Results 141 to 150 of about 42,575 (291)
RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation
Cancer Science, EarlyView.RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu +10 more
wiley +1 more source
MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy
Cancer Science, EarlyView.MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley +1 more source
Cancer Science, EarlyView.The lncRNA CROCCP2 upregulates HOXD11 by competitively adsorbing miR‐5584‐5p, thereby promoting glioma cell proliferation, migration, and invasion by inhibiting autophagy. It significantly enhances tumor growth in vivo, suggesting it may be a potential therapeutic target for gliomas.
Feng Wang +8 more
wiley +1 more source
Atlas assimilation: a case report
, 2007 Congenital and acquired bony abnormalities of the cranio-vertebral junction may result in compression and distortion of the neural structures, vertebro-basilar vascular system, and cerebrospinal fluid channels.
Ranade, Anu +4 more
core
Cancer Science, EarlyView.Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara +21 more
wiley +1 more source
Seyrek, C. (2024). Mekanik Boyun Ağrısı Olan Kişilerde Boyun Manipülasyonu Tedavisi ve Visseral Osteopati Tekniklerinin Karşılaştırılması. Yüksek Lisans Tezi, İstanbul Atlas Üniversitesi Lisansüstü Eğitim Enstitüsü, Anabilim Dalı, İstanbul.
Seyrek, Cihat
core
Cancer Science, EarlyView.Off‐label nivolumab treatment guided by CGP results was evaluated in 56 patients with advanced solid tumors. TMB‐High was the predominant biomarker leading to nivolumab treatment. Nivolumab showed limited clinical benefit in 50 patients with measurable disease, with an ORR of 16.0%, DCR of 40.0%, median PFS of 2.7 months, and median OS of 7.2 months ...
Masashi Kanai +16 more
wiley +1 more source
Cytopathology, EarlyView.Cytology terminologies are widely accepted within Europe based on EFCS survey. The Bethesda System for reporting cervical cytology and the Bethesda System for reporting thyroid cytopathology have been implemented by most of the responding countries. ABSTRACT Cytopathologists communicate with clinicians via cytopathology reports.
Ivana Kholová +46 more
wiley +1 more source
Dens Invaginatus as a Biomechanical Risk Modifier in Dental Trauma: Finite Element Analysis
Dental Traumatology, EarlyView.ABSTRACT Introduction/Aims Traumatic dental injuries are common in childhood and may adversely affect functional and psychosocial well‐being. Dens invaginatus, a developmental anomaly caused by the infolding of the enamel organ during odontogenesis, alters tooth morphology and may influence biomechanical behavior under traumatic loading.
Emine Şuranur Ayaz +6 more
wiley +1 more source
Atlas-Axis Dislocation Following Cervical Adenitis
Cleveland Clinic Journal of Medicine, 1952 openaire +2 more sources