Results 61 to 70 of about 7,828 (111)

CerS6 is a target of MTX in mediation of antiproliferative effect.

, 2016
(A) Silencing CerS6 by siRNA rescues A549 cells from cytotoxic effect of MTX while silencing CerS4 does not change the drug toxicity. Cells were transfected with scrambled siRNA, CerS6 siRNA or CerS4 siRNA (25 pmol), MTX was added 6 h later and live ...
Natalia I. Krupenko (439696), Amin Esmaeilniakooshkghazi (846617), Baharan Fekry (846616), Sergey A. Krupenko (439695)   +3 more
core   +1 more source

Abstracts

Cancer Science, Volume 115, Issue S1, Page 1-2243, March 2024.
wiley   +1 more source

CerS6-derived sphingolipids interact with Mff and promote mitochondrial fragmentation in obesity

, 2019
Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of obesity and insulin resistance. However, the mechanistic link between these processes remained unclear.
Sprenger, H., Nolte, H., Nicholls, H., Krüger, M., Jais, A., Brügger, B., Ostkotte, D., Brüning, J., Turpin-Nolan, S., Brunner, H., Gerl, M., Langer, T., Awazawa, M., Hammerschmidt, P.   +13 more
core   +1 more source

Effects of MTX on CerS6, ceramide levels and cellular proliferation.

, 2016
(A) Levels of CerS6 (Western blot) in cancer cells with and without MTX treatment. Cells were collected 48 h after MTX was added. (B) Changes in CerS6 levels after treatment with 10 nM MTX for 48 h (calculated from A).
Natalia I. Krupenko (439696), Amin Esmaeilniakooshkghazi (846617), Baharan Fekry (846616), Sergey A. Krupenko (439695)   +3 more
core   +1 more source

Long Non-Coding RNA ZSCAN16-AS1 Promotes the Malignant Progression of Melanoma Through Regulating the miR-503-5p/ARL2 Axis

, 2023
Yuting Zhao,1 Xiangzhou Zhang,1 Jie Wang,2 Yong Li,1 Yitong Wu,1 Jisong Liu1 1Department of Plastic Surgery, the Third the People’s Hospital of Bengbu, Bengbu, Anhui, People’s Republic of China; 2Department of Plastic Surgery, Affiliated People’s ...
Li Y, Liu J, Zhang X, Wang J, Zhao Y, Wu Y   +5 more
core  

Decreased Expression of a Novel lncRNA FAM181A-AS1 is Associated with Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma

, 2022
Weiquan Liang,1,* Yiyu Lu,2,* Xingxi Pan,2,* Yunxiang Zeng,1 Weiqiang Zheng,1 Yiran Li,1 Yuanhang Nie,1 Dongbing Li,3 Dongliang Wang3 1Department of Respiratory and Critical Care Medicine, The Second People’s Hospital of Foshan (Affiliated ...
Pan X, Li Y, Liang W, Li D, Lu Y, Wang D, Zeng Y, Zheng W, Nie Y   +8 more
core  

Methotrexate induces CerS6-dependent formation of ER membrane aggregates in A549 non-small cell lung carcinoma cells.

, 2016
(A) Treatment with MTX (10 nM) resulted in the increase of autophagosome number, but CerS6 was not associated with these organelles. (B) MTX (10 nM) induced aggregation of ER membranes and the accumulation of CerS6 in the aggregates.
Natalia I. Krupenko (439696), Amin Esmaeilniakooshkghazi (846617), Baharan Fekry (846616), Sergey A. Krupenko (439695)   +3 more
core   +1 more source

Research on Correlations of lncRNA ST7-AS1 with Progression and Therapeutic Targets of Esophageal Cancer

Background/Aims: Esophageal cancer is a highly prevalent gastrointestinal tumor in China, resulting in a significant number of deaths annually. In this paper, we investigated the regulatory role and therapeutic potential of aberrant ST7-AS1 expression in
Quan Cheng, Xiao Lin, Sijia Sun, JiWen Zhang, Yan Cai   +4 more
core   +1 more source

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

, 2019
Objective: Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the ...
Bruning, Jens C., Gitte Hansen, Norbert Tennagels, Raichur, Suryaprakash, Pfenninger, Anja, Brunner, B., Larsen, Philip Just, Bielohuby, M., Wang, Bing, Bodo Brunner, Bielohuby, Maximilian, Tennagels, N., Tennagels, Norbert, Philip Just Larsen, Anja Pfenninger, Brunner, Bodo, Jens C. Bruning, Raichur, S., Maximilian Bielohuby, Wang, B., Brüning, J., Suryaprakash Raichur, Pfenninger, A., Larsen, P., Hansen, Gitte, Hansen, G., Bing Wang   +26 more
core   +1 more source

Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets. [PDF]

Turk J Med Sci, 2023
Güzel Tanoğlu E, Adigüzel S, Tanoğlu A, Aydin ZB, Hocaoğlu G, Ebinç S.   +5 more
europepmc   +1 more source