Results 41 to 50 of about 11,030 (248)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Meta-analysis of the predictive value of ultrasonic measurement of cervical internal orifice width and cervical length for premature delivery

Journal of the Pakistan Medical Association
Objective: To systematically assess the predictive value of ultrasonic measurement of cervical internal orifice width and cervical length for premature delivery.
Pei Ma, Xiaoliu Shao, Ling Liu, Xiang Li, Haiyan Zhang, Lisi Zhang, Yu Liang, Na Li   +7 more
doaj   +1 more source

Study protocol to quantify the genetic architecture of sonographic cervical length and its relationship to spontaneous preterm birth

BMJ Open, 2022
Introduction A short cervix (cervical length <25 mm) in the midtrimester (18–24 weeks) of pregnancy is a powerful predictor of spontaneous preterm delivery.
Shawn J Latendresse, Jerome F Strauss, Timothy P York, Roberto Romero, Hope M Wolf, Sonia S Hassan, Bradley T Webb, Adi L Tarca, Nardhy Gomez-Lopez, Chaur-Dong Hsu   +9 more
doaj   +1 more source

Indicators for Cervical Length in Twin Pregnancies

American Journal of Perinatology, 2015
Cervical length (CL) is associated with the risk of preterm birth (PTB) in multiple pregnancies. However, the position of CL within the pathophysiological pathway of PTB is unclear, and it is unknown which factors are predictive for CL. This study aims to investigate whether in twin pregnancies baseline maternal and obstetrical characteristics are ...
Hermans, F.J.R., Schuit, E., Liem, S.M.S., Lim, A.C., Duvekot, J., Scheepers, L.C.J., Woiski, M.M., Franssen, M.M., Oudijk, M.A., Bloemenkamp, K.W.M., Bijvanck, B.N., Bekedam, D.J., Opmeer, B.C., Mol, B.W.J.   +13 more
openaire   +7 more sources

Ultrasound measurement of cervical length in the second trimester of pregnancy for prediction of preterm delivery [PDF]

, 2019
Background: Short cervical length is a risk factor for preterm delivery (PTD) and screening of cervical length using transvaginal ultrasound in the second trimester is a proposed method to find women at risk Aims: To examine the potential value of ...
Kuusela, Pihla
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Detecção molecular do DNA e RNAm do HPV e sua aplicabilidade na triagem do câncer cervical [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011O câncer de colo uterino representa o segundo tipo de câncer mais comum entre as mulheres.
Martins, Toni Ricardo
core  

Commonly used percentiles for cervical length (mm).

, 2023
Commonly used percentiles for cervical length (mm).
Chang-Ching Yeh (606190), Ksenia Olisova (17102515), Tung-Yao Chang (4691635), Chih-Hsuan Sao (17102518), Eric C. Lussier (4691632), Peng-Hui Wang (329082), Chan-Yu Sung (17102521)   +6 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source