Results 131 to 140 of about 42,575 (291)

Bridging the Late Antique Gap in Northwest Arabia: New Archaeological Evidence on the Occupation of Wādī al‐Qurā (al‐ʿUlā [AlUla], Saudi Arabia) Between the Third and Seventh Centuries CE

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT In 2019, the Dadan Archaeological Project (CNRS/RCU/AFALULA) identified a Late Antique village 1 km south of ancient Dadan in the al‐ʿUlā valley (northwest Saudi Arabia). Three excavation seasons at this site (2021–2023) have uncovered a massive building constructed in the late third or early fourth cent.
Jérôme Rohmer, Abdulrahman Alsuhaibani, Charlène Bouchaud, Elora Chambraud, Vladimir Dabrowski, Hatem Djerbi, Fabien Lesguer, Hervé Monchot, Paul Picavet, Louise Purdue, Bertrand Riba, Shadi Shabo   +11 more
wiley   +1 more source

Type cervical vertebrae, OM GL 421, Otekaikea marplesi.

, 2014
A–E, anterior views, F–J, lateral views, K–H, dorsal views. A, F and K, atlas. B, G and L, axis. C, G and L, fourth cervical vertebra. I and N, sixth cervical vertebra. E, J and H, seventh cervical vertebra.
Yoshihiro Tanaka (143931), R. Ewan Fordyce (537770)   +1 more
core   +1 more source

New Results From the Pre‐Pottery Neolithic Site of Al Uyaynah, Tabuk, in Northwestern Saudi Arabia

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT Al Uyaynah is a low sandstone mound on an alluvial plain, long known for its extensive surface remains of stone‐built circular and rectangular structures. Following test excavations in 2012, more detailed excavation was undertaken in 2016 within one of the largest rectangular stone structures.
Khalid Alasmari, Stephanie F. Piper, Kirsten Grothe, W. Derek Hamilton, Delphine Joly, Penny Bickle, Geoff Bailey   +6 more
wiley   +1 more source

Cervical Spine Dysmorphism in Congenital Muscular Torticollis

, 2018
BACKGROUND: Congenital muscular torticollis is a common childhood musculoskeletal anomaly that might result in permanent craniofacial deformity, facial asymmetry, and changes in the cervical vertebrae, if not treated during early childhood.
이동원, 윤인식, 김용욱
core   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling

Andrology, EarlyView.
ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu, Peng Hu, Zizhong Yang, Zhenghui Jin, Xiaoyu Zhu, Tao Wang, Jihong Liu, Kai Cui   +7 more
wiley   +1 more source

Feasibility of transpedicular screw placement through the posterior arch of C1: A CT study in the Emirati population

Translational Research in Anatomy
Background: Instrumentation of the lateral mass of first cervical vertebra (C1) is required in atlantoaxial instability. C1 bears a complicated relationship with adjacent neurovascular structures such as the vertebral artery and cervical spinal cord ...
Ivan James Prithishkumar, Dineshwary Suresh, Nerissa Naidoo, Rashid AlSharhan, Usama Al Bastaki, Jeyaseelan Lakshmanan, Baylis Vivek Joseph   +6 more
doaj   +1 more source

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, EarlyView.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source