Cancer Science, EarlyView.INHBB secreted by colorectal cancer cells activates ACVR2B‐SMAD signaling to induce CD8+ T‐cell exhaustion and drive tumor progression. SB431542 blocks this oncogenic immune‐suppressive axis. ABSTRACT To investigate the expression pattern, biological functions and regulatory mechanisms of inhibin beta B (INHBB) in colorectal cancer (CRC), and to ...
Guanghui Liu +5 more
wiley +1 more source
Clinical characteristics of postoperative anterior arch fracture of the atlas following C1 laminectomy: 14-year experience of a single neurosurgical center. [PDF]
J Craniovertebr Junction SpineNagano Y +8 more
europepmc +1 more source
Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review
Clinical Genetics, EarlyView.There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson +6 more
wiley +1 more source
Nonrestrictive Fixation Strategy for Upper Cervical Spine Fractures Associated With Diffuse Idiopathic Skeletal Hyperostosis: A Case Report. [PDF]
Int J Spine SurgLi Z, Chen Y, Da Y, Hu X, He C, Zhao W.
europepmc +1 more source
Fetal brain MRI analysis: Towards clinical translation and impact
Developmental Medicine &Child Neurology, EarlyView.Emerging AI‐based methods demonstrate the feasibility of automating image acquisition, motion correction and 3D reconstruction, segmentation, biometry, and quality control in fetal brain MRI, signaling a shift towards more quantitative assessment, and enabling precise characterization and assessment of the developing brain.
Aysha Luis +3 more
wiley +1 more source
Dorsal C1-2 Spinal Cord Compression After Reduction of Atlantoaxial Posterior Dislocation Associated With Os Odontoideum: A Case Report and Literature Review. [PDF]
Orthop SurgWang J +6 more
europepmc +1 more source
Dens Invaginatus as a Biomechanical Risk Modifier in Dental Trauma: Finite Element Analysis
Dental Traumatology, EarlyView.ABSTRACT Introduction/Aims Traumatic dental injuries are common in childhood and may adversely affect functional and psychosocial well‐being. Dens invaginatus, a developmental anomaly caused by the infolding of the enamel organ during odontogenesis, alters tooth morphology and may influence biomechanical behavior under traumatic loading.
Emine Şuranur Ayaz +6 more
wiley +1 more source
The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis
The FEBS Journal, EarlyView.H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo +8 more
wiley +1 more source
Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment
The FEBS Journal, EarlyView.Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro +13 more
wiley +1 more source
Posterior Fixation Combined with Anterior Transoral Plate Osteosynthesis for Chronic Gehweiler IIIb Atlas Fracture-Dislocation: Case Report and Literature Review. [PDF]
J Clin MedShen Q +7 more
europepmc +1 more source