Results 21 to 30 of about 479,876 (352)

Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

Fluids and Barriers of the CNS, 2022
Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is continuously replenished by net fluid extraction from the vasculature by the secretory action of the choroid plexus epithelium residing in each of the four ...
N. MacAulay, R. Keep, T. Zeuthen
semanticscholar   +1 more source

Cerebrospinal Fluid Protein Concentrations in Hydrocephalus

Children, 2023
CSF protein levels are altered in neurological disorders, such as hydrocephalus of different etiologies. In this retrospective observational study, we analyzed cerebrospinal fluid (CSF) samples in hydrocephalic diseases such as aqueductal stenosis (AQS, n = 27), normal pressure hydrocephalus (NPH, n = 24), hydrocephalus communicans (commHC, n = 25) and
Florian Wilhelmy, Matthias Krause, Stefan Schob, Andreas Merkenschlager, Robin Wachowiak, Wolfgang Härtig, Jürgen Meixensberger, Janina Gburek-Augustat, Tim Wende   +8 more
openaire   +3 more sources

Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s disease

Cell Reports Medicine, 2022
Summary Parkinson’s disease (PD) is a growing burden worldwide, and there is no reliable biomarker used in clinical routines to date. Cerebrospinal fluid (CSF) is routinely collected in patients with neurological symptoms and should closely reflect ...
Ozge Karayel, Sebastian Virreira Winter, S. Padmanabhan, Y. Kuras, D. Vu, I. Tuncali, Kalpana M. Merchant, A. Wills, C. Scherzer, M. Mann   +9 more
semanticscholar   +1 more source

SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

Fluids and Barriers of the CNS, 2021
Cerebrospinal fluid is a clear fluid that occupies the ventricular and subarachnoid spaces within and around the brain and spinal cord. Cerebrospinal fluid is a dynamic signaling milieu that transports nutrients, waste materials and neuroactive ...
Vania Sepúlveda, Felipe Maurelia, Maryori González, Jaime Aguayo, Teresa Caprile   +4 more
doaj   +1 more source

Development of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimer's disease.

Clinica chimica acta; international journal of clinical chemistry, 2019
Detailed knowledge of protein changes in cerebrospinal fluid (CSF) across healthy and diseased individuals would provide a better understanding of the onset and progression of neurodegenerative disorders.
A. Andersson, Julia Remnestål, B. Nellgård, H. Vunk, David Kotol, F. Edfors, M. Uhlén, J. Schwenk, L. Ilag, H. Zetterberg, K. Blennow, A. Månberg, P. Nilsson, C. Fredolini   +13 more
semanticscholar   +1 more source

Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]

, 2007
So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD). However, this assay cannot be used for screening because of the high rate of false-positive results,
Brit Mollenhauer, Enrico Klingebiel, Hans A. Kretzschmar, Harrington MG, Harrington MG, Jens Wiltfang, Jiang L, Kretzschmar HA, Lukas Cepek, Markus Otto, McKhann G, Mirko Bibl, Otto M, Peter Brechlin, Petra Steinacker, Rabilloud T, Steinhoff BJ, Will RG, Zerr I, Zheng PP   +19 more
core   +1 more source

Cerebrospinal Fluid Protein Changes in Preeclampsia [PDF]

Hypertension, 2018
The molecular mechanisms underlying seizure susceptibility in preeclampsia are unknown. We hypothesized that altered expression of distinct proteins in the cerebrospinal fluid (CSF) may reflect pathophysiological changes in the central nervous system that contribute to the neurological manifestations of severe preeclampsia. We obtained CSF
Erin, Ciampa, Yunping, Li, Simon, Dillon, Edouard, Lecarpentier, Laura, Sorabella, Towia A, Libermann, S Ananth, Karumanchi, Philip E, Hess   +7 more
openaire   +2 more sources

Sex-Related Differences in Cerebrospinal Fluid Plasma-Derived Proteins of Neurological Patients

Diagnostics, 2021
Background and aims: Cerebrospinal fluid (CSF) protein content presents a sexual dimorphism in humans. We investigated sex-related differences in CSF IgG levels and in the quantification of intrathecal IgG synthesis (IIS). Methods: CSF, serum albumin and
Massimiliano Castellazzi, Caterina Ferri, Sarah Alfiero, Ilenia Lombardo, Michele Laudisi, Ginevra Tecilla, Michela Boni, Stefano Pizzicotti, Enrico Fainardi, Tiziana Bellini, Maura Pugliatti   +10 more
doaj   +1 more source

Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]

, 2014
BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A, Loo, Rachel R Ogorzalek, Shen, Sean, Wanner, Ina-Beate   +3 more
core   +1 more source

Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]

, 2005
Background: S-100B and tau protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal ...
Barbara Ciesielczyk, Birgitt Wiese, Brit Mollenhauer, Green AJ, Hans A. Kretzschmar, Hulstaert F, Inga Zerr, Jens Wiltfang, Kretzschmar HA, Lukas Cepek, Markus Otto, Mirko Bibl, Otto M, Otto M, Petra Steinacker, Sigrid Poser, Steinhoff BJ, Walter Schulz-Schaeffer, Will RG   +18 more
core   +1 more source