Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid [PDF]
Journal of Parkinson’s Disease, 2016 Background: Clinical diagnosis of parkinsonian syndromes like Parkinson’s disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive ...
Andrea Boman +8 more
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The Relationship Between Human Cerebrospinal Fluid Proteins and the Risk of Delirium: A Study Based on Genetic Data [PDF]
Brain and BehaviorBackground Delirium is an acute cognitive disturbance that is linked to increased healthcare costs, extended hospitalization, and a greater incidence of adverse outcomes, including cognitive decline.
Zhihui Xu +6 more
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Abnormal expression of cerebrospinal fluid cation chloride cotransporters in patients with Rett syndrome. [PDF]
PLoS ONE, 2013 ObjectiveRett Syndrome is a progressive neurodevelopmental disorder caused mainly by mutations in the gene encoding methyl-CpG-binding protein 2. The relevance of MeCP2 for GABAergic function was previously documented in animal models.
Sofia Temudo Duarte +11 more
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Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma model. [PDF]
PLoS ONE, 2012 BACKGROUND: Understanding the early relationship between brain tumor cells and their environment could lead to more sensitive biomarkers and new therapeutic strategies. We have been using a rodent model of neurocarcinogenesis in which all animals develop
John C Whitin +7 more
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Laboratory Investigation of Cerebrospinal Fluid Proteins [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1990 Analysis of CSF proteins is useful in the diagnosis and management of neurological diseases in the following situations:In inflammatory conditions when there is breakdown of blood-CSF barrier integrity. Meningitis is a medical emergency, with CSF total protein measurement being only a screening test. In the detection of immune responses within the CNS.
E. Thompson, G. Keir
semanticscholar +3 more sources
bioRxiv, 2023 Cerebrospinal fluid (CSF) biomarkers reflect brain pathophysiology and are used extensively in translational research as well as in clinical practice for diagnosis of neurological diseases, e.g., Alzheimer’s disease (AD).
Linda Karlsson +9 more
semanticscholar +1 more source
Neural Regeneration Research, 2022 Adult neurogenesis is the life-long process of neural stem cell proliferation, differentiation into neurons, migration, and incorporation into the existing neuronal circuits.
Eleni Voukali, Michal Vinkler
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Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model
Frontiers in Pediatrics, 2023 IntroductionTo investigate the mechanism underlying the increased risk of subsequent neurodevelopmental disorders in children born to mothers with preeclampsia, we evaluated the neurodevelopment of offspring of a preeclampsia rat model induced by the ...
Noriyuki Nakamura +18 more
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The detection of surfactant proteins A, B, C and D in the human brain and their regulation in cerebral infarction, autoimmune conditions and infections of the CNS. [PDF]
PLoS ONE, 2013 Surfactant proteins (SP) have been studied intensively in the respiratory system. Surfactant protein A and surfactant protein D are proteins belonging to the family of collectins each playing a major role in the innate immune system.
Stefan Schob +7 more
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Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease
Nature Medicine, 2023 Proteomic analysis of cerebrospinal fluid from individuals with autosomal dominant Alzheimer’s disease reveals how this complex and chronic disease evolves over many decades.
Erik C.B. Johnson +133 more
semanticscholar +1 more source