Results 71 to 80 of about 525,481 (282)

Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance We studied deep brain stimulation effects in two types of dystonia and conclude that different specific connections between the pallidum and thalamus are responsible for optimal treatment effects.
A. Horn, M. Reich, S. Ewert, Ningfei Li, B. Al-Fatly, F. Lange, J. Roothans, Simón Oxenford, I. Horn, S. Paschen, J. Runge, F. Wodarg, K. Witt, R. Nickl, M. Wittstock, G. Schneider, P. Mahlknecht, W. Poewe, W. Eisner, A. Helmers, C. Matthies, J. Krauss, G. Deuschl, J. Volkmann, A. Kühn   +24 more
semanticscholar   +1 more source

Cervico-shoulder dystonia following lateral medullary infarction: a case report and review of the literature

Journal of Medical Case Reports, 2018
Background Secondary cervical dystonia is induced by organic brain lesions involving the basal ganglia, thalamus, cerebellum, and brain stem. It is extremely rare to see cervical dystonia induced by a medullary lesion.
Takashi Ogawa, Yuri Shojima, Takuma Kuroki, Hiroto Eguchi, Nobutaka Hattori, Hideto Miwa   +5 more
doaj   +1 more source

Cervical dystonia and quality of life

Acta Neurologica Belgica, 2016
Cervical dystonia is focal dystonia characterized by involuntary movement of the neck muscle, which leads to abnormal head posture. It can be accompanied with pain and tremor. In this study, we evaluated the presence of depression and anxiety in patients with cervical dystonia and the influence of dystonia symptoms on the quality of life.
Tomislav Pucic, Ivana Petkovic, Bojan Resan, Bojan Resan, Stjepan Jurić, Svetlana Tomić, Tatjana Rotim   +6 more
openaire   +4 more sources

Detecting the Difficult: An Intronic NPC1 Variant Hiding in Plain Sight

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT An illustration of the importance of manual data review for identifying rare intronic variants adjacent to homopolymers is presented here. A 14‐year‐old male with Niemann‐Pick Type C disease confirmed biochemically was only found to have a heterozygous pathogenic variant by molecular analysis. A manual review of the Next Generation Sequencing (
Caroline Gully Brown, Matthew Bower, Matthew Schomaker, Jessica Goldstein, Jeanine Jarnes, Chester B. Whitley, Nishitha R. Pillai   +6 more
wiley   +1 more source

Sensory Alterations in Patients with Isolated Idiopathic Dystonia: An Exploratory Quantitative Sensory Testing Analysis

Frontiers in Neurology, 2017
Abnormalities in the somatosensory system are increasingly being recognized in patients with dystonia. The aim of this study was to investigate whether sensory abnormalities are confined to the dystonic body segments or whether there is a wider ...
Lejla Paracka, Lejla Paracka, Florian Wegner, Florian Wegner, Christian Blahak, Mahmoud Abdallat, Assel Saryyeva, Dirk Dressler, Matthias Karst, Joachim K. Krauss, Joachim K. Krauss   +10 more
doaj   +1 more source

Long-term follow-up of DYT1 dystonia patients treated by deep brain stimulation: an open-label study [PDF]

Mov Disord. 2010 Feb 15;25(3):289-99
Long-term efficacy of internal globus pallidus (GPi) deep-brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty-six patients of this open-label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology ...
arxiv   +1 more source

Unmet Needs in the Management of Cervical Dystonia [PDF]

Frontiers in Neurology, 2016
Cervical dystonia (CD) is a movement disorder which affects daily living of many patients. In clinical practice, several unmet treatment needs remain open. This article focuses on the four main aspects of treatment. We describe existing and emerging treatment approaches for CD, including botulinum toxin injections, surgical therapy, management of non ...
Maria Fiorella Contarino, Maria Fiorella Contarino, Marenka Smit, Joost Van Den Dool, Joost Van Den Dool, Joost Van Den Dool, Jens Volkmann, Marina Tijssen   +7 more
openaire   +7 more sources

Postural control during quiet standing following cervical muscular fatigue: effects of changes in sensory inputs [PDF]

Neuroscience Letters 378, 3 (2005) 135-9, 2008
The purpose of the present experiment was to investigate the effects of cervical muscular fatigue on postural control during quiet standing under different conditions of reliability and/or availability of somatosensory inputs from the plantar soles and the ankles and visual information.
arxiv   +1 more source

Objective Analysis of Neck Muscle Boundaries for Cervical Dystonia Using Ultrasound Imaging and Deep Learning

IEEE journal of biomedical and health informatics, 2020
Objective: To provide objective visualization and pattern analysis of neck muscle boundaries to inform and monitor treatment of cervical dystonia. Methods: We recorded transverse cervical ultrasound (US) images and whole-body motion analysis of sixty-one
Ian David Loram, Abdul Siddique, María B. Sánchez, P. Harding, M. Silverdale, C. Kobylecki, Ryan Cunningham   +6 more
semanticscholar   +1 more source

Investigating DYT1 in a Taiwanese dystonia cohort

Journal of the Formosan Medical Association, 2022
Background/purpose: A heterozygous three-nucleotide (GAG) in-frame deletion in the TOR1A gene causes the rare disease, dystonia (DYT1), which typically presents as focal limb dystonia during adolescence, then spreads to other limbs.
Meng-Chen Wu, Yung-Yee Chang, Ying-Fa Chen, Min-Yu Lan, Pei-Lung Chen, Chun-Hwei Tai, Chin-Hsien Lin   +6 more
doaj