Results 61 to 70 of about 513,529 (353)

Human papillomavirus-based cervical screening and long-term cervical cancer risk: a randomised health-care policy trial in Sweden

The Lancet Public Health
Summary: Background: Human papillomavirus (HPV)-based cervical screening is a globally recommended public health policy. Randomised clinical trials find superior performance of primary HPV-based screening compared with cytology for preventing cervical ...
Jiangrong Wang, PhD, K Miriam Elfström, PhD, Joakim Dillner, ProfMD   +2 more
doaj   +1 more source

Is one dose of human papillomavirus vaccine as effective as three?: A national cohort analysis

Papillomavirus Research, 2019
Aim: Prophylactic human papillomavirus (HPV) vaccines are highly effective at preventing pre–cancerous cervical lesions when given in a three–dose schedule. Some post–hoc trial data suggest that one dose prevents HPV infection.
Julia ML. Brotherton, Alison Budd, Christopher Rompotis, Natasha Bartlett, Michael J. Malloy, Rachael L. Andersen, Kim AR. Coulter, Peter W. Couvee, Nerida Steel, Gail H. Ward, Marion Saville   +10 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cervical cancer screening utilization and associated factors among women of 30–65 years in Girar Jarsoo district North shoa, Ethiopia, 2021

Clinical Epidemiology and Global Health, 2022
Background: Cervical cancer screening is the method of early detection of cervical cancer before occurrence to decrease mortality and morbidity of the women.
Adugna Alemu Desta, Zerfu Mulaw Endale, Mastewal Belayneh Aklil   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

HPV self-sampling implementation strategies to engage under screened communities in cervical cancer screening: a scoping review to inform screening programs

Frontiers in Public Health
IntroductionHuman papillomavirus (HPV) testing as a method of cervical cancer screening can be performed by healthcare providers or by patients through self-sampling directly in the community, removing several barriers experienced by under screened ...
Madison M. Fullerton, Madison M. Fullerton, Caitlin Ford, Chelsea D’Silva, Bonnie Chiang, Se-Inyenede Onobrakpor, Holly Dievert, Huiming Yang, Jason Cabaj, Jason Cabaj, Noah Ivers, Noah Ivers, Sandra Davidson, Jia Hu, Jia Hu, Jia Hu   +15 more
doaj   +1 more source

The artificial intelligence‐assisted cytology diagnostic system in large‐scale cervical cancer screening: A population‐based cohort study of 0.7 million women

Cancer Medicine, 2020
Adequate cytology is limited by insufficient cytologists in a large‐scale cervical cancer screening. We aimed to develop an artificial intelligence (AI)‐assisted cytology system in cervical cancer screening program.
H. Bao, Xiaorong Sun, Yi Zhang, Baochuan Pang, Hua Li, Liang Zhou, Fengpin Wu, Dehua Cao, Jian Wang, B. Turic, Linhong Wang   +10 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Knowledge, attitudes, and barriers to screening for cervical cancer among women in India: a review [PDF]

World Cancer Research Journal, 2020
Early detection and treatment via screening can prevent up to 80% of cervical cancers in developed countries, where efficient screening programs are in place.
K. Vora, L. McQuatters, S. Saiyed, P. Gupta   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source