Results 21 to 30 of about 79,200 (218)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

SARCOMATOID DIFFUSE LARGE B-CELL LYMPHOMA: A RARE MORPHOLOGICAL VARIANT WITH MULTI-VISCERAL INVOLVEMENT

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin's lymphoma (NHL), accounting for 50% of all NHL cases seen at HC-FMUSP. Up to 40-50% of DLBCL cases have extranodal involvement. However, female genital tract
PPF Machado, GGM Lima, LF Castelo, V Rocha, LAPC Lage, J Pereira   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Primary analysis of malignant neoplasm trends and demographics in hospitalized patients in Kashi prefecture from 2016 to 2023

BMC Cancer
Objective To analyze the ranking, composition, trend changes, and distribution by gender and ethnicity of malignant neoplasms in hospitalized patients in the Kashi prefecture from 2016 to 2023. This analysis aims to provide a reference for the prevention
Nueraili Kade, Wusiman Yakufu, Cheng Zhang, Lin Wang, Qingqing Qian, Xiaochuan Liu, Long Jia, Chunfeng Wu, Weihua Chen, Tianxiang Chen   +9 more
doaj   +1 more source

Biatrial Cardiac Metastases in a Patient with Uterine Cervix Malignant Melanoma

Case Reports in Cardiology, 2015
Primary malignant melanomas of uterine cervix are quite rarely seen neoplasms, and long-life prognosis of patients with this disease is poor. Immunohistochemical methods and exclusion of other primary melanoma sites are used to confirm the diagnosis.
Caglayan Geredeli, Melih Cem Boruban, Necdet Poyraz, Mehmet Artac, Alpay Aribas, Lokman Koral   +5 more
doaj   +1 more source

Female Genital Tract Involvement in Acute Lymphoblastic Leukemia: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Female Genital Tract (FGT) involvement with hematologic neoplasms is uncommon and the hematologic malignancies which involve the female genital organs are usually non-Hodgkin’s lymphoma.
Vikram Narang, Amit Dhiman, Bhavna Garg, Neena Sood   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Colloid Carcinoma of the Uterine Cervix and Its Immunohistochemical Analysis: A Case Report [PDF]

Journal of Pathology and Translational Medicine, 2018
Colloid carcinoma, which is a very rare tumor of the uterine cervix, is composed of an excessive amount of mucus and a relative paucity of tumoral glandular cells within them.
Nermin Koc, Sevcan Arzu Arinkan, Nurver Ozel Ozbay, Selcuk Selcuk   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Some correlations between eight types of malignant neoplasms: A hint from cancer dynamics of 31 European countries in 20 years [PDF]

Network Biology, 2017
In present study, the data of standardised death rates of malignant neoplasms per 100000 inhabitants in 31 European countries during 1994-2013 were used to analyze linear correlations between eight types of cancers in terms of induced death rates.
WenJun Zhang
doaj