Results 101 to 110 of about 5,357,473 (408)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Knowledge on cervical cancer screening and vaccination among females at Oyibi Community

BMC Women's Health, 2021
Background Awareness about cervical cancer screening and vaccination in the developed countries are high as compared to the developing countries. Sixty to eighty percent (60–80%) of the women who develop cervical cancer in sub-Saharan Africa live in the ...
Evans Appiah Osei, Stella Appiah, Judith Elinam Gaogli, Ezekiel Oti-Boadi   +3 more
doaj   +1 more source

Factors Influencing Utilization of Cervical Cancer Screening Services in Kenya: the Case of Nyeri County [PDF]

, 2018
Globally, cervical cancer continues to be a major cause of mortality and morbidity among women with developing countries accounting for more than 86% of the deaths from the disease. In Kenya, cervical cancer ranks as the second most frequent cancer among
Macharia, D. (David), Wangeci, G. A. (Gichogo)   +1 more
core  

Data-Driven Cervical Cancer Prediction Model with Outlier Detection and Over-Sampling Methods

Italian National Conference on Sensors, 2020
Globally, cervical cancer remains as the foremost prevailing cancer in females. Hence, it is necessary to distinguish the importance of risk factors of cervical cancer to classify potential patients. The present work proposes a cervical cancer prediction
M. Ijaz, M. Attique, Youngdoo Son
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Cervical cancer screening : an update [PDF]

, 2012
In many countries cervical cancer is the commonest gynaecological cancer. In Malta and in the United States, it is the third most common gynaecological cancer.
Cilia Vincenti, Albert
core  

Smoking and Cervical Cancer [PDF]

ISRN Obstetrics and Gynecology, 2011
Cervical cancer (CC) is the third most common cancer in women worldwide; however, CC is a preventable disease, and much effort should be done to prevent it. Persistence of high-risk HPV infection is the strongest epidemiologic risk factor for CC, however it is not sufficient for development of the disease it cofactors should be present.
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Cervical precancer screening using self-sampling, HPV DNA testing, and mobile colposcopy in a hard-to-reach community in Ghana: a pilot study

BMC Cancer
Background The World Health Organization has set ambitious goals to eliminate cervical cancer, necessitating evidence on increasing coverage and access to screening and treatment in high-burden areas.
Kofi Effah, Ethel Tekpor, Comfort Mawusi Wormenor, John Allotey, Yaa Owusu–Agyeman, Seyram Kemawor, Dominic Agyiri, Johnpaul Amenu, Jonathan M. Gmanyami, Martin Adjuik, Kwabena Obeng Duedu, Joyce B. Der, Nana Owusu Mensah Essel, Margaret Kweku   +13 more
doaj   +1 more source

Early detection and prevention

Molecular Oncology, 2019
The rapidly increasing incidence and mortality of cancer calls for a focused effort to increase the effect of cancer‐prevention efforts. In the area of early detection, there are major differences in the preventive impact of implemented screening ...
Joakim Dillner
doaj   +1 more source