Results 51 to 60 of about 17,515 (182)

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle‐Mediated Crosstalk in Pancreatic Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang, Shafi Alenizi, Heloisa Zaccaron Milioli, Winston Lay, Saranya Pounraj, Yujie Li, Mekonnen Sisay Shiferaw, Elham Hosseini‐Beheshti, Zaklina Kovacevic   +8 more
wiley   +1 more source

Serum ceruloplasmin ,copper and iron levels as a risk factors for coronary heart diseases(CHD)

مجلة بغداد للعلوم, 2010
Ceruloplasmin (Cp) is one of the acute phase protein, in this review ,we studied the level of ceruloplasmin with copper (Cu) and iron in 90 patients with coronary heart diseas ( those patients are divided into three groups, whom are stable angina ...
Baghdad Science Journal
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Renal Activity Index for Lupus Identifies Active Renal Disease and Treatment Response in Adult Patients With Systemic Lupus Erythematosus and Lupus Nephritis

Arthritis Care &Research, Volume 78, Issue 6, Page 723-732, June 2026.
Objective We evaluated the ability of the Renal Activity Index for Lupus (RAIL) to discriminate active lupus nephritis (LN) in adult patients with active systemic lupus erythematosus (SLE) and differentiate LN treatment response. Methods Urine samples from adults with biopsy‐proven active class III and IV LN from TULIP‐LN (active LN group ...
Hermine I. Brunner, Ellen M. Cody, Prasad Devarajan, Bin Huang, Chen Chen, Dominic Sinibaldi, Madhu Ramaswamy, Jacob Knagenhjelm, Frederick Jones, Philip Z. Brohawn, Raj Tummala, Catharina Lindholm, Wendy I. White   +12 more
wiley   +1 more source

Serum copper and ceruloplasmin levels as biomarkers reflecting liver fibrosis in children with autoimmune hepatitis [PDF]

Clinical and Experimental Pediatrics
Background Clinical, biochemical, histological, and immunological indicators are frequently used to diagnose autoimmune hepatitis (AIH), a chronic inflammatory liver disease affecting children.
Salma Abdel Megeed Nagi, Mai Ibrahim Elashmawy, Amany E. Elashkar, Mohamed Zaeim Hafez, Ashraf A.E. Emara, Osama Mohammad Abdelhay, Albayoumi A.B. Fouda, Mohamed AbdelAziz Doma, Ahmad Mohamed Awad, Ahmed Mohammed Saba, Hesham Abdelrahman Ahmed, Ahmed Mohamed Gad Allah, Fatma Mahmoud Abdelraheem, Mohamed A. Gad, Mohamad A. Soliman, Tamer I. Abdalrhman, Khaled Hassaan Awad, Ismael A.K.M. El-lebedy, Mostafa M. Abdelnaser, Mohammed Z. Abdel Kareem, Marwa Fekry Hassan, Shymaa Sobhy Menshawy Khalifa   +21 more
doaj   +1 more source

The Histaminase Activity of Ceruloplasmin

Experimental Biology and Medicine, 1972
SummaryThe plasmas of man and rhesus monkey contain a protein which oxidatively deaminates histamine, but not putrescine, at near physiological pH. Purified ceruloplasmin also gives this histaminase reaction. It migrates as a distinct zone in acrylamide disc electrophoresis except when complexed with anti-ceruloplasmin, indicating its identity with ...
J K, Hampton, L J, Rider, T J, Goka, J P, Preslock   +3 more
openaire   +2 more sources

Diagnosis and treatment of hepatolenticular degeneration

Медицинский совет, 2013
Hepatolenticular degeneration (Wilson-Konovalov disease or hepatolenticular disease) is a rare hereditary disease caused by impaired copper metabolism and copper accumulation in the liver and, subsequently, in other organs.
V. V. Skvortsov, O. A. Leshina
doaj   +1 more source

Serum ceruloplasmin levels for early detection of oral precancer and oral cancer—a systematic review and meta-analysis

Journal of Oral Medicine and Oral Surgery
Introduction: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy of the head and neck region. It frequently develops from oral potentially malignant disorders such as leukoplakia and oral submucous fibrosis, both of which carry a ...
Joseph Marina, Naik Veena V.
doaj   +1 more source

TDMQ20 as A Drug Candidate for Wilson’s Disease: Comparison with D-Penicillamine, Trientine, and Tetrathiomolybdate In Vitro and In Mice

Pharmaceutics
Background/Objectives: The lifelong treatment of Wilson’s disease (WD) currently relies on copper chelators with relatively poor metal specificity, which frequently exhibit serious adverse effects.
Yingshan Zhu, Weiling Peng, Guangwei Liu, Longxin Li, Zikang Zhou, Michel Nguyen, Anne Robert, Yan Liu, Bernard Meunier   +8 more
doaj   +1 more source

Impact of Parenteral Copper and Zinc Administration on Reproduction, Inflammation, and Antioxidant Responses of Bos indicus Beef Heifers

Animals
Two experiments evaluated the effects of copper (Cu) and zinc (Zn) injection on body weight (BW), body condition score (BCS), pregnancy rate, ovarian traits, and antioxidant and inflammatory responses of beef heifers. In Exp.
Luana Gomes da Silva, Marcelo Vedovatto, Juliana Ranches, Edilane Costa Martins, Matheus Fellipe Ferreira, Eduardo de Assis Lima, Luiz Carlos Louzada Ferreira, Willian Vaniel Alves dos Reis, Gumercindo Loriano Franco   +8 more
doaj   +1 more source