Results 141 to 150 of about 1,045,115 (361)

U.S.-EU Safe Harbor Framework; A Guide to Self-Certification [PDF]

open access: yes, 2009
[Excerpt] In this guide, we have provided an outline of the most critical pieces of the Safe Harbor Framework. The application is made available, along with a Helpful Hints Guide that explains how to fill it out.
United States Department of Commerce
core   +1 more source

Death Certificate [PDF]

open access: yesJournal of the American Geriatrics Society, 2020
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

DO-178C-based parameter data item airworthiness certification strategy

open access: yesHangkong gongcheng jinzhan
In terms of the airworthiness certification of parameter data item, domestic software manufacturers have some problems, such as unclear certification strategy and insufficient evidence of conformity.
ZHONG Xuxu   +3 more
doaj   +1 more source

PC-based aviation training devices (PCATDs): research, development and certification [PDF]

open access: yes, 2011
This paper examines the development of two PCATD’s (one helicopter, one fixed-wing) and their eventual certification by CAA. Certification has demonstrated the potential these devices have for aviation training in New Zealand.
Gilbey, Andrew   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Green Municipal Building Ordinances [PDF]

open access: yes, 2010
In 2006 the town of Babylon, NY adopted a local law that requires LEED certification for “new construction of commercial buildings, office buildings, industrial buildings, multiple residence, or senior citizen multiple residence over 4,000 square feet ...
Budniews, Donna
core   +1 more source

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