Results 11 to 20 of about 479,876 (352)

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Nature Medicine, 2020
Erik C.B. Johnson, E. Dammer, D. Duong, Lingyan Ping, Maotian Zhou, Luming Yin, L. Higginbotham, Andrew Guajardo, Bartholomew White, J. Troncoso, M. Thambisetty, T. Montine, Eddie B. Lee, J. Trojanowski, T. Beach, E. Reiman, V. Haroutunian, Minghui Wang, E. Schadt, Bin Zhang, D. Dickson, N. Ertekin-Taner, T. Golde, V. Petyuk, P. D. De Jager, D. Bennett, T. Wingo, S. Rangaraju, I. Hajjar, J. Shulman, J. Lah, A. Levey, N. Seyfried   +32 more
semanticscholar   +3 more sources

Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression

Neural Regeneration Research, 2022
Icariin (ICA) has a significant capacity to protect against depression and hippocampal injury, but it cannot effectively cross the blood-brain barrier and accumulate in the brain.
Ning-Xi Zeng, Hui-Zhen Li, Han-Zhang Wang, Kai-Ge Liu, Xia-Yu Gong, Wu-Long Luo, Can Yan, Li-Li Wu   +7 more
doaj   +1 more source

α‐Synuclein Seed Amplification Assays in the Diagnosis of Synucleinopathies Using Cerebrospinal Fluid—A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, 2023
Real‐time quaking‐induced conversion (RT‐QuIC) and protein misfolding cyclic amplification (PMCA) have been developed to detect minute amounts of amyloidogenic proteins via amplification techniques and have been used to detect misfolded α‐synuclein (αSyn)
Anna Grossauer, Greta Hemicker, F. Krismer, M. Peball, A. Djamshidian, W. Poewe, K. Seppi, B. Heim   +7 more
semanticscholar   +1 more source

A protein panel in cerebrospinal fluid for diagnostic and predictive assessment of Alzheimer’s disease

Science Translational Medicine, 2023
Alzheimer’s disease (AD) is a neurodegenerative disease with heterogenous pathophysiological changes that develop years before the onset of clinical symptoms.
Rafi U. Haque, Caroline M. Watson, Jiaqi Liu, E. K. Carter, D. Duong, J. Lah, A. Wingo, B. R. Roberts, Erik C.B. Johnson, A. Saykin, L. Shaw, N. Seyfried, T. Wingo, A. Levey   +13 more
semanticscholar   +1 more source

Estimation of cerebrospinal fluid protein [PDF]

Journal of Clinical Pathology, 1968
Three turbidometric methods and one method using ultraviolet spectrophotometry for estimating total cerebrospinal fluid protein have been examined. The necessity for preliminary dialysis renders the ultraviolet method unsuitable for routine use. The turbidometric method of Meulemans (1960) using a sulphosalicylic acid-sodium sulphate ...
C A, Pennock, L P, Passant, F G, Bolton
openaire   +2 more sources

