Results 71 to 80 of about 4,179,804 (295)

Impact of differentiating between persistent and new infections on colposcopy referral in HPV-positive triage-negative women: results from the NTCC2 study

Infectious Agents and Cancer
Background In cervical screening, human papillomavirus (HPV)-positive women at 1-year retesting are typically referred to colposcopy. This study, by the use of extended genotyping, estimates the impact of distinguishing persistent from new infections in ...
Annarosa Del Mistro, Pamela Mancuso, Francesca Carozzi, Laura De Marco, Simonetta Bisanzi, Giampaolo Pompeo, Guglielmo Ronco, Silvia Gori, Elena Allia, Daniela Gustinucci, Helena Frayle, Anna Iossa, Elena Cesarini, Simonetta Bulletti, Basilio Passamonti, Jessica Viti, Laura Toniolo, Francesco Venturelli, Paolo Giorgi Rossi, Maria Benevolo, the NTCC2 Working Group   +20 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Exploring the acceptability of two self-sampling devices for human papillomavirus testing in the cervical screening context: a qualitative study of Muslim women in London [PDF]

, 2009
Objectives We explored Muslim women's attitudes to self-sampling for human papillomavirus (HPV) in the context of cervical cancer screening and their responses to two self-sampling devices.Setting A Muslim community centre in north-east London.Methods ...
Cadman, L, Szarewski, A, Ashdown-Barr, L, Waller, J   +3 more
core  

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Scalable long-read nanopore HPV16 amplicon-based whole-genome sequencing

Scientific Reports
Human papillomavirus 16 (HPV16) drives precursor cervical lesions that often progress to cervical cancer (CC). Variation within the HPV16 genome has been associated with CC risk.
Maina K. Titus, David Giesbrecht, Cliff I. Oduor, Kapten Muthoka, Karamoko Niaré, Rebecca Crudale, Abebe A. Fola, Sin Ting Hui, Isaac E. Kim, Philip K. Tonui, Peter M. Itsura, Ronald Tonui, Ann M. Moormann, Patrick J. Loehrer, Darron R. Brown, Omenge E. Orang’o, Susan Cu-Uvin, Aaron C. Ermel, Rachel A. Katzenellenbogen, Jeffrey A. Bailey   +19 more
doaj   +1 more source

Influences on uptake of cancer screening in mental health service users: a qualitative study. [PDF]

, 2016
BACKGROUND: Cancers are a leading cause of death worldwide. People with mental illness are 30 % more likely to die from cancer than the general population.
Sarah Clement (3513080), Clement, Sarah, Ohlsen, Ruth, Ruth Ohlsen, Elizabeth A. Barley, Caroline Burgess (3513071), Jackie Sturt, Burgess, C., Paul Walters (349725), Sturt, Jackie; id_orcid, Paul Walters, Clifton, A., Burgess, Caroline, Elizabeth Barley (3513077), Sturt, Jackie, Walters, Paul, Ruth Ohlsen (3513074), Sarah Clement, Sturt, J., Pras Ramluggun (3513083), Jackie Sturt (2885966), Ohlsen, R., Pras Ramluggun, Barley, Elizabeth A., Barley, Elizabeth, Clement, S., Clifton, Abigail, Ramluggun, Pras, Abigail Clifton, Ramluggun, P., Caroline Burgess, Abigail Clifton (3513086), Barley, E.A.   +32 more
core   +1 more source

The Development of Rheumatoid Arthritis–Specific Ambulatory Care–Sensitive Conditions: Results of a Consensus Process

Arthritis Care &Research, EarlyView.
Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin, Candace H. Feldman, Claire E. H. Barber, Gabriel Fabreau, Jake Jennings, Scott Patten, Cheryl Barnabe, Inflammatory Arthritis‐Specific ACSC Consensus Process Working Group   +7 more
wiley   +1 more source

The impact of supplementary narrative-based information on colorectal cancer screening beliefs and intention [PDF]

, 2015
Background: The potential benefits of colorectal cancer screening are limited by low uptake. This study tested whether providing narrative accounts of the colorectal cancer (CRC) screening experience positively affected beliefs about CRC screening and ...
McGregor, Lesley M, von Wagner, Christian, Raine, Rosalind, Wing Chee Yuen, von Wagner, C, Raine, R, Christian von Wagner, Robb, Kathryn A, Vart, Gemma, McGregor, LM, Kathryn A Robb, Robb, KA, Robb, Kathryn A., Jane Wardle, Wardle, Jane, Lesley M McGregor, McGregor, Lesley M., Rosalind Raine, Yuen, WC, Yuen, Wing Chee, Gemma Vart, Wardle, J, Vart, G   +22 more
core   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source