Results 31 to 40 of about 113,579 (302)

Cellular Distribution of Brain Aquaporins and Their Contribution to Cerebrospinal Fluid Homeostasis and Hydrocephalus

Biomolecules, 2022
Brain aquaporins facilitate the movement of water between the four water compartments: blood, cerebrospinal fluid, interstitial fluid, and intracellular fluid.
José Luis Trillo-Contreras, Reposo Ramírez-Lorca, Javier Villadiego, Miriam Echevarría   +3 more
doaj   +1 more source

High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition: A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats

International Journal of Hypertension, 2013
The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β ...
Ibrahim González-Marrero, Leandro Castañeyra-Ruiz, Juan M. González-Toledo, Agustín Castañeyra-Ruiz, Hector de Paz-Carmona, Rafael Castro, Juan R. Hernandez-Fernaud, Agustín Castañeyra-Perdomo, Emilia M. Carmona-Calero   +8 more
doaj   +1 more source

Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients [PDF]

, 2002
By comparing the CSF proteome between Alzheimer disease (AD) patients and controls it may be possible to identify proteins that play a role in the disease process and thus to study the pathogenesis of AD.
Nilsson, CL, Westman-Brinkmalm, A, Sjögren, M, Paulson, L, Davidsson, P, Lindbjer, M, Andreasen, N,, Blennow, K   +7 more
core   +3 more sources

Proteins released from degenerating neurons are surrogate markers for acute brain damage

Neurobiology of Disease, 2004
The experimental and clinical study of degenerative brain disorders would benefit from new surrogate markers for brain damage. To identify novel candidate markers for acute brain injury, we report that rat cortical neurons release over 60 cytoskeletal ...
Robert Siman, Tracy K McIntosh, Kristie M Soltesz, Zhaoming Chen, Robert W Neumar, Victoria L Roberts   +5 more
doaj   +1 more source

Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]

, 2007
So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD). However, this assay cannot be used for screening because of the high rate of false-positive results,
Steinacker, Petra, Brechlin, Peter, Cepek, Lukas, Klingebiel, Enrico, Bibl, Mirko, Kretzschmar, Hans A., Mollenhauer, Brit, Otto, Markus, Wiltfang, Jens   +8 more
core   +1 more source

Cerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington's disease.

PLoS ONE, 2020
Molecular markers derived from cerebrospinal fluid (CSF) represent an accessible means of exploring the pathobiology of Huntington's disease (HD) in vivo.
Alexander J Lowe, Simon Sjödin, Filipe B Rodrigues, Lauren M Byrne, Kaj Blennow, Rosanna Tortelli, Henrik Zetterberg, Edward J Wild   +7 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

CSF/serum ratios: modern approach to assess intrathecal response

Инфекция и иммунитет
CSF/serum ratios are the quotients of protein concentrations between the cerebrospinal fluid and blood serum. This method provides an objective assessment of proteins amount and origin in the cerebrospinal fluid.
Alexandra M. Deomkina, R. F. Sayfullin, A. K. Shakaryan, O. V. Shamsheva   +3 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source