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Nature, 2022
Macrophages are important players in the maintenance of tissue homeostasis 1 . Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma 2 , and their role in CNS physiology has not been sufficiently well studied.
Antoine Drieu, Siling Du, Steffen E. Storck, Justin Rustenhoven, Zachary Papadopoulos, Taitea Dykstra, Fenghe Zhong, Kyungdeok Kim, Susan M. Blackburn, Tornike Mamuladze, O. Harari, Celeste M. Karch, R. Bateman, R. Perrin, Martin R. Farlow, J. Chhatwal, Jared Jill Marty Bernardino Sarah Nicolas Tammie Susan V Brosch Buck Farlow Ghetti Adams Barthelemy Benzing, J. Brosch, Jill Buck, Martin R. Farlow, B. Ghetti, S. Adams, N. Barthélemy, T. Benzinger, S. Brandon, V. Buckles, Lisa Cash, Charlie Chen, J. Chua, C. Cruchaga, Darcy R. Denner, A. Dincer, Tamara Donahue, A. Fagan, B. Feldman, Shaney Flores, E. Franklin, N. Joseph-Mathurin, Alyssa R. Gonzalez, B. Gordon, Julia D. Gray, Emily Gremminger, Alexandrer Groves, Jason J Hassenstab, Cortaiga Hellm, Elizabeth M. Herries, Laura Hoechst-Swisher, D. Holtzman, Russ C. Hornbeck, Gina Jerome, S. Keefe, Deborah Koudelis, Yan Li, Jacob Marsh, Rita Martinez, K. Mawuenyega, Austin McCullough, E. McDade, J. Morris, J. Norton, Kristine E. Shady, Wendy C. Sigurdson, Jennifer C. M. Smith, Peter Wang, Qing Wang, C. Xiong, Jinbin Xu, Xiong Xu, R. Allegri, P. C. Méndez, Noelia Egido, Akihiko Araki, T. Ikeuchi, K. Ishii, K. Kasuga, Jacob Bechara, W. Brooks, P. Schofield, S. Berman, S. Goldberg, S. Ikonomovic, W. Klunk, Oscar Lopez, J. Mountz, N. Nadkarni, Riddhi Patira, Lori Smith, B. Snitz, S. Thompson, E. Weamer, Courtney Bodge, S. Salloway, Kathleen Carter, Duc Duong, Erik C.B. Johnson, Allan Levey, Lingyan Ping, N. Seyfried, Colleen D. Fitzpatrick, Helena Chui, J. Ringman, G. Day, N. Graff-Radford, M. Graham, Sochenda Stephens, Chrismary De La Cruz, J. Goldman, Arlene Mejia, Katie Neimeyer, James Noble, Anna Diffenbacher, Igor Yakushev, J. Levin, J. Vöglein, Jane Douglas, Nick C Fox, M. Grilo, C. Mummery, A. O’Connor, Bianca T Esposito, A. Goate, A. Renton, H. Fujii, M. Senda, H. Shimada, S. Gardener, Ralph M. Martins, H. Sohrabi, K. Taddei, Susanne Gräber‐Sultan, Lisa M. Häsler, Anna Hofmann, M. Jucker, S. Käser, Elke Kuder-Buletta, C. Laske, O. Preische, C. Haass, E. Morenas-Rodriguez, B. Nuscher, R. Ihara, Akem Nagamatsu, Y. Niimi, Clifford Jack, R. Koeppe, N. Mason, C. Masters, U. Obermüller, Song Hu, G. Randolph, I. Smirnov, J. Kipnis   +151 more
semanticscholar   +1 more source

Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome

bioRxiv, 2022
Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) and plasma from ...
E. Dammer, Lingyan Ping, D. Duong, Erica Modeste, N. Seyfried, J. Lah, A. Levey, Erik C.B. Johnson   +7 more
semanticscholar   +1 more source

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

Nature Neuroscience, 2022
It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the ...
Jose A. Mazzitelli, Leon C. D. Smyth, Kevin A Cross, Taitea Dykstra, Jerry Sun, Siling Du, Tornike Mamuladze, I. Smirnov, Justin Rustenhoven, J. Kipnis   +9 more
semanticscholar   +1 more source

Different Metabolomic and Proteomic Profiles of Cerebrospinal Fluid in Ventricular and Lumbar Compartments in Relation to Leptomeningeal Metastases

Metabolites, 2022
The different molecular profiles of cerebrospinal fluid (CSF) between ventricular and lumbar compartments remain elusive, especially in the context of leptomeningeal metastasis (LM), which affects CSF flow.
Ji-Woong Kwon, Ji Hye Im, Kyue-Yim Lee, Byong Chul Yoo, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Sang Hoon Shin, Heon Yoo, Ho-Shin Gwak   +9 more
doaj   +1 more source

Cerebrospinal Fluid Cytokines and Neurodegeneration‐Associated Proteins in Parkinson's Disease

Movement Disorders, 2020
Immune markers are altered in Parkinson's disease (PD), but relationships between cerebrospinal fluid (CSF) and plasma cytokines and associations with neurodegeneration‐associated proteins remain unclear.
R. Wijeyekoon, Sarah F. Moore, K. Farrell, D. P. Breen, R. Barker, C. Williams-Gray   +5 more
semanticscholar   +1 more source