Results 31 to 40 of about 15,922 (213)

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Brain Health Deviation Index: A Comprehensive Brain Health Assessment Biomarker for Predicting Cognitive Decline and Polyvascular Stenosis

Brain Health, EarlyView.
ABSTRACT Assessing and quantifying brain health remains a pressing challenge, despite its importance for overall well‐being. Traditional methods that focus on isolated brain measures often fail to capture the multifaceted nature of brain health and may miss early signs of dysfunction.
Ziyang Liu, Shaodong Ding, Hao Liu, Jing Jing, Jian Cheng, Huaguang Zheng, Jiyang Jiang, Wei Wen, Zhe Zhang, Wanlin Zhu, Shiping Li, Yuesong Pan, Xueli Cai, Yijun Zhou, Chang Liu, Xia Meng, Yilong Wang, Hao Li, Yong Jiang, Haijun Niu, Nicole Kochan, Henry Brodaty, Tiemin Wei, Yubo Fan, Zixiao Li, Perminder S. Sachdev, Tao Liu, Yongjun Wang   +27 more
wiley   +1 more source

Chiari I Malformation: Review and Update of Current Treatment Options

Clinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo, Shuhei Shiino, Stephen Z. Shapiro, Brianna L. Hines, Noritaka Komune, Carmine Antonio Donofrio, Filippo Badaloni, Antonio Fioravanti, Joseph Lockwood, C. J. Bui, Aaron S. Dumont, R. Shane Tubbs   +11 more
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Intracranial electroencephalographic approaches in the intensive care unit: Safety, feasibility, and coverage

Epilepsia, EarlyView.
Abstract Objective Nonconvulsive epileptic activity is common after acute brain injury and contributes to neuronal injury and poor outcomes. Although intracranial electroencephalography (iEEG) improves detection compared with surface EEG (suEEG), it currently relies on focal recordings of epileptic dynamics.
Steven Smeijers, Mariella Segreti, Anaïs Van Hoylandt, Jeroen Gijs, Johannes van Loon, Lauranne Scheldeman, Bart Depreitere, Tom Theys   +7 more
wiley   +1 more source

Fully automated three‐dimensional deep learning‐based magnetic resonance imaging segmentation of brain cavities in epilepsy surgery

Epilepsia, EarlyView.
Abstract Objective There are several clinical and research applications for determining the amount of brain tissue resected after epilepsy surgery; however, manual segmentation of postoperative magnetic resonance imaging (MRI) is imprecise and time‐consuming.
Raphael Fernandes Casseb, Brunno Machado de Campos, Wallace Souza Loos, Marcelo Eduardo Ramos Barbosa, Marina Koutsodontis Machado Alvim, Gabriel Chagas Lutfala Paulino, Enrico Ghizoni, Francesco Pucci, Samuel Worrell, Clarissa Lin Yassuda, Roberto Medeiros de Souza, Lara Jehi, Fernando Cendes   +12 more
wiley   +1 more source

Comparison of Two Different Pulsed Radiofrequency Modes for Prevention of Postherpetic Neuralgia in Elderly Patients with Acute/Subacute Trigeminal Herpes Zoster

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Trigeminal postherpetic neuralgia (PHN) is often refractory to treatment. Pulsed radiofrequency (PRF) neuromodulation can help in preventing PHN after herpes zoster. This study aimed to compare the efficacy and safety of two different PRF modes on gasserian ganglion neuromodulation in elderly patients with acute/subacute trigeminal ...
Cheng‐Fu Wan, Tao Song
wiley   +1 more source

Novel planning pipeline utilizing the Surgical Theater system for pediatric epilepsy surgery

Epilepsia Open, EarlyView.
Abstract Objective Advances in the analysis and collation of radiographic datasets have enhanced presurgical planning for various neurosurgical procedures, including clipping of cerebral aneurysms, surgical resection of tumors, and arteriovenous malformation management.
Lisa B. E. Shields, Hunain Abri, Cemal Karakas, Shannon D. Davis, Ian S. Mutchnick   +4 more
wiley   +1 more source

Use of Free Flaps in the Reconstruction of the Ventral Skull Base: A Systematic Literature Review

Head &Neck, EarlyView.
ABSTRACT Background Reconstruction of the ventral skull base represents a challenge in head and neck surgery. When local or regional flaps are insufficient, microvascular free flaps offer a reliable reconstructive option. Methods A systematic literature review was conducted following PRISMA guidelines to identify studies on ventral skull base ...
Francesco Mazzola, Francesco Benvegnù, Milena Fior, Martina Conti, Stefano Taboni, Enzo Emanuelli, Philippe Herman, Piero Nicolai, Elisabetta Zanoletti, Raul Pellini, Marco Ferrari   +10 more
wiley   +1 more source

Surgical Treatment of Lateral Skull Base Tumors Extending to the Craniovertebral Junction

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate the clinical manifestation, surgical strategies, and long‐term outcomes of lateral skull base tumors extending to the craniovertebral junction (CVJ), with a focus on the infratemporal fossa approach (IFA) and individualized treatment options for cervical‐occipital stability.
Songbo Xue, Yang Zhao, Huiying Sun, Hanlin Chen, Yong Zhao, Xin Ding, Wanru Zheng, Fei Ren, Yiwei Zhao, Jiajing Tong, Yu Chen, Zhiqiang Gao, Xu Tian, Siyi Cai, Guodong Feng   +14 more
wiley   +1 more source