Results 71 to 80 of about 35,641 (262)

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

International validation of a urinary biomarker panel for identification of active lupus nephritis in children. [PDF]

, 2016
Conventional markers of juvenile-onset systemic lupus erythematosus (JSLE) disease activity fail to adequately identify lupus nephritis (LN). While individual novel urine biomarkers are good at detecting LN flares, biomarker panels may improve diagnostic
Beresford, MW, Corkhill, R, Ekdawy, D, Goilav, B, Jones, CA, Jorgensen, AL, Marks, SD, Midgley, A, Newland, P, Oni, L, Pilkington, C, Putterman, C, Rubinstein, T, Smith, EMD, Tullus, K, Wahezi, D   +15 more
core   +2 more sources

The Histaminase Activity of Ceruloplasmin

Experimental Biology and Medicine, 1972
SummaryThe plasmas of man and rhesus monkey contain a protein which oxidatively deaminates histamine, but not putrescine, at near physiological pH. Purified ceruloplasmin also gives this histaminase reaction. It migrates as a distinct zone in acrylamide disc electrophoresis except when complexed with anti-ceruloplasmin, indicating its identity with ...
Linda J. Rider, T J Goka, James P. Preslock, John K. Hampton   +3 more
openaire   +3 more sources

Spasmodic Dysphonia

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley   +1 more source

Comparative Analysis of Heat Exposure‐Induced Molecular Changes in Two Turtle Species with Contrasting Thermal Adaptations

Integrative Zoology, EarlyView.
Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong, Yangchun Gao, Jiaxuan Li, Yan Ge, Yufeng Wei, Youqiang Yin, Qianru Liang, Shiping Gong   +7 more
wiley   +1 more source

Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc

Case Reports in Gastrointestinal Medicine, 2019
A 30-year-old female underwent vertical sleeve gastrectomy. Postoperatively, hypercupremia and elevated ceruloplasmin were identified. Further testing revealed normal blood levels of transaminases, alkaline phosphatase, and albumin. She stopped ingestion
Timothy R. Koch, Elizabeth A. Zubowicz, John B. Gross   +2 more
doaj   +1 more source

Serum ceruloplasmin ,copper and iron levels as a risk factors for coronary heart diseases(CHD)

مجلة بغداد للعلوم, 2010
Ceruloplasmin (Cp) is one of the acute phase protein, in this review ,we studied the level of ceruloplasmin with copper (Cu) and iron in 90 patients with coronary heart diseas ( those patients are divided into three groups, whom are stable angina ...
Baghdad Science Journal
doaj   +1 more source

Six Drivers of Aging Identified Among Genes Differentially Expressed With Age

Aging Cell, EarlyView.
A meta‐analysis of 25 transcriptomic datasets from mammalian tissues revealed 45 genes consistently upregulated or downregulated with age. Orthologs of these genes were functionally evaluated using Caenorhabditis elegans lifespan screens to reveal those with causal roles in the aging process, thus identifying six evolutionarily conserved drivers of ...
Ariella Coler‐Reilly, Zachary Pincus, Erica L. Scheller, Roberto Civitelli   +3 more
wiley   +1 more source

Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response [PDF]

, 2014
Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue.
Floros, Joanna, López Barneo, José, Olmeda, Bárbara, Pascual Bravo, Alberto, Phelps, David S., Pérez Gil, Jesús, Silveyra, Patricia, Umstead, Todd M.   +7 more
core   +1 more source

Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI

British Journal of Pharmacology, EarlyView.
Background and Purpose Methanobactins are peptides with high copper affinity and potential to treat Wilson disease. We examined how two methanobactins (ARBM101 and MB‐OB3b) affected copper handling in the LPP Atp7b−/− Wilson disease rat model, compared to penicillamine or saline, by 64Cu positron emission tomography/magnetic resonance imaging ...
Emilie Munk Lynderup, Mikkel Holm Vendelbo, Frederik Teicher Kirk, Karina Højrup Vase, Aage Kristian Olsen Alstrup, Tamara Rieder, Alan A. DiSpirito, Jeremy D. Semrau, Tea Lund Laursen, Peter Ott, Hans Zischka, Thomas Damgaard Sandahl   +11 more
wiley   +1 more source