Results 81 to 90 of about 331,793 (319)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Arterial rigidity and cerebrovascular disorders

Неврология, нейропсихиатрия, психосоматика, 2011
Arterial rigidity (AR) is an independent cardiovascular risk factor. The strategy for primary and secondary prevention of cerebrovascular diseases involves correction of risk factors, modification of lifestyle, and the use of antihypertensive and ...
L. A. Geraskina, A. V. Fonyakin, A. R. Magomedova   +2 more
doaj   +1 more source

Effect of Low Diastolic Blood Pressure to Cardiovascular Risk in Patients With Ischemic Stroke or Transient Ischemic Attacks Under Different Systolic Blood Pressure Levels

Frontiers in Neurology, 2020
Background: In the context of recently updated strategies of pressure management, there is a paucity of evidence on the effect of diastolic blood pressure (DBP) level on adverse events among stroke patients.
Zimo Chen, Zimo Chen, Zimo Chen, Zimo Chen, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jie Xu, Jie Xu, Jie Xu, Jie Xu, Liye Dai, Liye Dai, Liye Dai, Liye Dai, Aichun Cheng, Aichun Cheng, Aichun Cheng, Aichun Cheng, Gulbahram Yalkun, Gulbahram Yalkun, Gulbahram Yalkun, Gulbahram Yalkun, Anxin Wang, Anxin Wang, Anxin Wang, Anxin Wang, Xia Meng, Xia Meng, Xia Meng, Xia Meng, Hao Li, Hao Li, Hao Li, Hao Li, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +39 more
doaj   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

The combination model of serum occludin and clinical risk factors improved the efficacy for predicting hemorrhagic transformation in stroke patients with recanalization

Heliyon
Background: and Purpose: Hemorrhagic transformation (HT) is one of the severe complications in acute ischemic stroke, especially for the patients who undergo recanalization treatment.
Shuhua Yuan, Qingfeng Ma, Chengbei Hou, Weili Li, Ke Jian Liu, Xunming Ji, Zhifeng Qi   +6 more
doaj   +1 more source

Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature

Neurobiology of Disease, 2018
Background: Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo pathological modifications during experimental epileptogenesis and in human epilepsy ...
Wendy Klement, Rita Garbelli, Emma Zub, Laura Rossini, Laura Tassi, Benoit Girard, Marine Blaquiere, Federica Bertaso, Julie Perroy, Frederic de Bock, Nicola Marchi   +10 more
doaj   +1 more source

CHRONIC CEREBROVASCULAR DISORDERS IN YOUNG PEOPLE: CLINICAL, DIAGNOSTIC, ETIOLOGICAL, PATHOGENETIC, TREATMENT AND PROPHYLACTIC ASPECTS

Клінічна та профілактична медицина, 2020
Cerebrovascular diseases remain among the world`s most pressing problems due to the high mortality, disability, reduced quality of life, development of dementia and a high risk of recurrence of cerebral circulatory disorders.
O.E. Kovalenko, B.G. Gavryshchuk
doaj   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep [PDF]

, 2018
Peer ReviewedPostprint (author's final ...
Blanco, Igor, Giraldo Giraldo, Beatriz, Gregori Pla, Clara, Solà Soler, Jordi, Zirak, Peyman   +4 more
core   +2 more sources

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source