Results 51 to 60 of about 479,876 (352)

Cellular Distribution of Brain Aquaporins and Their Contribution to Cerebrospinal Fluid Homeostasis and Hydrocephalus

Biomolecules, 2022
Brain aquaporins facilitate the movement of water between the four water compartments: blood, cerebrospinal fluid, interstitial fluid, and intracellular fluid.
José Luis Trillo-Contreras, Reposo Ramírez-Lorca, Javier Villadiego, Miriam Echevarría   +3 more
doaj   +1 more source

Differential neuroproteomic and systems biology analysis of spinal cord injury [PDF]

, 2016
Acute spinal cord injury (SCI) is a devastating condition with many consequences and no known effective treatment. Although it is quite easy to diagnose traumatic SCI, the assessment of injury severity and projection of disease progression or recovery ...
Bramlett, Helen M, Das, Jyotirmoy H, Dietrich, W. Dalton, Moghieb, Ahmed, Selig, Tyler, Wang, Kevin K. W, Wang, Michael S, Yang, Zhihui, Yost, Richard A   +8 more
core   +2 more sources

High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition: A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats

International Journal of Hypertension, 2013
The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β ...
Ibrahim González-Marrero, Leandro Castañeyra-Ruiz, Juan M. González-Toledo, Agustín Castañeyra-Ruiz, Hector de Paz-Carmona, Rafael Castro, Juan R. Hernandez-Fernaud, Agustín Castañeyra-Perdomo, Emilia M. Carmona-Calero   +8 more
doaj   +1 more source

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter, Kessler, C., Krause, Klaus-Henning, Reuther, R.   +3 more
core   +1 more source

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells [PDF]

, 2020
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial reactions in the ...
Cifuentes, Manuel, Claros, Silvia, García-Bonilla, María, García-Martín, María L., Gutiérrez, Antonia, Jiménez, Antonio J., Jiménez, Sebastián, Muñoz-Hernández, M Carmen, Ojeda-Pérez, Betsaida, Páez-González, Patricia, Santos-Ruíz, Leonor, Shumilov, Kirill, Vitorica, Javier   +12 more
core   +2 more sources

Proteins released from degenerating neurons are surrogate markers for acute brain damage

Neurobiology of Disease, 2004
The experimental and clinical study of degenerative brain disorders would benefit from new surrogate markers for brain damage. To identify novel candidate markers for acute brain injury, we report that rat cortical neurons release over 60 cytoskeletal ...
Robert Siman, Tracy K McIntosh, Kristie M Soltesz, Zhaoming Chen, Robert W Neumar, Victoria L Roberts   +5 more
doaj   +1 more source

Cerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington's disease.

PLoS ONE, 2020
Molecular markers derived from cerebrospinal fluid (CSF) represent an accessible means of exploring the pathobiology of Huntington's disease (HD) in vivo.
Alexander J Lowe, Simon Sjödin, Filipe B Rodrigues, Lauren M Byrne, Kaj Blennow, Rosanna Tortelli, Henrik Zetterberg, Edward J Wild   +7 more
doaj   +1 more source

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. [PDF]

, 2015
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at ...
Andreas Weiss, Benjamini, Blair R. Leavitt, Douglas Langbehn, Douglas Macdonald, Edward J. Wild, Henrik Zetterberg, James R.C. Miller, Jeromin, Ko, Lewczuk, Nicola Robertson, Rainer Kuhn, Roberto Boggio, Rosengren, Salman Haider, Sarah J. Tabrizi   +16 more
core   +1 more source

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

Nature Aging
Alzheimer’s disease (AD) is heterogenous at the molecular level. Understanding this heterogeneity is critical for AD drug development. Here we define AD molecular subtypes using mass spectrometry proteomics in cerebrospinal fluid, based on 1,058 proteins,
B. Tijms, Ellen M. Vromen, O. Mjaavatten, H. Holstege, L. Reus, S. J. van der Lee, K. Wesenhagen, L. Lorenzini, L. Vermunt, V. Venkatraghavan, N. Tesi, Jori Tomassen, Anouk den Braber, Julie Goossens, E. Vanmechelen, F. Barkhof, Y. Pijnenburg, W. M. van der Flier, C. Teunissen, F. Berven, P. Visser   +20 more
semanticscholar   +1 more source