Results 71 to 80 of about 479,876 (352)

ING116070: a study of the pharmacokinetics and antiviral activity of dolutegravir in cerebrospinal fluid in HIV-1-infected, antiretroviral therapy-naive subjects. [PDF]

, 2014
BackgroundDolutegravir (DTG), a once-daily, human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, was evaluated for distribution and antiviral activity in cerebrospinal fluid (CSF).MethodsING116070 is an ongoing, single-arm, open-label ...
Chen, Shuguang, extended ING116070 study team, Letendre, Scott L, Mills, Anthony M, Min, Sherene S, Piscitelli, Stephen C, Song, Ivy H, Tashima, Karen T, Thomas, Deborah A   +8 more
core   +3 more sources

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

Digital detection of exosomes by interferometric imaging [PDF]

, 2016
Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics.
Benussi, Luisa, Bettotti, Paolo, Chiari, Marcella, Ciani, Miriam, Cretich, Marina, Daaboul, George G., Freedman, David S., Gagni, Paola, Ghidoni, Roberta, Ozkumur, Ayca Yalcin, Piotto, Chiara, Prosperi, Davide, Santini, Benedetta, Unlu, M. Selim   +13 more
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data [PDF]

Arquivos de Neuro-Psiquiatria
Background: Increased concentrations of serum proteins in cerebrospinal fluid (CSF) are interpreted as blood-CSF barrier dysfunction. Frequently used interpretations such as barrier leakage, disruption or breakdown contradict CSF protein data, which ...
Hansotto REIBER
doaj   +2 more sources

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Kinetics-Like Equation For Cerebrospinal Fluid-Blood Diffusion Models

Revista Cubana de Investigaciones Biomédicas, 2019
Introduction: The diffusion of proteins from the blood to the cerebrospinal fluid is influenced by its molecular weight and by the intrinsic properties and biological properties of the protein.
José Alejandro Rodríguez-Pérez, Alejandro Mirabal-Viel, Vanessa Pérez-del-Vallín, Christian Meijides-Mejías, William Castillo-González, Jairo Lumpuy-Castillo, Alberto Juan Dorta-Contreras   +6 more
doaj  

Biomarcadores no líquido cefalorraquidiano para o diagnóstico precoce de doença de Parkinson.

Acta Médica Portuguesa, 2011
In current medical practice, the diagnosis of Parkinson's disease remains essentially clinical. This practice determines that the diagnosis of Parkinson's disease is done in an already advanced neuropathological stage of the disease.
Andreia Gomes da Costa, Miguel Fernandes Gago, Carolina Garrett   +2 more
doaj   +1 more source

Fibroblast growth factors 1 and 2 in cerebrospinal fluid are associated with HIV disease, methamphetamine use, and neurocognitive functioning. [PDF]

, 2016
BackgroundHuman immunodeficiency virus (HIV) and methamphetamine use commonly affect neurocognitive (NC) functioning. We evaluated the relationships between NC functioning and two fibroblast growth factors (FGFs) in volunteers who differed in HIV ...
Bharti, Ajay R, Cherner, Mariana, Ellis, Ronald J, Everall, Ian P, Grant, Igor, Heaton, Robert K, Letendre, Scott L, Masliah, Eliezer, Potter, Michael, Rosario, Debra, Woods, Steven Paul   +10 more
core   +2 more sources