Results 51 to 60 of about 77,111 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Colloid Carcinoma of the Uterine Cervix and Its Immunohistochemical Analysis: A Case Report [PDF]

Journal of Pathology and Translational Medicine, 2018
Colloid carcinoma, which is a very rare tumor of the uterine cervix, is composed of an excessive amount of mucus and a relative paucity of tumoral glandular cells within them.
Nermin Koc, Sevcan Arzu Arinkan, Nurver Ozel Ozbay, Selcuk Selcuk   +3 more
doaj   +1 more source

AGE-RELATED CLINICAL, ANATOMICAL AND MORPHOLOGICAL FEATURES OF MALIGNANT TUMORS OF THE CERVIX

, 2021
The aim of the study is to study the clinical, anatomical and morphological features of malignant neoplasms of the cervix uteri in fertile and elderly women.
Makhmudova G.F.
core   +1 more source

Primary non-Hodgkin's lymphoma of the uterine cervix: A case report [PDF]

Archive of Oncology, 2004
Primary uterine cervical non-Hodgkin's lymphomas (NHL) are rare. Limited experience dictates careful pretherapy evaluation and multidisciplinary approach in treatment planning. A 53-year-old woman presented with postmenopausal bleeding and PAP smear IIIb.
Živaljević Milica, Vujkov Tamara, Jovanović Darjana V., Mandić Aljoša, Mihajlović Olgica, Prvulović Mladen, Stojiljković Bratislav T.   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Rare Incidental Case of Lipoleiomyoma Cervix

, 2015
Lipoleiomyomas are uncommon benign mesenchymal neoplasms of uterus and are regarded as a rare variant of uterine leiomyomas. They constitute less than 0.2% of benign uterine tumors.
Sonam Sharma, Charanjeet Ahluwalia, A.K. Mandal   +2 more
core   +1 more source

Perfil de mulheres de 40 a 49 anos cadastradas em um núcleo de saúde da família, quanto à realização do exame preventivo de Papanicolaou Perfil de mujeres de 40 a 49 años registradas en un núcleo de salud de la familia en cuanto a la realización del examen preventivo de Papanicolaou Pap smear realization profile of women between 40 and 49 years registered at a family health center

Revista Latino-Americana de Enfermagem, 2006
Trata-se de pesquisa de abordagem descritiva, exploratória, cujo objetivo é traçar o perfil de mulheres na faixa etária de 40 a 49 anos, em um Núcleo de Saúde da Família do Município de Ribeirão Preto, segundo as variáveis: cadastro no serviço, posse de ...
Aline da Silveira Ramos, Pedro Fredemir Palha, Moacyr Lobo da Costa Júnior, Sônia Camila Sant'Anna, Nariman de Felicio Bortucan Lenza   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation

, 2015
Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix.
Andrade, LALD, Cunha-Mercante, AM, Ribeiro-Silva, A, Novello-Vilar, A   +3 more
core   +1 more source