Results 51 to 60 of about 7,828 (111)

BVES-AS1-201-50aa interacts with the Src/mTOR pathway in CRC cells.

, 2023
(A) Vector- or ORF-wt-transfected HCT116 cells were lysed and incubated with beads-coupled anti-Flag antibody or isotype IgG. The precipitated proteins were isolated from the beads and subjected to SDS-PAGE electrophoresis before silver staining. (B) The
Weiwei Zheng (140828), Yucheng Song (14231285), Yingchang Guo (16425979), Guangtan Zhang (16425982), Xuebin Bao (16425988), Junwei Bai (9730322), Xiaofei Song (3111648), Qinhui Zhu (16425985), Chao Zhang (51048), Gang Wu (23885)   +9 more
core   +1 more source

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress [PDF]

, 2016
Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is ...
Jeffries, Kristen A., Ogretmen, Besim, Fekry, Baharan, Esmaeilniakooshkghazi, Amin, Krupenko, Natalia I., Krupenko, Sergey A.   +5 more
core   +1 more source

LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration

, 2023
CERS6 is associated with metastasis and poor prognosis in non-small cell lung cancer (NSCLC) patients through d18:1/C16:0 ceramide (C16 ceramide)-mediated cell migration, though the detailed mechanism has not been elucidated.
Siripan Limsirichaikul, Dat Quoc Tran, Yasuyoshi Mizutani, Motoshi Suzuki, Toshiyuki Takeuchi, Yoshiyuki Kawamoto, Atsuko Niimi, Patinya Sawangsri, Keiko Kano   +8 more
core   +1 more source

Targeting of CerS6 by MTX is p53-dependent.

, 2016
(A) MTX (10 nM) treatment strongly elevates CerS6 in p53+/+ but not p53-/- cells. (B) Antifolate lometrexol (LTX) bypasses p53 and does not affect CerS6: left panel, LTX inhibits both p53+/+ and p53-/- A549 cells (Experiments were performed three times ...
Natalia I. Krupenko (439696), Amin Esmaeilniakooshkghazi (846617), Baharan Fekry (846616), Sergey A. Krupenko (439695)   +3 more
core   +1 more source

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance [PDF]

, 2014
SummaryCeramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide synthase enzymes (CerS1–6). It remains unresolved whether obesity-associated alterations
Trifunovic, Aleksandra, Krönke, Martin, Brüning, Jens C., Xu, Elaine, Brönneke, Hella S., Nicholls, Hayley T., Blüher, Matthias, Wunderlich, Claudia M., Brodesser, Susanne, LoSasso, Giuseppe, Willmes, Diana M., Wunderlich, F. Thomas, Turpin, Sarah M., Hammerschmidt, Philipp, Mourier, Arnaud, Kornfeld, Jan-Wilhelm, Mauer, Jan   +16 more
core   +1 more source

Long non-coding RNA CERS6-AS1 plays a prognostic role in promoting the progression of gastric cancer. [PDF]

Bioengineered, 2021
Li Z, Liu X, Luo N, Pang Y, Hou Y, Jiang G.   +5 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Long non-coding RNA CERS6-AS1 facilitates the oncogenicity of pancreatic ductal adenocarcinoma by regulating the microRNA-15a-5p/FGFR1 axis. [PDF]

Aging (Albany NY), 2021
Yun Z, Meng F, Li S, Zhang P.
europepmc   +1 more source

N6-Methyladenosine-Modified ATP8B1-AS1 Exerts Oncogenic Roles in Hepatocellular Carcinoma via Epigenetically Activating MYC

, 2023
Chuan Tan,1,* Yanyan Huang,2,* Zheng Huang,2,* Yuanjia Ning,2 Lizheng Huang,2 Xianjian Wu,1 Yuan Lu,1 Huamei Wei,3 Jian Pu1 1Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise ...
Huang Y, Huang Z, Lu Y, Ning Y, Tan C, Pu J, Wei H, Huang L, Wu X   +8 more
core  

Important role of long non-coding RNA UBE2R2-AS1 in diabetes-induced renal injury

, 2020
Introduction The present study examined the effects and mechanisms underlying long non-coding RNA (lncRNA) UBE2R2-AS1 in diabetes-induced renal injury. Material and methods High glucose was used to imitate diabetes-induced renal injury in a cell model ...
Qianjun Luo, Sufen Li, Yanqiong Yan, Chuanqi Chen   +3 more
core   +1 more source