Results 81 to 90 of about 183,231 (359)

APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]

, 1993
Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Beyreuther, K., Dichgans, Martin, König, G., Masters, C. L., Mönning, U., Sandbrink, R.   +5 more
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

Pharmaceutics, 2014
Central nervous system (CNS) drug disposition is dictated by a drug’s physicochemical properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter ...
Raj K. Singh Badhan, Marylore Chenel, Jeffrey I. Penny   +2 more
doaj   +1 more source

CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders. [PDF]

, 2013
β-amyloid (Aβ) plaque accumulation is a hallmark of Alzheimer's disease (AD). It is believed to start many years prior to symptoms and is reflected by reduced cerebrospinal fluid (CSF) levels of the peptide Aβ1-42 (Aβ42).
Alzheimer's Disease Neuroimaging Initiative, Insel, P, Mattsson, N, Nosheny, R, Shaw, LM, Tosun, D, Trojanowski, JQ, Weiner, M, Zetterberg, H   +8 more
core   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

A physiologically relevant blood–cerebrospinal fluid barrier model to study the permeability of neurodegenerative biomarkers

European Journal of Cell Biology
The blood–cerebrospinal fluid barrier (BCSFB) is formed by the choroid plexus and represents the interface between the blood and cerebrospinal fluid (CSF).
Petra Majerova, Krutika Khiratkar, Michaela Skrabanova, Dominika Olesova, Lubica Fialova, Kevin James, Jozef Vegh, Juraj Piestansky, Andrej Kovac   +8 more
doaj   +1 more source

Protein Level in Cerebrospinal Fluid

Clinical Chemistry, 1957
Abstract Results are given of simultaneous determinations of protein on 17 pooled cerebrospinal fluids (see Table 1) and 22 diluted sera and plasma specimens (see Table 2) by the following methods: micro-Kjeldahl; Johnston-Gibson tyrosine equivalence method; sulfosalicylic acid method; trichloroacetic acid method at 37° and two biuret ...
M U Tsao, Shirley Sethna
openaire   +1 more source

Biomarkers for Huntington's disease: an update [PDF]

, 2012
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Scahill, RI, Tabrizi, SJ, Wild, EJ
core   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Plasma neuronal specific enolase : a potential stage diagnostic marker in human African trypanosomiasis [PDF]

, 2014
© The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Mitchell, Julia A, Sternberg, Jeremy M
core   +1 more source