Results 61 to 70 of about 113,579 (302)

Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease

BMC Neurology, 2019
Background and aim Toxic oligomeric α-synuclein (αS; O-αS) has been suggested to play a central role in the pathogenesis of Lewy body diseases such as Parkinson’s disease (PD).
Hidetomo Murakami, Takahiko Tokuda, Omar M. A. El-Agnaf, Takuma Ohmichi, Ayako Miki, Hideaki Ohashi, Yoshiyuki Owan, Yu Saito, Satoshi Yano, Tamao Tsukie, Takeshi Ikeuchi, Kenjiro Ono   +11 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Cerebrospinal fluid microenvironment and migraine

Chinese Journal of Contemporary Neurology and Neurosurgery
Migraine is a common neurological disorder with higher prevalence and recurrence rates. As research into its mechanism progresses, processes such as neurogenic inflammation, cortical spreading depression (CSD), and trigeminovascular system activation ...
GONG Yu-hong, CHEN Jun-wei, LI Yi-fan, ZHONG Fang-tian, MO Duo, DONG Ming   +5 more
doaj   +1 more source

Review of "Proteins of the Cerebrospinal Fluid" (2^nd Edition) by Edward J. Thompson

Cerebrospinal Fluid Research, 2007
This book on cerebrospinal fluid (CSF) proteins is primarily focused on immunoglobulins. The book was written as an extension of a meeting on multiple sclerosis to provide a more extensive consideration of the CSF.
Connor James R
doaj   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

Pharmaceutics, 2014
Central nervous system (CNS) drug disposition is dictated by a drug’s physicochemical properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter ...
Raj K. Singh Badhan, Marylore Chenel, Jeffrey I. Penny   +2 more
doaj   +1 more source

Human neuroglobin protein in cerebrospinal fluid.

Proteome science, 2005
BACKGROUND: Neuroglobin is a hexacoordinated member of the globin family of proteins. It is predominantly localized to various brain regions and retina where it may play a role in protection against ischemia and nitric oxide-induced neural injury.
Casado, Begona, Pannell, Lewis K, Whalen, Gail, Clauw, Daniel J, Baraniuk, James N   +4 more
openaire   +4 more sources

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

Assessment of apoptosis with cerebrospinal fluid proteins and event related potentials in patients with mild cognitive impairment [PDF]

, 2008
Patients with mild cognitive impairment (MCI) have memory problems bigger than those expected due to aging, but do not experience any impairment in any other cognitive functions such as thought, cognition and attention or difficulties in daily life ...
Papaliagkas, Vasileios, Παπαλιάγκας, Βασίλειος   +1 more
core   +1 more source