Results 51 to 60 of about 4,179,804 (295)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

SPEACx: a screening pathway-based evaluation and audit framework of cervical cancer diagnostic routes in a population-based programme

Archives of Public Health
Background Cervical cancer audits are widely used to evaluate organized screening programmes, yet existing approaches often fail to clearly attribute cancer diagnoses to specific stages of the screening pathway. This limits the ability to translate audit
David Del Valle, Edurne Arenaza Lamo, Antonia Dávila Expósito, Ángel Gómez Amorín, Elena Rodríguez Camacho, Andrea Requena Menéndez, Jose Cruz Quílez Conde, Laia Bruni Coccoz, Jhon William Comba Miranda, Silvia de Sanjosé   +9 more
doaj   +1 more source

Cervical screening in Australia 2011-2012 [PDF]

, 2014
This report presents the latest national statistics monitoring the National Cervical Screening Program, which aims to reduce incidence, morbidity and mortality from cervical cancer.

core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

HPV self-sampling implementation strategies to engage under screened communities in cervical cancer screening: a scoping review to inform screening programs

Frontiers in Public Health
IntroductionHuman papillomavirus (HPV) testing as a method of cervical cancer screening can be performed by healthcare providers or by patients through self-sampling directly in the community, removing several barriers experienced by under screened ...
Madison M. Fullerton, Madison M. Fullerton, Caitlin Ford, Chelsea D’Silva, Bonnie Chiang, Se-Inyenede Onobrakpor, Holly Dievert, Huiming Yang, Jason Cabaj, Jason Cabaj, Noah Ivers, Noah Ivers, Sandra Davidson, Jia Hu, Jia Hu, Jia Hu   +15 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Cervical cancer screening utilization and associated factors among women of 30–65 years in Girar Jarsoo district North shoa, Ethiopia, 2021

Clinical Epidemiology and Global Health, 2022
Background: Cervical cancer screening is the method of early detection of cervical cancer before occurrence to decrease mortality and morbidity of the women.
Adugna Alemu Desta, Zerfu Mulaw Endale, Mastewal Belayneh Aklil   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Experiences of cervical cancer screening in HIV-positive women in Zimbabwe

Curationis, 2021
Background: The primary purpose of screening is to detect individuals in danger of cervical cancer so as to prevent further progression of the disease.
Patience C. Mpata, Zethu Z. Nkosi
doaj   +1 more source

Human Papillomavirus and Cervical Cancer Knowledge, Perceptions, and Screening Behavior: A Cross-Sectional Community-Based Survey in Rural Philippines [PDF]

, 2020
BACKGROUND: Cervical cancer is the second most common cancer among women in the Philippines. Cervical cancer screening is an effective method to reduce incidence. However, screening utilization is limited.
Imoto, Atsuko, Llamas-Clark, Erlidia F, Honda, Sumihisa   +2 more
core   +1 more source