Results 221 to 230 of about 445,834 (292)

High‐Intensity Interval Training Modulates NLRP3 Inflammasome‐Related Expression and Monocyte Subset Distribution in Adults With Obesity: A Randomised Trial

Immunology, EarlyView.
In sedentary adults with obesity, 8 weeks of high‐intensity interval training prevented the shift toward a pro‐inflammatory monocyte profile seen in nontrained controls—most robustly, a significantly lower proportion of intermediate monocytes at Week 8 (p = 0.014) while the control group also showed a within‐group rise in NLRP3 expression not observed ...
Daniela A. de Abreu, Ana Luíza P. A. Silveira, Stella de S. Vieira, Francisco A. H. Fonseca, Maria Cristina Izar, Jônatas B. do Amaral, Carolina N. França   +6 more
wiley   +1 more source

Respiration Can Trigger Cerebrovascular Reactivity: A Novel Method to Quantify Cerebrovascular Resistance Dynamics Using Real-Time Phase-Contrast MRI. [PDF]

Magn Reson Med
Liu P, Wen Q, Owashi K, Constans JM, Capel C, Balédent O.   +5 more
europepmc   +1 more source

Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis

Journal of Diabetes Investigation, EarlyView.
Liraglutide reverses hyperglycemia‐induced metabolic reprogramming in vascular smooth muscle cells, restoring mitochondrial function and AMPK/PGC‐1α signaling while suppressing mTOR activation and HIF‐1α accumulation. These changes attenuate extracellular matrix remodeling, reduce atherosclerotic plaque burden, and improve plaque stability in diabetic ...
Kun Zhu, Hanxiu Liu, Ni He, Haoyang Wang, Jing Liu, Qinhu Zhang, Zhongwei Liu   +6 more
wiley   +1 more source

FMRI Approaches to Mapping Cerebrovascular Reactivity: Comparison of Gradient Echo BOLD and Spin Echo BOLD With Arterial Spin Labeling. [PDF]

Magn Reson Med
Pomante S, Di Censo D, Caporale A, Fasano F, Zacà D, Fear EJ, Graziano F, Carriero M, Chalet LRR, Biondetti E, Caligiuri ME, Germuska M, Wise RG, Chiarelli AM.   +13 more
europepmc   +1 more source

Clinical and psychological effects of the JADEC Diabetes Card System assessed using the Problem Areas in Diabetes (PAID): A retrospective observational study

Journal of Diabetes Investigation, EarlyView.
A structured diabetes support program using a card‐based system was associated with reductions in diabetes‐related distress and improvements in glycemic control in real‐world clinical practice. These findings highlight the potential of shared‐care models to support patient‐centered diabetes management.
Yu Kouchi
wiley   +1 more source

Evaluation of cerebrovascular reactivity impairment using resting-state BOLD MRI in symptomatic patients with unilateral intracranial artery occlusion. [PDF]

Cereb Circ Cogn Behav
Shan Y, Yin YY, Cui BX, Yan SZ, Zhang Y, Yang B, Ma Y, Lu J.   +7 more
europepmc   +1 more source

Effects of age, sex, and renal function on bowel movement‐improving effects of Bifidobacterium bifidum G9‐1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study

Journal of Diabetes Investigation, EarlyView.
This prespecified subgroup analysis of the BIRDIE study demonstrated that Bifidobacterium bifidum G9‐1 improved stool consistency, bowel movement, and quality of life in patients with type 2 diabetes mellitus, chronic kidney disease, and specifically in age ≥ 65 years, male, and those with eGFR ≥60 mL/min/1.73 m2.
Fuki Ikeda, Junko Sato, Hidenori Yoshii, Hiroaki Satoh, Hirotsugu Uzawa, Daisuke Sugimoto, Reina Muto, Yuya Nishida, Hirotaka Watada   +8 more
wiley   +1 more source

Close relationship between β2‐microglobulin and type 2 diabetes‐associated peripheral neuropathy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction This study aimed to elucidate the correlation between β2‐microglobulin (β2‐MG) and peripheral neuropathy in type 2 diabetes mellitus (T2DM). Materials and Methods Diabetic peripheral neuropathy (DPN) was defined on the nerve conduction study (NCS).
Jingfang Shao, Jinpeng Xu, Lili Zhou, Panruo Jiang   +3 more
wiley   +1 more source

Correlation of breathing task derived cerebrovascular reactivity with baseline CBF, OEF and CMRO₂. [PDF]

Front Neurol
Zhang K, Triphan SMF, Wielpütz MO, Jende J, Sleight E, Ziener CH, Ladd ME, Schlemmer HP, Kauczor HU, Sedlaczek O, Kurz FT.   +10 more
europepmc   +1 more source

Habitual fasting duration and accelerated multimorbidity in older adults

Journal of Internal Medicine, EarlyView.
Abstract Background Prolonged fasting has been linked to metabolic benefits in younger adults, but its effects on chronic diseases in older populations remain unclear. Objective To examine the association between habitual fasting duration and 15‐year chronic disease accumulation in older adults, overall, within organ systems, and between age groups ...
Luis Kalmbach, David Abbad‐Gomez, Giorgi Beridze, Fernando Rodríguez‐Artalejo, Davide Liborio Vetrano, Amaia Calderón‐Larrañaga, Adrián Carballo‐Casla   +6 more
wiley   +1 more source