinal Fluid Leak in Endoscopic Pituitary Adenoma Surgery Using Intrathecal Fluorescein [PDF]

Zagazig University Medical Journal
Background: Cerebrospinal Fluid (CSF) leak during endonasal endoscopic pituitary adenoma surgery is an important factor that affects the way of sellar floor closure, postoperative CSF leak rate and postoperative outcome.
Hassan Abaza, Mohamed Mohamed Ahmed Metwaly, Tarek Abd el-Bary, Ahmed Hassanien Mohamed, Essam Elsayed Youssef   +4 more
doaj   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Transforaminal epidural blood patch for intractable spontaneous cerebrospinal fluid leak: a case report

JA Clinical Reports, 2017
Background Epidural blood patch (EBP) is a recognized treatment for spontaneous cerebrospinal fluid leak (SCFL) and is typically administered by the interlaminar approach.
Aki Fujiwara, Keisuke Watanabe, Keiji Hashizume, Kozue Shinohara, Michiko Fukumoto, Katsuhiro Kimoto, Masahiko Kawaguchi   +6 more
doaj   +1 more source