Results 31 to 40 of about 1,673 (95)
Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju +3 more
wiley +1 more source
Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations
ABSTRACT Human papillomavirus (HPV), a non‐enveloped, double‐strand DNA viral pathogen, is intricately linked with the onset of various cancers, including cervical cancer and head and neck cancers. The present paper delves into HPV's ancient recognition and significant milestones such as the discovery of its role in oncogenesis and the development of ...
Fatemeh Beygnejad +4 more
wiley +1 more source
Primary Cancer Prevention Through Vaccination: Advances, Challenges, and Global Perspectives
ABSTRACT Oncogenic viral and bacterial infections constitute a significant portion of the global cancer burden, accounting for up to 15% of cases, particularly in low‐ and middle‐income countries. Prophylactic vaccination thus appears to be the most effective tool for preventing these preventable cancers, especially those linked to human papillomavirus
Christian Tague +5 more
wiley +1 more source
Superstitions on Human Papillomavirus in Africa: A Scoping Review
Africa bears a high burden of HPV‐induced diseases; this scoping review explored how superstitions and cultural beliefs fuel vaccine hesitancy. There are widespread myths and opposition from cultural/religious leaders that drive HPV vaccine hesitancy; targeted and culturally sensitive campaigns/educations are essential to improve vaccine uptake and ...
Jimoh Amzat +6 more
wiley +1 more source
Fel d 1‐Expressing Plant‐Derived Bioparticle: A Novel Treatment for Cat Allergy
This study investigates the allergenicity and immunogenicity profile of a novel plant‐derived Fel d 1 bioparticle (eBP). Fel d 1 eBP promotes immune tolerance by redirecting allergic Th2 responses toward Th1 and IL‐10–producing regulatory pathways, including Bregs.
Janice A. Layhadi +16 more
wiley +1 more source
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Complex regional pain syndrome (CRPS) is a chronic pain disorder that typically follows trauma or surgery. Suspected CRPS reported after vaccination with human papillomavirus (HPV) vaccines led to temporary suspension of proactive recommendation of HPV ...
Frank Huygen +7 more
doaj +1 more source
Biopharmaceuticals for Cancer Treatment: An Update
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath +6 more
wiley +1 more source
Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances
Jiahui Zhang,1,* Jingyi Fan,1,* Mariusz Skwarczynski,1 Rachel J Stephenson,1 Istvan Toth,1– 3 Waleed M Hussein1 1School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia; 2School of Pharmacy, The ...
Zhang J +5 more
doaj
Sustained impact of bivalent HPV immunisation on CIN incidence over two rounds of cervical screening
What's New? While vaccination against high‐risk HPV infection, the primary cause of cervical malignancy, has demonstrated long‐term effectiveness in clinical trials, real‐life longitudinal data are lacking. Here, the authors present linked long‐term screening data on the effectiveness of bivalent HPV vaccination with a minimum follow‐up of 54 months ...
Timothy J. Palmer +6 more
wiley +1 more source

